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Chunk #14 — Materials and Methods — EEG and Statistical Analysis

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Absence of P300 reduction in South African treatment-naïve adolescents with alcohol dependence.
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We used the BrainVision Analyzer package (BVA; Brain Products, 2008) for ERP processing. Eye movement artifacts were removed using the Gratton and Coles method (Gratton et al., 1983). Data were then band-pass filtered between 0.5 and 15 Hz using a zero-phase lag filter at 48 dB/octave. Data were re-referenced to the right mastoid. Stimulus-locked trials were extracted for all instances where there was a correct behavioral response for the standard, target and rare non-target conditions, with each trial comprising 100 ms of data pre-stimulus and 750 ms post-stimulus. The trials were baseline corrected using the 100 ms pre-stimulus interval. Any trials with out-of-range voltages (± 75 mV) were rejected as artifact and excluded from further processing. If fewer than 21 trials per condition (standard, target, or distracter) remained for any subject following artifact rejection, that subject’s data were eliminated from the analysis. On this basis, data from 1 NSAC and 7 TNAD participants were eliminated, leaving a final sample size of N = 109 (45 TNAD (30 females) and 64 NSAC (38 females)).