The current study expands on the existing literature by examining frontoparietal network functioning and integrity in substance-naïve FHP youth and matched controls with no family history of alcoholism (FHN), using functional connectivity MRI (fcMRI) and diffusion tensor imaging (DTI). fcMRI encompasses a variety of analytic approaches (Zhou et al., 2009), including the zero-order temporal correlation between the blood oxygen level dependent (BOLD) time series signal of a designated seed region and all other voxels in the brain (Biswal et al., 1995; 1997). These correlations can be used to create a map representing functionally-related neural activity in spatially segregated brain regions (Leopold et al., 2003a, b). Thus, fcMRI measures the degree to which anatomically distinct brain regions form coherent functional networks (Deco et al., 2011).
