Brain response during SWM may provide an opportunity to observe a hypothesized neurodevelopmental lag in FHP youth, as the developmental trajectory of frontoparietal pathways invoked to complete SWM tasks may be moderated by premorbid family history effects (18, 23, 30). Specifically, the underlying neural substrates of SWM appear to develop during adolescence, shifting more posterior and lateralizing to the right side, while the inferior parietal lobe becomes more important to task success (31-37). Thus, examination of FH effects on neural networks supporting SWM during the appropriate developmental window may elucidate whether a positive FH of AUD moderates the typical trajectory of neurodevelopment.
