Family history of alcohol use disorders and neuromaturation: a functional connectivity study with adolescents.
- Authors
- Spadoni, Andrea D; Simmons, Alan N; Yang, Tony T; Tapert, Susan F
- Year
- 2013
- Journal
- The American journal of drug and alcohol abuse
- PMID
- 24200205
- DOI
- 10.3109/00952990.2013.818680
- PMCID
- PMC3959877
BACKGROUND: A positive family history (FHP) of alcohol use disorders (AUD) is linked to increased risk for personal AUD, but the mechanisms behind this risk are unclear. Previous research suggests that a subtle neurodevelopmental lag in FHP adolescents may contribute to risk for future AUD. METHODS: Functional magnetic resonance imaging (fMRI) response to a spatial working memory (SWM) task was examined for markers of neuromaturational delay in 85 youth with and without FHP. It was hypothesized that FHP adolescents (n = 24, ages 12-14 years), as compared to matched FHN youth (n = 26, ages 12-14 years), would show less similarity to brain connectivity observed in older adolescents (n = 35, ages 16-20 years) and that statistical comparison of SWM functional connectivity models would differentiate FHN and FHP youth. Structural equation modeling tested the fit of brain response connectivity between FH groups and against the older-adolescent model. RESULTS: Patterns of connectivity were more similar between older adolescent and FHN than FHP adolescents; FHP youth demonstrated higher association between right posterior and left frontal brain regions than FHN and older adolescent youth. Comparison of FH groups indicated a significant difference on the pathway from the right superior parietal lobule to the left middle frontal gyrus. CONCLUSIONS: These findings provide additional support for the notion of a neuromaturational lag in FHP youth. Protracted neuromaturation may be a mechanism by which FH increases risk for alcohol dependence, and this less mature neural connectivity pattern may provide a novel endophenotype for identifying youth at risk for drinking problems.
Hypothesized Model of Functional Connectivity for older adolescents to be validated and compared to family history groups. The model of brain activity during spatial working memory was developed to include brain regions that best approximate patterns previously reported for older adolescents and adults in response to a spatial working memory imaging task. Regions of interest (ROIs) included: 1) right inferior parietal lobule, 2) right superior parietal lobule, 3) right middle frontal gyrus, and 4) left middle frontal gyrus.
Spatial working memory task design. The spatial working memory task consists of 18 20-sec blocks alternating between experimental (spatial working memory) and baseline (vigilance) conditions. In both conditions, stimuli were presented for 1000 ms, and each interstimulus interval is 1000 ms (20 sec/block, repetition time (TR) = 3000 ms, 156 repetitions).
The results of fitting the covariance matrix to the proposed model in OA youth. Pathways labeled with unstandardized (and standardized in parentheses) coefficients (p<.05) and disturbances (D) with standard error terms for endogenous variables.
Best fitting FHN youth mode (LEFT); Best fitting FHP youth model (RIGHT); Pathways labeled with unstandardized (and standardized in parentheses) coefficients (p<.05) and disturbances (D) with standard error terms for endogenous variables.
| Name | Type |
|---|---|
| 12-14 year-olds local | cohort |
| adolescents | cohort |
| age | phenotype |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| alcohol-related diseases | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| amygdala | anatomy |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| AUD | phenotype |
| Bilateral pathway (right superior parietal lobule – left middle frontal gyrus) local | anatomy |
| bipolar I disorder | phenotype |
| Body sway | phenotype |
| BOLD response | phenotype |
| cerebellar region | anatomy |
| cerebellar regions local | anatomy |
| cigarettes | phenotype |
| cingulate cortex | anatomy |
| decreased frontal-parietal connectivity local | phenotype |
| Delayed maturation of postural sway local | phenotype |
| depression | phenotype |
| Dorsal Stream local | anatomy |
| dorsolateral prefrontal cortex | anatomy |
| Drug use during pregnancy local | drug |
| family history negative | phenotype |
| Family History Negative youth local | cohort |
| family history of alcoholism | phenotype |
| family history positive | phenotype |
| Family History Positive group local | cohort |
| FH effects local | phenotype |
| FHN | cohort |
| FHN participants | cohort |
| FHN youth local | cohort |
| FHP | cohort |
| FHP youth | cohort |
| FH status local | phenotype |
| frontal cortex | anatomy |
| Frontal Orbital Cortex local | anatomy |
| fronto-parietal network | anatomy |
| Frontoparietal pathways local | anatomy |
| Head injury | phenotype |
| heavy drinking | phenotype |
| Herting et al., 2011 local | cohort |
| increased frontal-parietal connectivity local | phenotype |
| increased nucleus accumbens connectivity local | phenotype |
| inferior parietal lobe | anatomy |
| inhibitory control | phenotype |
