P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development.
paper
Cited
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- Authors
- Bauer, L O; Hesselbrock, V M
- Year
- 1999
- Journal
- Biological psychiatry
- PMID
- 10418702
- DOI
- 10.1016/s0006-3223(98)00335-7
BACKGROUND: The purpose of this study was to evaluate the effects of conduct disorder problems, family history, gender, and age on P300 electroencephalographic potentials in teenagers. METHODS: The 257 subjects, aged 15 to 20 years, were assigned to one of twelve groups defined by the crossing of three between-subjects factors: 1) gender; 2) ranking below vs above the median number of conduct disorder problems for their gender; and 3) no family history of alcohol or drug dependence vs familial alcohol dependence vs familial heroin or cocaine dependence. RESULTS: P300 amplitude was smaller among subjects reporting a greater number of conduct problems prior to age 15 vs those reporting fewer problems of this type. No family history effects were detected. Another set of analyses examined the effects of age on conduct problem-related decrements in P300. Smaller P300 amplitudes within the posterior scalp region were associated with a greater number of conduct problems among subjects younger than 16.5 years. Among subjects greater than this median age, the effects of these behaviors were only apparent over the frontal scalp. CONCLUSIONS: It is concluded that P300 decrements previously attributed to familial alcohol/substance dependence might be the result of a coincident increase in the prevalence of conduct disorder problems. The analysis of age interactions suggests that P300 amplitude decrements observed at posterior scalp sites among subjects with more conduct problems disappear at approximately 16 to 17 years of age. After that age, decrements in frontal brain function may begin to emerge in the subset of conduct problem subjects who are at risk for developing adult antisocial personality disorder.
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|---|---|---|---|---|
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| Variants of the P3 event-related potential operate as indicators of distinct mechanisms contributing to problematic alcohol use. | Joyner KJ et al. | — | 2024 | → |
| Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder. | Petrie J et al. | — | 2023 | → |
| Examining impulsivity and risky decision making among school youth in balloon analogue risk task. | Gong Y et al. | — | 2022 | → |
| Inter-trial variability in postural control and brain activation: Effects of previous opiate abuse. | Bauer LO | — | 2022 | → |
| Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology . | Perkins ER et al. | — | 2020 | → |
| P300 development from infancy to adolescence. | Riggins T et al. | — | 2020 | → |
| Psychosocial intervention in at-risk adolescents: using event-related potentials to assess changes in decision making and feedback processing. | Pincham HL et al. | — | 2019 | → |
| Classification and treatment of antisocial individuals: From behavior to biocognition. | Brazil IA et al. | — | 2018 | → |
| Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. | Crews FT et al. | — | 2016 | → |
| Brain potentials predict substance abuse treatment completion in a prison sample. | Fink BC et al. | — | 2016 | → |
| Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing. | Pandey AK et al. | — | 2016 | → |
| Psychosocial Intervention Is Associated with Altered Emotion Processing: An Event-Related Potential Study in At-Risk Adolescents. | Pincham HL et al. | — | 2016 | → |
| A general population twin study of conduct problems and the auditory P300 waveform. | Bertoletti E et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Protracted impairment of impulse control under an acute dose of alcohol: a time-course analysis. | Miller MA et al. | — | 2014 | → |
| The impact of cognitive control, incentives, and working memory load on the P3 responses of externalizing prisoners. | Baskin-Sommers AR et al. | — | 2014 | → |
| Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence. | Cuzen NL et al. | — | 2013 | → |
| Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. | Yoon HH et al. | — | 2013 | → |
| Evidence for a Heritable Brain Basis to Deviance-Promoting Deficits in Self-Control. | Yancey JR et al. | — | 2013 | → |
| Multifactorial determinants of target and novelty-evoked P300 amplitudes in children of addicted parents. | Euser AS et al. | — | 2013 | → |
| The association between p3 amplitude at age 11 and criminal offending at age 23. | Gao Y et al. | — | 2013 | → |
| Differentiating psychopathy from general antisociality using the P3 as a psychophysiological correlate of attentional allocation. | Brazil IA et al. | — | 2012 | → |
| Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism. | Wetherill RR et al. | — | 2012 | → |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | — | 2012 | → |
| Reconceptualizing antisocial deviance in neurobehavioral terms. | Patrick CJ et al. | — | 2012 | → |
| Revisiting the concepts of risk and protective factors for understanding the etiology and development of substance use and substance use disorders: implications for prevention. | Sloboda Z et al. | — | 2012 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| Visual complexity attenuates emotional processing in psychopathy: implications for fear-potentiated startle deficits. | Sadeh N et al. | — | 2012 | → |
