Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis.
- Authors
- Hill, Shirley Y; Shen, Sa
- Year
- 2002
- Journal
- Biological psychiatry
- PMID
- 11955462
- DOI
- 10.1016/s0006-3223(01)01301-4
- PMCID
- PMC3298999
BACKGROUND: The P3b component of the event-related potential (ERP) has frequently been reported to be reduced in children and adolescents at high risk for developing alcoholism relative to control children and adolescents without familial loading for alcohol dependence. P300 amplitude changes during development for all children. Previously it has been shown that high-risk offspring display a pattern in which the amplitude is lower at age 8 with a smaller rate of change during adolescence. METHODS: Admixture analysis was applied to data obtained for those children and adolescents having five or more annual assessments of ERPs to determine if multiple P3b growth patterns exist. The P3b amplitude patterns obtained were related to risk status, concurrent presence of childhood psychopathology (internalizing or externalizing), and age of onset to develop a diagnosis. RESULTS: A pattern characterized by lower P3b amplitude at study entry and a slower rate of change during child and adolescent development (pattern 3) was most often associated with high-risk status in boys and high-risk status in combination with the presence of a childhood diagnosis in girls. Pattern 3 was significantly related to the overall presence of childhood psychopathology (internalizing or externalizing) and to the presence of an Axis I diagnosis at young adult follow-up. CONCLUSIONS: The developmental pattern previously described for offspring at high risk for developing alcoholism because of their familial/genetic background was confirmed. Admixture analysis has refined this observation and suggests that among all children and adolescents tested, three developmental patterns can be identified, one of which is most often seen in association with male high-risk children and adolescents.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Evaluation of P300 Response Through the Visual Oddball Paradigm in Healthy Children and Adolescents. | Gupta S et al. | — | 2025 | → |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | — | 2022 | → |
| Cognitive Control Deficits in Alcohol Dependence Are a Trait- and State-Dependent Biomarker: An ERP Study. | Liu X et al. | — | 2020 | → |
| Neural anomalies during vigilance in schizophrenia: Diagnostic specificity and genetic associations. | Klein SD et al. | — | 2020 | → |
| P300 development from infancy to adolescence. | Riggins T et al. | — | 2020 | → |
| Development of the P300 from childhood to adulthood: a multimodal EEG and MRI study | Overbye K et al. | — | 2018 | — |
| Development of the P300 from childhood to adulthood: a multimodal EEG and MRI study. | Overbye K et al. | — | 2018 | → |
| Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. | Crews FT et al. | — | 2016 | → |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | — | 2016 | → |
| Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth. | Hill SY et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| Genetic psychophysiology: advances, problems, and future directions. | Anokhin AP | — | 2014 | → |
| Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence. | Cuzen NL et al. | — | 2013 | → |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | — | 2013 | → |
| Evidence for a Heritable Brain Basis to Deviance-Promoting Deficits in Self-Control. | Yancey JR et al. | — | 2013 | → |
| White matter microstructure, alcohol exposure, and familial risk for alcohol dependence. | Hill SY et al. | — | 2013 | → |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | — | 2012 | → |
| Reconceptualizing antisocial deviance in neurobehavioral terms. | Patrick CJ et al. | — | 2012 | → |
| Recreational gamblers with and without parental addiction. | Schreiber LR et al. | — | 2012 | → |
| Alcohol effects on cerebral blood flow in subjects with low and high responses to alcohol. | Tolentino NJ et al. | — | 2011 | → |
| Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? | Ehlers CL et al. | — | 2010 | → |
| Electrophysiological changes during adolescence: a review. | Segalowitz SJ et al. | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Neural plasticity, human genetics, and risk for alcohol dependence. | Hill SY | — | 2010 | → |
| D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics. | Antolin T et al. | — | 2009 | → |
| Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. | Duncan CC et al. | — | 2009 | → |
| Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology. | Carlson SR et al. | — | 2008 | → |
| The role of selected factors in the development and consequences of alcohol dependence. | Gilbertson R et al. | — | 2008 | → |
| Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence. | Venkatasubramanian G et al. | — | 2007 | → |
| Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. | Benegal V et al. | — | 2007 | → |
| Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children. | Stieben J et al. | — | 2007 | → |
| P3 components and adolescent binge drinking in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| A cholinergic receptor gene (CHRM2) affects event-related oscillations. | Jones KA et al. | — | 2006 | → |
| Association of DRD4 exon III polymorphism with auditory P300 amplitude in 8-year-old children. | Vogel CI et al. | — | 2006 | → |
| Heritability and reliability of P300, P50 and duration mismatch negativity. | Hall MH et al. | — | 2006 | → |
| Heritability of P300 amplitude development from adolescence to adulthood. | Carlson SR et al. | — | 2006 | → |
| P300 amplitude as an indicator of externalizing in adolescent males. | Patrick CJ et al. | — | 2006 | → |
| P300 development during adolescence: effects of DRD2 genotype. | Berman SM et al. | — | 2006 | → |
| Sex-related lateralized effect of emotional content on declarative memory: an event related potential study. | Gasbarri A et al. | — | 2006 | → |
| Borderline personality disorder features in adolescent girls: P300 evidence of altered brain maturation. | Houston RJ et al. | — | 2005 | → |
| Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2005 | → |
| The human adolescent brain and alcohol use disorders. | Tapert SF et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Adolescence and the trajectory of alcohol use: basic to clinical studies. | Brown SA et al. | — | 2004 | → |
| A genome wide search for alcoholism susceptibility genes. | Hill SY et al. | — | 2004 | → |
| Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. | Houston RJ et al. | — | 2004 | → |
| Depression and familial risk for substance dependence: a P300 study of young women. | Houston RJ et al. | — | 2003 | → |
| Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics. | Berman SM et al. | — | 2003 | → |
| Substance abuse-related P300 differences in response to an implicit memory task. | Ceballos NA et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |