We examined fcMRI and underlying white matter microstructure in specific frontoparietal areas subserving working memory (PPC and DLPFC; Spadoni et al., 2008; Tapert et al., 2004) in substance-naïve FHP and FHN youth. Based on neurobiological and neurobehavioral differences observed in FHP youth, we hypothesized that FHP youth would show weaker frontoparietal connectivity and white matter fiber tract organization and integrity than FHN youth.