| Event-related potentials in impulsively aggressive juveniles: a retrospective chart-review study. | Fisher W et al. | — | 2011 | → |
| Imaging brain response to reward in addictive disorders. | Hommer DW et al. | — | 2011 | → |
| N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence. | Ehlers CL et al. | — | 2011 | → |
| Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? | Ehlers CL et al. | — | 2010 | → |
| Children of addicted women. | Lester BM et al. | — | 2010 | → |
| Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats. | Criado JR et al. | — | 2010 | → |
| Specificity of P3 event-related potential reactivity to alcohol cues in individuals low in alcohol sensitivity. | Bartholow BD et al. | — | 2010 | → |
| Auditory P300 event-related potentials and neurocognitive functions in opioid dependent men and their brothers. | Singh SM et al. | — | 2009 | → |
| Auditory P300 study in remittent bipolar child and adolescent population. | Sur S et al. | — | 2009 | → |
| Contextualizing the neurobiology of conduct disorder in an emotion dysregulation framework. | Cappadocia MC et al. | — | 2009 | → |
| P3 event-related potential impairments in antisocial and psychopathic individuals: a meta-analysis. | Gao Y et al. | — | 2009 | → |
| Visual P3 amplitude and self-reported psychopathic personality traits: frontal reduction is associated with self-centered impulsivity. | Carlson SR et al. | — | 2009 | → |
| Adolescents at risk for substance use disorders: role of psychological dysregulation, endophenotypes, and environmental influences. | Thatcher DL et al. | — | 2008 | → |
| A family history of psychopathology modifies the decrement in cognitive control among patients with HIV/AIDS. | Bauer LO | — | 2008 | → |
| Attentional deficits in cocaine-dependent patients: converging behavioral and electrophysiological evidence. | Gooding DC et al. | — | 2008 | → |
| EEG biofeedback as a treatment for substance use disorders: review, rating of efficacy, and recommendations for further research. | Sokhadze TM et al. | — | 2008 | → |
| Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. | Spadoni AD et al. | — | 2008 | → |
| Event-Related Potential Study of Executive Dysfunctions in a Speeded Reaction Task in Cocaine Addiction. | Sokhadze E et al. | — | 2008 | → |
| Impulsivity, intelligence and P300 wave: an empirical study. | Russo PM et al. | — | 2008 | → |
| Neurobiological processes in adolescent addictive disorders. | Schepis TS et al. | — | 2008 | → |
| P3 components of the event-related potential and marijuana dependence in Southwest California Indians. | Ehlers CL et al. | — | 2008 | → |
| Peer environment mediates parental history and individual risk in the etiology of cannabis use disorder in boys: a 10-year prospective study. | Feske U et al. | — | 2008 | → |
| Predicting treatment outcome in stimulant dependence. | Reske M et al. | — | 2008 | → |
| Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. | Medina KL et al. | — | 2008 | → |
| The effects of childhood disruptive disorder comorbidity on P3 event-related brain potentials in preadolescents with ADHD. | Yoon HH et al. | — | 2008 | → |
| The role of selected factors in the development and consequences of alcohol dependence. | Gilbertson R et al. | — | 2008 | → |
| Cognitive deficits in children of alcoholics: At risk before the first sip! | Silva MC et al. | — | 2007 | → |
| Electrophysiological responses to affective stimuli in Mexican Americans: Relationship to alcohol dependence and personality traits. | Criado JR et al. | — | 2007 | → |
| Lower P300 amplitude in eight-year-old offspring of alcoholic fathers with a delinquent history. | Viana-Wackermann PC et al. | — | 2007 | → |
| Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children. | Stieben J et al. | — | 2007 | → |
| P3 components and adolescent binge drinking in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Violent offending predicts P300 amplitude. | Bernat EM et al. | — | 2007 | → |
| Brain potentials implicate temporal lobe abnormalities in criminal psychopaths. | Kiehl KA et al. | — | 2006 | → |
| Children with oppositional-defiant disorder display deviant attentional processing independent of ADHD symptoms. | Baving L et al. | — | 2006 | → |
| Cocaine-dependence and cocaine-induced paranoia and mid-latency auditory evoked responses and sensory gating. | Boutros NN et al. | — | 2006 | → |
| Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2006 | → |
| Individual differences in childhood neurobehavior disinhibition predict decision to desist substance use during adolescence and substance use disorder in young adulthood: a prospective study. | Kirisci L et al. | — | 2006 | → |
| P300 amplitude as an indicator of externalizing in adolescent males. | Patrick CJ et al. | — | 2006 | → |
| Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task. | Kamarajan C et al. | — | 2005 | → |
| Association among parental substance use disorder, p300 amplitude, and neurobehavioral disinhibition in preteen boys at high risk for substance use disorder. | Habeych ME et al. | — | 2005 | → |
| Auditory P3 indexes personality traits and cognitive function in healthy men and women. | Gurrera RJ et al. | — | 2005 | → |
| Borderline personality disorder features in adolescent girls: P300 evidence of altered brain maturation. | Houston RJ et al. | — | 2005 | → |
| Detection of youth at high risk for substance use disorders: a longitudinal study. | Kirisci L et al. | — | 2005 | → |
