Absence of visual and auditory P300 reduction in nondepressed male and female alcoholics.
- Authors
- Hill, S Y; Locke, J; Steinhauer, S R
- Year
- 1999
- Journal
- Biological psychiatry
- PMID
- 10509181
- DOI
- 10.1016/s0006-3223(99)00054-2
BACKGROUND: The P300 component of the event-related potential has been extensively studied as a possible neurobiological risk marker for the development of alcoholism. Although P300 amplitude reduction has frequently been documented in high-risk children, studies of adult alcoholics are inconsistent. METHODS: P300 amplitude from 121 adult alcoholics was compared to 68 controls utilizing event-related potential paradigms from the auditory and visual modalities. All participants were evaluated clinically with psychiatric interviews and administered the MMPI. RESULTS: Male alcoholics did not show a reduction in amplitude in either the auditory or visual modality. Female alcoholics showed reduced P300 amplitude, but only when a comorbid lifetime diagnosis of depression was present. Similar results were found using current depressed mood (Scale 2 from the MMPI). CONCLUSIONS: No differences in P300 amplitude were found between alcoholics and controls unless comorbid depression was present. Therefore, P300 amplitude reduction seen in children at high-risk for developing alcoholism seems to represent a neurodevelopmental delay that normalizes by adulthood.
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