| insular region local | anatomy |
| intracranial volume | anatomy |
| learning disabilities | phenotype |
| Left-handedness | phenotype |
| left middle frontal gyrus | anatomy |
| lentiform nucleus | anatomy |
| marijuana | phenotype |
| Maternal drinking local | drug |
| medial frontal cortex | anatomy |
| medical problems | phenotype |
| MRI contraindications | phenotype |
| Negative family history local | cohort |
| neurocognition local | phenotype |
| neurodevelopment | phenotype |
| Neurodevelopmental delay local | phenotype |
| Neurological problems local | phenotype |
| neuromaturation local | phenotype |
| non-FHP youth local | cohort |
| nucleus accumbens | anatomy |
| OA | phenotype |
| OA group local | cohort |
| OA validation sample local | cohort |
| OA youth local | cohort |
| Offspring of Alcoholics group local | cohort |
| older cohort | cohort |
| P300 amplitude | phenotype |
| parietal cortex | anatomy |
| Participating family members local | cohort |
| posterior parietal areas local | anatomy |
| posterior parietal region local | anatomy |
| prefrontal cortex | anatomy |
| problematic alcohol use | phenotype |
| protracted neuromaturation local | phenotype |
| psychiatric disorders | phenotype |
| psychosis | phenotype |
| psychotropic medication | drug |
| Reduced amygdala volume local | phenotype |
| reduced fronto-cerebellar connectivity local | phenotype |
| Reduced intracranial volume local | phenotype |
| right inferior parietal lobule | anatomy |
| right middle frontal gyrus | anatomy |
| right superior parietal cortex local | anatomy |
| right superior parietal lobule local | anatomy |
| Right superior parietal lobule local | anatomy |
| Right Superior Parietal Lobule local | anatomy |
| right superior parietal node local | anatomy |
| ROI | anatomy |
| sensorimotor cortex | anatomy |
| sensory deficits | phenotype |
| spatial working memory | phenotype |
| superior parietal cortex | anatomy |
| SWM | phenotype |
| SWM accuracy local | phenotype |
| SWM accuracy scores local | phenotype |
| SWM task performance local | phenotype |
| ventrolateral prefrontal cortex | anatomy |
| vigilance | phenotype |
| vigilance baseline condition local | phenotype |
| vigilance reaction time local | phenotype |
| visual working memory | phenotype |
| Weliand et al., 2013 local | cohort |
| Wetherill et al., 2011 local | cohort |
| Wetherill et al., 2012 local | cohort |
| younger cohort | cohort |
| Youth (12-17) local | cohort |
| Youth with positive family history of AUD local | cohort |
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|---|---|---|---|---|
| Neural correlates associated with a family history of alcohol use disorder: A narrative review of recent findings. | Cservenka A et al. | — | 2025 | → |
| Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder. | Schilling L et al. | — | 2025 | → |
| Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy. | Del Cerro-León A et al. | — | 2024 | → |
| Associations Between Family History of Alcohol and/or Substance Use Problems and Frontal Cortical Development From 9 to 13 Years of Age: A Longitudinal Analysis of the ABCD Study. | Gonçalves PD et al. | — | 2024 | → |
| Neural activations during cognitive and affective theory of mind processing in healthy adults with a family history of alcohol use disorder. | Schmid F et al. | — | 2024 | → |
| Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth. | Auerbach RP et al. | — | 2021 | → |
| Risk and resilience for alcohol use disorder revealed in brain functional connectivity. | Elton A et al. | — | 2021 | → |
| The Development of Impulsivity and Sensation Seeking: Associations with Substance Use among At-Risk Adolescents. | Wasserman AM et al. | — | 2020 | → |
| Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence. | Vaidya JG et al. | — | 2019 | → |
| Earlier alcohol use onset prospectively predicts changes in functional connectivity. | Nguyen-Louie TT et al. | — | 2018 | → |
| Disrupted resting brain graph measures in individuals at high risk for alcoholism. | Holla B et al. | — | 2017 | → |
| Neurobiological phenotypes associated with a family history of alcoholism. | Cservenka A | — | 2016 | → |
| Neurobiological signatures associated with alcohol and drug use in the human adolescent brain. | Silveri MM et al. | — | 2016 | → |
| Advances in Human Neuroconnectivity Research: Applications for Understanding Familial History Risk for Alcoholism. | Cservenka A et al. | — | 2015 | → |
| Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism. | Peraza J et al. | — | 2015 | → |
| Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. | Kamarajan C et al. | — | 2015 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls. | Cservenka A et al. | — | 2015 | → |
| Family history of alcoholism and brain activation: commentary on "Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/No-Go task". | Colrain IM | — | 2015 | → |
| MoCA as a Screening Tool of Neuropsychological Deficits in Alcohol-Dependent Patients. | Alarcon R et al. | — | 2015 | → |
| The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth. | Ewing SW et al. | — | 2014 | → |