| Direct and mediated associations between P300 amplitude in childhood and substance use disorders outcome in young adulthood. | Habeych ME et al. | — | 2005 | → |
| Influence of history of head trauma and epilepsy on delinquents in a juvenile classification home. | Miura H et al. | — | 2005 | → |
| P3 amplitude and time-on-task effects in distractible adolescents. | Määttä S et al. | — | 2005 | → |
| Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2005 | → |
| The human adolescent brain and alcohol use disorders. | Tapert SF et al. | — | 2005 | → |
| Towards an understanding of unique and shared pathways in the psychopathophysiology of ADHD. | Banaschewski T et al. | — | 2005 | → |
| Alcoholism risk, tobacco smoking, and P300 event-related potential. | Polich J et al. | — | 2004 | → |
| Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. | Houston RJ et al. | — | 2004 | → |
| Genetics, pharmacokinetics, and neurobiology of adolescent alcohol use. | — | — | 2004 | → |
| Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. | Bjork JM et al. | — | 2004 | → |
| Long-term abstinence syndrome in heroin addicts: indices of P300 alterations associated with a short memory task. | Papageorgiou CC et al. | — | 2004 | → |
| P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects. | Moeller FG et al. | — | 2004 | → |
| P300 evidence of cognitive inflexibility in female adolescents at risk for recurrent depression. | Houston RJ et al. | — | 2004 | → |
| The clinical course of alcoholism in 243 Mission Indians. | Ehlers CL et al. | — | 2004 | → |
| Alcoholism risk and the P300 event-related brain potential: modality, task, and gender effects. | Reese C et al. | — | 2003 | → |
| Brain maturation and subtypes of conduct disorder: interactive effects on p300 amplitude and topography in male adolescents. | Bauer LO et al. | — | 2003 | → |
| Depression and familial risk for substance dependence: a P300 study of young women. | Houston RJ et al. | — | 2003 | → |
| Moral cognition and its neural constituents. | Casebeer WD | — | 2003 | → |
| P300 (latency) event-related potential: an accurate predictor of memory impairment. | Braverman ER et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |
| Altered emotion-modulated startle in young adults with a family history of alcoholism. | Miranda R et al. | — | 2002 | → |
| Children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder: an EEG analysis. | Clarke AR et al. | — | 2002 | → |
| Long latency event-related potentials in mice: effects of stimulus characteristics and strain. | Ehlers CL et al. | — | 2002 | → |
| Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis. | Hill SY et al. | — | 2002 | → |
| Neurophysiological profiles of replicate line 2 high-alcohol-drinking (HAD-2) and low-alcohol-drinking (LAD-2) rats. | Katner SN et al. | — | 2002 | → |
| P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders. | Carlson SR et al. | — | 2002 | → |
| A comparison of correlates of DSM-IV alcohol abuse or dependence among more than 400 sons of alcoholics and controls. | Schuckit MA et al. | — | 2001 | → |
| Alcohol use disorders and anxiety disorders: relation to the P300 event-related potential. | Enoch MA et al. | — | 2001 | → |
| Antisocial personality disorder and cocaine dependence: their effects on behavioral and electroencephalographic measures of time estimation. | Bauer LO | — | 2001 | → |
| CNS recovery from cocaine, cocaine and alcohol, or opioid dependence: a P300 study. | Bauer LO | — | 2001 | → |
| CSD/BEM localization of P300 sources in adolescents "at-risk": evidence of frontal cortex dysfunction in conduct disorder. | Bauer LO et al. | — | 2001 | → |
| Effects of age and parental history of alcoholism on EEG findings in mission Indian children and adolescents. | Ehlers CL et al. | — | 2001 | → |
| Frontal P300 decrement and executive dysfunction in adolescents with conduct problems. | Kim MS et al. | — | 2001 | → |
| P300, disinhibited personality, and early-onset alcohol problems. | Justus AN et al. | — | 2001 | → |
| P300 event-related potential amplitude as an endophenotype of alcoholism--evidence from the collaborative study on the genetics of alcoholism. | Hesselbrock V et al. | — | 2001 | → |
| P3 event-related potential, dopamine D2 receptor A1 allele, and sensation-seeking in adult children of alcoholics. | Ratsma JE et al. | — | 2001 | → |
| The P3 auditory event-related brain potential indexes major personality traits. | Gurrera RJ et al. | — | 2001 | → |
| The relationship of perceived social support to substance use in offspring of alcoholics. | Averna S et al. | — | 2001 | → |
| Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems. | Ehlers CL et al. | — | 2001 | → |
| Frontal P300 decrements, alcohol dependence, and antisocial personality disorder. | Costa L et al. | — | 2000 | → |
| Genetics of the risk for alcoholism. | Schuckit MA | — | 2000 | → |
| Neurophysiological findings and drinking levels in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. | Slawecki CJ et al. | — | 2000 | → |
| P300, a state and a trait marker in schizophrenia. | Blackwood D | — | 2000 | → |
| Relationship between attitudinal hostility and P300 latencies. | Bond AJ et al. | — | 2000 | → |
| Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. | Blum K et al. | — | 2000 | → |
| What is inherited in the predisposition to alcoholism: new model or more muddle? | Tarter RE | — | 2000 | → |