Treated and treatment-naive alcoholics come from different populations.
- Authors
- Fein, George; Landman, Bennett
- Year
- 2005
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 16440475
- PMCID
- PMC1868689
In most research on alcoholism, convenience samples of individuals who have been in some type of treatment are used. Berkson's fallacy results when the associations found in studies of select samples are incorrectly presumed to apply to all alcoholics (i.e., including untreated alcoholics in the general population). In the current study, we examined whether treated and untreated alcoholics have similar early alcohol use histories by comparing abstinent alcoholics (treated and sober at least 6 months) with treatment-naive alcoholics (active drinkers). We studied 14 pairs of women and 25 pairs of men matched on the age at which they first met criteria for heavy alcohol use (women, 80 drinks per month; men, 100 drinks per month). The timeline follow-back interview method was used to gather retrospective alcohol use information. Alcohol dose and duration of use were subsequently computed for two intervals: (1) time between the person's first drink and date at which the person met criteria for heavy drinking and (2) period between when criteria for heavy drinking were met and current age of the treatment-naive person from each pair. During the period before the matching "heavy drinking" criteria were met, alcohol dose did not differ between groups. In the period after criteria for heavy alcohol use were met, in comparison with treatment-naive alcoholics, the treated alcoholics had higher average and peak alcohol doses. We rejected the hypothesis that the treatment-naive alcoholics and the treated alcoholics have similar alcohol use trajectories over time, with the treatment-naive sample simply being observed earlier in its alcohol use histories. Instead, we concluded that the two groups come from different populations with regard to alcohol use. In fact, the treated alcoholics had alcohol doses more than 50% higher than those of treatment-naive alcoholics in the years just after they began drinking heavily. This finding supports the suggestion that results from studies of alcoholics in treatment or after treatment (i.e., most studies of alcoholics) cannot be generalized to untreated individuals (who make up the majority of alcoholics).
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A Fresh Look at the Allostasis Theory of Addiction. | Heilig M | β | 2025 | β |
| Associations between alcohol use disorder polygenic score andΒ remission in participants from high-risk families and the Indiana Biobank. | Lai D et al. | β | 2024 | β |
| Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia. | Sullivan EV et al. | β | 2023 | β |
| Childhood Trauma and Dissociation Correlates in Alcohol Use Disorder: A Cross-Sectional Study in a Sample of 587 French Subjects Hospitalized in a Rehabilitation Center. | Baudin G et al. | β | 2022 | β |
| Translational Structural and Functional Signatures of Chronic Alcohol Effects in Mice. | Degiorgis L et al. | β | 2022 | β |
| The future of translational research on alcohol use disorder. | Ray LA et al. | β | 2021 | β |
| Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity. | Le Berre AP et al. | β | 2020 | β |
| Family structure and alcohol use disorder: a register-based cohort study among offspring with and without parental alcohol use disorder. | Holst C et al. | β | 2020 | β |
| Comment on the Paper by Berglund et al. (2019) "Outcome in Relation to Drinking Goals in Alcohol-Dependent Individuals: A Follow-Up Study 2.5 and 5Β Years After Treatment Entry". | Andreasson S et al. | β | 2019 | β |
| Differences between treatment-seeking and non-treatment-seeking participants in medication studies for alcoholism: do they matter? | Ray LA et al. | β | 2017 | β |
| Psychiatric Comorbidity in Alcohol Dependence. | Fein G | β | 2015 | β |
| Chronic alcohol consumption and its effect on nodes of frontocerebellar and limbic circuitry: comparison of effects in France and the United States. | Le Berre AP et al. | β | 2014 | β |
| Social contexts of remission from DSM-5 alcohol use disorder in a high-risk sample. | McCutcheon VV et al. | β | 2014 | β |
| Absence of P300 reduction in South African treatment-naΓ―ve adolescents with alcohol dependence. | Cuzen NL et al. | β | 2013 | β |
| Brain structure in adolescents and young adults with alcohol problems: systematic review of imaging studies. | Welch KA et al. | β | 2013 | β |
| Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism. | Schwandt ML et al. | β | 2013 | β |
| Differential brain response to alcohol cue distractors across stages of alcohol dependence. | Fryer SL et al. | β | 2013 | β |
| Effects of smoking on Dβ/Dβ striatal receptor availability in alcoholics and social drinkers. | Albrecht DS et al. | β | 2013 | β |
| Ethnicity and gender comparisons of health consequences in adults with alcohol dependence. | Chartier KG et al. | β | 2013 | β |
| Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter. | Ende G et al. | β | 2013 | β |
| Neurometabolite concentration and clinical features of chronic alcohol use: a proton magnetic resonance spectroscopy study. | Yeo RA et al. | β | 2013 | β |
| White matter volume in alcohol use disorders: a meta-analysis. | Monnig MA et al. | β | 2013 | β |
| A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls. | van Holst RJ et al. | β | 2012 | β |
| Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. | Breese GR et al. | β | 2011 | β |
| Event-related potentials during visual target detection in treatment-naΓ―ve active alcoholics. | Fein G et al. | β | 2011 | β |
| Pharmacogenetic approaches to the treatment of alcohol addiction. | Heilig M et al. | β | 2011 | β |
| Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome. | Pitel AL et al. | β | 2011 | β |
| Ethical considerations for administering alcohol or alcohol cues to treatment-seeking alcoholics in a research setting: can the benefits to society outweigh the risks to the individual? A commentary in the context of the National Advisory Council on Alcohol Abuse and Alcoholism -- Recommended Council Guidelines on Ethyl Alcohol Administration in Human Experimentation (2005). | Enoch MA et al. | β | 2009 | β |
| Magnetic resonance imaging of the living brain: evidence for brain degeneration among alcoholics and recovery with abstinence. | Rosenbloom MJ et al. | β | 2008 | β |
| Sex differences in the heritability of alcohol problems. | Hardie TL et al. | β | 2008 | β |
| Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation. | Durazzo TC et al. | β | 2007 | β |
| Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part I: adult brain growth. | Sullivan EV et al. | β | 2006 | β |
| Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part II: effects of voluntary chronic alcohol consumption. | Pfefferbaum A et al. | β | 2006 | β |
| Health risks of chronic moderate and heavy alcohol consumption: how much is too much? | Meyerhoff DJ et al. | β | 2005 | β |