Comparison of direct interview and family history diagnoses of alcohol dependence.
paper
Primary
Public
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- Authors
- Rice, J P; Reich, T; Bucholz, K K; Neuman, R J; Fishman, R; Rochberg, N; Hesselbrock, V M; Nurnberger, J I; Schuckit, M A; Begleiter, H
- Year
- 1995
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 7485811
- DOI
- 10.1111/j.1530-0277.1995.tb00983.x
Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second-degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
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| Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence. | Jacobus J et al. | — | 2014 | → |
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| Heavy alcohol use, marijuana use, and concomitant use by adolescents are associated with unique and shared cognitive decrements. | Winward JL et al. | — | 2014 | → |
| Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task. | Acheson A et al. | — | 2014 | → |
| Inhibition during early adolescence predicts alcohol and marijuana use by late adolescence. | Squeglia LM et al. | — | 2014 | → |
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| Sex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone. | Alarcón G et al. | — | 2014 | → |
| Sweet-liking is associated with transformation of heavy drinking into alcohol-related problems in young adults with high novelty seeking. | Kampov-Polevoy A et al. | — | 2014 | → |
| The patterns of drug and alcohol use and associated problems over 30 years in 397 men. | Schuckit MA et al. | — | 2014 | → |
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| A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART. | Bauer LO | — | 2013 | → |
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| A Positive Association between T. gondii Seropositivity and Obesity. | Reeves GM et al. | — | 2013 | → |
| Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: results from a large multicenter association study. | Preuss UW et al. | — | 2013 | → |
| Atypical neural activity during inhibitory processing in substance-naïve youth who later experience alcohol-induced blackouts. | Wetherill RR et al. | — | 2013 | → |
| Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism. | Mackiewicz Seghete KL et al. | — | 2013 | → |
| Characterizing alcohol use disorders and suicidal ideation in young women. | Agrawal A et al. | — | 2013 | → |
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| Differences in brain activity during a verbal associative memory encoding task in high- and low-fit adolescents. | Herting MM et al. | — | 2013 | → |
| Differential brain response to alcohol cue distractors across stages of alcohol dependence. | Fryer SL et al. | — | 2013 | → |
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| Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253. | Donohoe G et al. | — | 2013 | → |
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| White matter integrity pre- and post marijuana and alcohol initiation in adolescence. | Jacobus J et al. | — | 2013 | → |
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| Aerobic fitness relates to learning on a virtual Morris Water Task and hippocampal volume in adolescents. | Herting MM et al. | — | 2012 | → |
| Alcohol increases impulsivity and abuse liability in heavy drinking women. | Reed SC et al. | — | 2012 | → |
| Altered cerebral blood flow and neurocognitive correlates in adolescent cannabis users. | Jacobus J et al. | — | 2012 | → |
| Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism. | Cservenka A et al. | — | 2012 | → |
| Binge drinking differentially affects adolescent male and female brain morphometry. | Squeglia LM et al. | — | 2012 | → |
| Brain response to working memory over three years of adolescence: influence of initiating heavy drinking. | Squeglia LM et al. | — | 2012 | → |
| Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults. | Mingione CJ et al. | — | 2012 | → |
| Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia. | Kästner A et al. | — | 2012 | → |
| Comparison of alcoholism subtypes as moderators of the response to sertraline treatment. | Kranzler HR et al. | — | 2012 | → |
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| GABRA2 and KIBRA genotypes predict early relapse to substance use. | Bauer LO et al. | — | 2012 | → |
| GABRA2 genotype, impulsivity, and body mass. | Bauer LO et al. | — | 2012 | → |
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| Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms. | Koller G et al. | — | 2012 | → |
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| The impact of sex, puberty, and hormones on white matter microstructure in adolescents. | Herting MM et al. | — | 2012 | → |
| The interpretability of family history reports of alcoholism in general community samples: findings in a midwestern U.S. twin birth cohort. | Waldron M et al. | — | 2012 | → |
| The next generation of psychological autopsy studies: part 2. Interview procedures. | Conner KR et al. | — | 2012 | → |
| Adolescent binge drinking linked to abnormal spatial working memory brain activation: differential gender effects. | Squeglia LM et al. | — | 2011 | → |
| Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance. | Silveri MM et al. | — | 2011 | → |
| Alterations of the early auditory evoked gamma-band response in first-degree relatives of patients with schizophrenia: hints to a new intermediate phenotype. | Leicht G et al. | — | 2011 | → |
| Altered fronto-cerebellar connectivity in alcohol-naïve youth with a family history of alcoholism. | Herting MM et al. | — | 2011 | → |
| Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. | Preuss UW et al. | — | 2011 | → |
| Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology. | Braunewell KH et al. | — | 2011 | → |
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| Smoking history, nicotine dependence, and changes in craving and mood during short-term smoking abstinence in alcohol dependent vs. control smokers. | Heffner JL et al. | — | 2011 | → |
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| Analgesic effects of ethanol are influenced by family history of alcoholism and neuroticism. | Ralevski E et al. | — | 2010 | → |
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| No association of alcohol dependence with HOMER 1 and 2 genetic variants. | Preuss UW et al. | — | 2010 | → |
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| Reduced early auditory evoked gamma-band response in patients with schizophrenia. | Leicht G et al. | — | 2010 | → |
| Relationship between cigarette smoking and childhood symptoms of inattention and hyperactivity/impulsivity in alcohol-dependent adults without attention-deficit hyperactivity disorder. | Heffner JL et al. | — | 2010 | → |
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| White matter integrity in adolescents with histories of marijuana use and binge drinking. | Jacobus J et al. | — | 2009 | → |
| Abstinent adolescent marijuana users show altered fMRI response during spatial working memory. | Schweinsburg AD et al. | — | 2008 | → |
| A family history of psychopathology modifies the decrement in cognitive control among patients with HIV/AIDS. | Bauer LO | — | 2008 | → |
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| Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers. | Juckel G et al. | — | 2008 | → |
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| Prevalence of domestic violence and associated factors among women on a trauma service. | Melnick DM et al. | — | 2002 | → |
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| A bootstrapped commingling analysis of platelet monoamine oxidase activity levels corrected for cigarette smoking. | Daw EW et al. | — | 2001 | → |
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