Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders.
paper
Primary
Public
Unavailable
- Authors
- Porjesz, Bernice; Rangaswamy, Madhavi
- Year
- 2007
- Journal
- TheScientificWorldJournal
- PMID
- 17982586
- DOI
- 10.1100/tsw.2007.203
- PMCID
- PMC5901350
Biological endophenotypes are more proximal to gene function than psychiatric diagnosis, providing a powerful strategy in searching for genes in psychiatric disorders. These intermediate phenotypes identify both affected and unaffected members of an affected family, including offspring at risk, providing a more direct connection with underlying biological vulnerability. The Collaborative Study on the Genetics of Alcoholism (COGA) has employed heritable neurophysiological features (i.e., brain oscillations) as endophenotypes, making it possible to identify susceptibility genes that may be difficult to detect with diagnosis alone. We found significant linkage and association between brain oscillations and genes involved with inhibitory neural networks (e.g., GABRA2, CHRM2), including frontal networks that are deficient in individuals with alcohol dependence, impulsivity, and related disinhibitory disorders. We reported significant linkage and linkage disequilibrium for the beta frequency of the EEG and GABRA2, a GABAA receptor gene on chromosome 4, which we found is also associated with diagnosis of alcohol dependence and related disorders. More recently, we found significant linkage and association with GABRA2 and interhemispheric theta coherence. We also reported significant linkage and linkage disequilibrium between the theta and delta event-related oscillations underlying P3 to target stimuli and CHRM2, a cholinergic muscarinic receptor gene on chromosome 7, which we found is also associated with diagnosis of alcohol dependence and related disorders. Thus, the identification of genes important for the expression of the endophenotypes (brain oscillations) helps when identifying genes that increase the susceptibility for risk of alcohol dependence and related disorders. These findings underscore the utility of quantitative neurophysiological endophenotypes in the study of the genetics of complex disorders. We will present our recent genetic findings related to brain oscillations and Central Nervous System (CNS) disinhibition.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | Richard CD et al. | β | 2026 | β |
| Revisiting drunk driving risk among individuals with alcohol use disorder using unsupervised learning: From clinical characteristics and neuropsychological performance to EEG data. | Su YR et al. | β | 2026 | β |
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state | Richard C et al. | β | 2025 | β |
| Altered Low-beta Characteristics in Individuals With Alcohol Use Disorder: A Pilot Resting Electroencephalography Study. | Li B et al. | β | 2025 | β |
| Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth. | Elliott AS et al. | β | 2025 | β |
| Frontal Theta Event-Related Oscillations During a Continuous Performance Test: The Influence of Trauma Type and Fluid Intelligence Polygenic Score. | Saenz de Viteri S et al. | β | 2025 | β |
| Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms. | Neale ZE et al. | β | 2024 | β |
| GABAergic compounds for the treatment of alcohol use disorder. | Berro LF et al. | β | 2024 | β |
| Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder. | Petrie J et al. | β | 2023 | β |
| Targeting electroencephalography for alcohol dependence: AΒ narrative review. | Zhang H et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | β | 2023 | β |
| Alterations of theta power and synchrony during encoding in young adult binge drinkers: Subsequent memory effects associated with retrieval after 48 h and 6 months. | Huang S et al. | β | 2022 | β |
| Cortical GABA levels are reduced in young adult binge drinkers: Association with recent alcohol consumption and sex. | Marinkovic K et al. | β | 2022 | β |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | β | 2022 | β |
| Exploration of the Impact of Combining Risk Phenotypes on the Likelihood of Alcohol Problems in Young Adults. | Kampov-Polevoy A et al. | β | 2022 | β |
| Signal in the noise:Β Altered brain activation among adolescent alcohol users detected via the analysis of intra-individual variability<sup>1</sup>. | Bauer LO et al. | β | 2022 | β |
| The Interactive Effect of Genetic and Epigenetic Variations in <i>FKBP5</i> and <i>ApoE</i> Genes on Anxiety and Brain EEG Parameters. | Kuznetsova IL et al. | β | 2022 | β |
| The Personality Traits and P300 of Offspring of Parents With Alcohol Dependence Differ Depending on Current Risky Drinking: A Preliminary Case-Control Study. | Qiu Y et al. | β | 2022 | β |
| Abnormal organization of inhibitory control functional networks in future binge drinkers. | AntΓ³n-Toro LF et al. | β | 2021 | β |
| A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior. | Meyers JL et al. | β | 2021 | β |
| Alcohol unleashes homo economicus by inhibiting cooperation. | Zak PJ et al. | β | 2021 | β |
| Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol. | Sharma E et al. | β | 2020 | β |
| Neural Responses to Signals for Behavior Change: Greater Within-Person Variability is Associated With Risk Factors for Substance Dependence. | Bauer LO | β | 2020 | β |
| Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment? | Jurado-Barba R et al. | β | 2020 | β |
| Resting-state connectivity and network parameter analysis in alcohol-dependent males. A simultaneous EEG-MEG study. | Sion A et al. | β | 2020 | β |
| Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. | Meyers JL et al. | β | 2019 | β |
| CHRM2 Genotype Affects Inhibitory Control Mechanisms During Cognitive Flexibility. | Zink N et al. | β | 2019 | β |
| Altered oscillatory brain dynamics of emotional processing in young binge drinkers. | Huang S et al. | β | 2018 | β |
| P3 Component as a Potential Endophenotype for Control Inhibition in Offspring of Alcoholics. | DomΓnguez-Centeno I et al. | β | 2018 | β |
| Quantifying the dynamics of electroencephalographic (EEG) signals to distinguish alcoholic and non-alcoholic subjects using an MSE based K-d tree algorithm. | Hussain L et al. | β | 2018 | β |
| Heterogeneity of emotional and interpersonal difficulties in alcohol-dependence: A cluster analytic approach. | Maurage P et al. | β | 2017 | β |
| Quantitative EEG during normal aging: association with the Alzheimer's disease genetic risk variant in PICALM gene. | Ponomareva NV et al. | β | 2017 | β |
| Cognitive, emotion control, and motor performance of adolescents in the NCANDA study: Contributions from alcohol consumption, age, sex, ethnicity, and family history of addiction. | Sullivan EV et al. | β | 2016 | β |
| "Cognitive, emotion control, and motor performance of adolescents in the NCANDA study: Contributions from alcohol consumption, age, sex, ethnicity, and family history of addiction": Correction to Sullivan et al. (2016). | β | β | 2016 | β |
| Epileptic Electroencephalography Profile Associates with Attention Problems in Children with Fragile X Syndrome: Review and Case Series. | Cowley B et al. | β | 2016 | β |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | β | 2016 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. | Kamarajan C et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | β | 2015 | β |
| Alcohol and the sleeping brain. | Colrain IM et al. | β | 2014 | β |
| Alcohol reduces cross-frequency theta-phase gamma-amplitude coupling in resting electroencephalography. | Lee J et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Oscillatory spatial profile of alcohol's effects on the resting state: anatomically-constrained MEG. | Rosen BQ et al. | β | 2014 | β |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | β | 2014 | β |
| A review of gamma oscillations in healthy subjects and in cognitive impairment. | BaΕar E | β | 2013 | β |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | β | 2013 | β |
| Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. | Wiggins WF et al. | β | 2013 | β |
| Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. | Perry BL et al. | β | 2013 | β |
| Acute alcohol effects on contextual memory BOLD response: differences based on fragmentary blackout history. | Wetherill RR et al. | β | 2012 | β |
| Adolescence and parental history of alcoholism: insights from the sleep EEG. | Tarokh L et al. | β | 2012 | β |
| Family-based genome-wide association study of frontal ΞΈ oscillations identifies potassium channel gene KCNJ6. | Kang SJ et al. | β | 2012 | β |
| Frontoparietal connectivity in substance-naΓ―ve youth with and without a family history of alcoholism. | Wetherill RR et al. | β | 2012 | β |
| Impaired generalization of associative learning in patients with alcohol dependence after intermediate-term abstinence. | MΓ‘ttyΓ‘ssy A et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| Topography, power, and current source density of ΞΈ oscillations during reward processing as markers for alcohol dependence. | Kamarajan C et al. | β | 2012 | β |
| An overview of the genetic susceptibility to alcoholism. | Buscemi L et al. | β | 2011 | β |
| Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential. | Iacono WG et al. | β | 2011 | β |
| Disrupted thalamic T-type Ca2+ channel expression and function during ethanol exposure and withdrawal. | Graef JD et al. | β | 2011 | β |
| Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder. | Tye C et al. | β | 2011 | β |
| Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. | Gilmore CS et al. | β | 2010 | β |
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | Kamarajan C et al. | β | 2010 | β |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | β | 2010 | β |
| Neural plasticity, human genetics, and risk for alcohol dependence. | Hill SY | β | 2010 | β |
| Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology. | Gilmore CS et al. | β | 2010 | β |
| Sleep electroencephalogram in children with a parental history of alcohol abuse/dependence. | Tarokh L et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | β | 2009 | β |
| Typologies of alcohol dependence. From Jellinek to genetics and beyond. | Leggio L et al. | β | 2009 | β |
| A review of brain oscillations in cognitive disorders and the role of neurotransmitters. | BaΕar E et al. | β | 2008 | β |
| Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. | Spadoni AD et al. | β | 2008 | β |
| From event-related potential to oscillations: genetic diathesis in brain (dys)function and alcohol dependence. | Rangaswamy M et al. | β | 2008 | β |
| The role of selected factors in the development and consequences of alcohol dependence. | Gilbertson R et al. | β | 2008 | β |
| Theta oscillations during the processing of monetary loss and gain: a perspective on gender and impulsivity. | Kamarajan C et al. | β | 2008 | β |
| Translational studies of alcoholism: bridging the gap. | Zahr NM et al. | β | 2008 | β |
| Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. | Rangaswamy M et al. | β | 2008 | β |