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Chunk #12 — 3. Discussion

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Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism.
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in PPC to DLPFC) than their FHN counterparts. Follow-up correlation analyses revealed that functional connectivity between the PPC and DLPFC was negatively associated with number of missed responses during a supra-span visual working memory task, specifically among substance-naïve FHN youth. As such, stronger functional connectivity among FHN youth improved overall attention during the task and suggests that weaker frontoparietal connectivity among FHP youth may underlie attentional deficits observed among FHP youth (Knopik et al., 2009), placing them at higher risk for developing attention-deficit/hyperactivity disorder (ADHD; Bush, 2011).