Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism.

paper Cited Public

Authors: Wetherill, Reagan R; Bava, Sunita; Thompson, Wesley K; Boucquey, Veronique; Pulido, Carmen; Yang, Tony T; Tapert, Susan F
Year: 2012
Journal: Brain research
PMID: 22138427
DOI: 10.1016/j.brainres.2011.11.013
PMCID: PMC3246051

#	Section	Preview
0	1. Introduction	Alcohol use is common during adolescence, with typical onset of drinking between ages of 15 and 17…
1	1. Introduction	Chronic alcoholism has been associated with structural brain changes (Crews & Nixon, 2009;…
2	1. Introduction	Neurobiological markers of vulnerability that exist prior to alcohol initiation have been suggested…
3	1. Introduction	The current study expands on the existing literature by examining frontoparietal network functioning…
4	1. Introduction	In contrast, DTI can assess structural networks by quantifying the diffusion of water molecules in…
5	1. Introduction	We examined fcMRI and underlying white matter microstructure in specific frontoparietal areas…
6	2. Results — 2.1. Task Performance	FHP youth did not significantly differ from FHN youth on accuracy or reaction time on the visual…
7	2. Results — 2.2. Frontoparietal Connectivity	Frontoparietal connectivity in FHP and FHN youth was examined by using fcMRI maps (corrected for…
8	2. Results — 2.2. Frontoparietal Connectivity	.35, p < .001]. In contrast, the FHP youth exhibited positive correlations between the right PPC and…
9	2. Results — 2.2. Frontoparietal Connectivity	To evaluate structural connectivity differences between FHP and FHN youth, we compared DTI indices…
10	2. Results — 2.3. Frontoparietal Connectivity and Task Performance	Follow-up Pearson’s correlation analyses were performed to examine the relationship between the…
11	3. Discussion	The goal of this study was to examine the association between family history of alcohol use…
12	3. Discussion	in PPC to DLPFC) than their FHN counterparts. Follow-up correlation analyses revealed that…
13	3. Discussion	Contrary to our hypothesis, FHP youth did not show altered white matter architecture in tracts…
14	3. Discussion	Although we found significant connectivity differences between substance-naïve FHP and FHN youth…
15	3. Discussion	These data should be considered in light of possible limitations. Our relatively small sample size…
16	3. Discussion	The current study demonstrates that substance-naïve youth with a family history of alcohol use…
17	3. Discussion	cognitive training could affect frontoparietal connectivity by encouraging co-activation of neurons…
18	4. Methods — 4.1. Participants	Participants were 20 FHP (50% female) and 20 FHN (50% female) 12–14 year-old substance-naïve…
19	4. Methods — 4.1. Participants	Exclusionary criteria were: parental history of bipolar, psychotic, or antisocial personality…

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