Visual P3a in male alcoholics and controls.
- Authors
- Rodriguez Holguin, S; Porjesz, B; Chorlian, D B; Polich, J; Begleiter, H
- Year
- 1999
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 10235292
The goal of this study was to assess the P3a component of event-related potentials in a population of abstinent, chronic alcoholics. A three-stimulus visual oddball paradigm was used to elicit robust P3a components in a large group of well-characterized male alcoholics (n = 44) and controls (n = 28). The task required subjects to make a difficult perceptual discrimination between randomly presented, frequently occurring vertical lines (.80) and infrequent target lines that were tilted 2 degrees to the right of vertical (.10) by only responding with a button press to the target stimuli. A nontarget infrequent horizontal line occurred (.10) randomly to which no response was made. The target stimulus elicited robust late P3b components with a parietal maximum amplitude, and the nontarget stimulus elicited reliable P3a components with a fronto-central maximum amplitude distribution. Group differences in P3a were assessed using repeated measures ANCOVA analyses in five scalp regions. Alcoholic subjects produced smaller P3a amplitudes over the central, parietal, temporal, and occipital areas compared with controls. Current source density analyses supported these findings with extension of the differences between the groups to the frontal region. The results suggest that the P3a may be important in the evaluation of alcoholism and its heritability. Theoretical implications are discussed.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Electrophysiological indexes for impaired response inhibition and salience attribution in substance (stimulants and depressants) use disorders: A meta-analysis. | Zhang Y et al. | β | 2021 | β |
| Modulation of responses to visual stimulus onset and offset by chronic alcohol consumption and withdrawal in the rat visual cortex and lateral geniculate nucleus. | Dulinskas R et al. | β | 2020 | β |
| One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study. | Burwell SJ et al. | β | 2016 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Family history of alcoholism and brain activation: commentary on "Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/No-Go task". | Colrain IM | β | 2015 | β |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | β | 2015 | β |
| The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. | Kamarajan C et al. | β | 2015 | β |
| Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice. | Riegle MA et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Neural correlates of performance monitoring in daily and intermittent smokers. | Rass O et al. | β | 2014 | β |
| Absence of P300 reduction in South African treatment-naΓ―ve adolescents with alcohol dependence. | Cuzen NL et al. | β | 2013 | β |
| Behavioral control in alcohol use disorders: relationships with severity. | Claus ED et al. | β | 2013 | β |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | β | 2013 | β |
| Effects of a persistent binge drinking pattern of alcohol consumption in young people: a follow-up study using event-related potentials. | LΓ³pez-Caneda E et al. | β | 2013 | β |
| Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. | Wiggins WF et al. | β | 2013 | β |
| Meta-analytic review of P3 components in posttraumatic stress disorder and their clinical utility. | Johnson JD et al. | β | 2013 | β |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | β | 2012 | β |
| Neuropsychological and neurophysiological assessment of sport concussion in children, adolescents and adults. | Baillargeon A et al. | β | 2012 | β |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | β | 2012 | β |
| Topography, power, and current source density of ΞΈ oscillations during reward processing as markers for alcohol dependence. | Kamarajan C et al. | β | 2012 | β |
| A longitudinal twin study of effects of adolescent alcohol abuse on the neurophysiology of attention and orienting. | Koskinen SM et al. | β | 2011 | β |
| Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects. | Colrain IM et al. | β | 2011 | β |
| Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm. | Roopesh BN et al. | β | 2010 | β |
| Binge drinking affects attentional and visual working memory processing in young university students. | Crego A et al. | β | 2009 | β |
| Electrophysiological correlates of the disrupted processing of anger in alcoholism. | Maurage P et al. | β | 2008 | β |
| Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain". | Sullivan EV et al. | β | 2008 | β |
| Is the P300 deficit in alcoholism associated with early visual impairments (P100, N170)? An oddball paradigm. | Maurage P et al. | β | 2007 | β |
| Long-term electrophysiological changes in athletes with a history of multiple concussions. | De Beaumont L et al. | β | 2007 | β |
| Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. | Padmanabhapillai A et al. | β | 2006 | β |
| Visual P300s in long-term abstinent chronic alcoholics. | Fein G et al. | β | 2006 | β |
| Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task. | Kamarajan C et al. | β | 2005 | β |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | β | 2005 | β |
| Alcoholism risk, tobacco smoking, and P300 event-related potential. | Polich J et al. | β | 2004 | β |
| Clinical application of the P300 event-related brain potential. | Polich J | β | 2004 | β |
| Abnormal CNV in chronic heavy drinkers. | Chao LL et al. | β | 2003 | β |
| Alcoholism risk and the P300 event-related brain potential: modality, task, and gender effects. | Reese C et al. | β | 2003 | β |
| Electrophysiological evidence of abnormal activation of the cerebral network of involuntary attention in alcoholism. | Polo MD et al. | β | 2003 | β |
| Substance abuse-related P300 differences in response to an implicit memory task. | Ceballos NA et al. | β | 2003 | β |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | β | 2003 | β |
| Alcohol-related ERP changes recorded from different modalities: a topographic analysis. | Cohen HL et al. | β | 2002 | β |
| Auditory P3a deficits in male subjects at high risk for alcoholism. | Hada M et al. | β | 2001 | β |
| Auditory P3a assessment of male alcoholics. | Hada M et al. | β | 2000 | β |
| Multivariate genetic analysis of brain structure in an extended twin design. | Posthuma D et al. | β | 2000 | β |
| Visual P3a in male subjects at high risk for alcoholism. | RodrΓguez HolguΓn S et al. | β | 1999 | β |