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Chunk #12 — METHODS — Data Analysis and Statistics — Image processing

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Family history of alcohol use disorders and neuromaturation: a functional connectivity study with adolescents.
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Data were processed and analyzed using Analysis of Functional NeuroImages (AFNI; afni.nimh.nih.gov) (55). Motion in the time series data was corrected by registering each acquisition to a selected repetition with an iterated least squares algorithm (56) to estimate three rotational and three displacement parameters for each participant. We excluded 1) all brain volumes where rigid motion exceeded 3mm (i.e., voxel width) allowing us to maintain a 90% power threshold, 2) and individuals whose performance on the SWM task fell outside 3 SD from the mean (n=3). An output file specifying adjustments made was used to control for spin history effects (57). In addition, applied adjustments were compared between groups, and correlated with the task reference vector to see if motion indices needed to be corrected in subsequent analyses.