Biological parents’ and grandparents’ lifetime history of AUD was obtained from both parents and participant using the Family History Assessment Module screener (FHAM) (49) and Schuckit's Problem List (4). Most participants had 2 biological parents as informants, and all participants had at least one. Of the FHP group, 100% had a parent with an AUD history, 79% had a multigenerational history, 63% had a biological father with a history of AUD, 46% had a biological mother with a history of AUD, 8% had positive history in both parents, and one subject had a history of AUD solely in their biological mother. Of the OA group, 14% had a parent with an AUD history, and 11% had a multigenerational history. FHN youth had no history of any substance use disorder in parents or grandparents.