Electrophysiological effects of dizocilpine (MK-801) in adult rats exposed to ethanol during adolescence.
- Authors
- Criado, José R; Wills, Derek N; Walker, Brendan M; Ehlers, Cindy L
- Year
- 2008
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 18652596
- DOI
- 10.1111/j.1530-0277.2008.00760.x
BACKGROUND: Despite evidence showing persistent changes in N-methyl-D-aspartate (NMDA)-receptor function following ethanol (EtOH) exposure, the contribution of NMDA systems to the long-term neurophysiological consequences of adolescent EtOH exposure is unclear. The aims of this study were the following: (1) to determine whether adolescent EtOH exposure produces neurophysiological changes after a prolonged withdrawal period in adult rats and (2) to assess protracted alterations in neurophysiological responses to the NMDA antagonist MK-801 in adult rats exposed to EtOH during adolescence. METHODS: Adolescent male Wistar rats were exposed to EtOH vapor for 12 h/d for 5 weeks. The effects of MK-801 (0.0 to 0.1 mg/kg, intraperitoneally) on the electroencephalogram (EEG) and auditory event-related potentials (ERPs) were assessed after 8 weeks of abstinence from EtOH. RESULTS: Experiments in aim 1 revealed that adolescent EtOH exposure reduced EEG variability in the frontal cortex in the 4 to 6 Hz band but had no effect on cortical and hippocampal EEG power and ERPs. Experiments in aim 2 showed that MK-801 significantly reduced EEG power in the parietal cortex (4 to 6 Hz, 6 to 8 Hz, 8 to 16 Hz, 16 to 32 Hz) and hippocampus (16 to 32 Hz) and EEG variability in the parietal cortex (6 to 8 Hz, 16 to 32 Hz) following adolescent EtOH exposure. MK-801 produced a significant decrease in hippocampal EEG variability (4 to 6 Hz, 8 to 16 Hz, 16 to 32 Hz) in control, but not in EtOH-exposed rats. MK-801 reduced frontal P1 ERP amplitude and latency in response to the rare tone in EtOH-exposed rats compared to controls. In contrast, MK-801 significantly reduced P3 ERP amplitude and latency in control, but not in EtOH-exposed rats. CONCLUSIONS: The effects of MK-801 on hippocampal EEG variability and P3 ERP amplitude and latency are significantly attenuated after a prolonged withdrawal period following adolescent EtOH exposure. However, the inhibitory effects of MK-801 on cortical and hippocampal EEG power were enhanced in rats exposed to EtOH during adolescence. Taken together, these data suggest protracted changes in NMDA systems following adolescent EtOH exposure.
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External
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|---|---|---|---|---|
| Use of a Fitbit-like device in rats: Sex differences, relation to EEG sleep, and use to measure the long-term effects of adolescent ethanol exposure. | Ehlers CL et al. | — | 2023 | → |
| PSPH-D-18-00526: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence. | Ehlers CL et al. | — | 2020 | → |
| Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats. | Amodeo LR et al. | — | 2017 | → |
| Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. | Prins SA et al. | — | 2014 | → |
| Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence. | Cuzen NL et al. | — | 2013 | → |
| Effects of adolescent onset voluntary drinking followed by ethanol vapor exposure on subsequent ethanol consumption during protracted withdrawal in adult Wistar rats. | Criado JR et al. | — | 2013 | → |
| Hippocampal volumes and cognitive functions in adult alcoholic patients with adolescent-onset. | Ozsoy S et al. | — | 2013 | → |
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| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | — | 2012 | → |
| Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats. | Criado JR et al. | — | 2011 | → |
| Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? | Ehlers CL et al. | — | 2010 | → |
| Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats. | Criado JR et al. | — | 2010 | → |
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| Research on alcohol and adolescent brain development: opportunities and future directions. | Witt ED | — | 2010 | → |
| Milk consumption during adolescence decreases alcohol drinking in adulthood. | Pian JP et al. | — | 2009 | → |
| Effects of adolescent ethanol exposure on sleep in adult rats. | Criado JR et al. | — | 2008 | → |