P300 amplitude as an indicator of externalizing in adolescent males.
paper
Cited
Public
Unavailable
- Authors
- Patrick, Christopher J; Bernat, Edward M; Malone, Stephen M; Iacono, William G; Krueger, Robert F; McGue, Matt
- Year
- 2006
- Journal
- Psychophysiology
- PMID
- 16629688
- DOI
- 10.1111/j.1469-8986.2006.00376.x
- PMCID
- PMC2242347
Reduced P300 amplitude is reliably found in individuals with a personal or family history of alcohol problems. However, alcoholism is part of a broader externalizing spectrum that includes other substance use and antisocial disorders. We hypothesized that reduced P300 is an indicator of the common factor that underlies disorders within this spectrum. Community males (N=969) were assessed at age 17 in a visual oddball task. Externalizing was defined as the common factor underlying symptoms of alcohol dependence, drug dependence, nicotine dependence, conduct disorder, and adult antisocial behavior. A robust association was found between reduced P300 amplitude and the externalizing factor, and this relation accounted for links between specific externalizing disorders and P300. Our findings indicate that reduced P300 amplitude is an indicator of the broad neurobiological vulnerability that underlies disorders within the externalizing spectrum.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Disaggregation of between- and within-subject effects of internalizing symptoms on P300 amplitude during adolescence. | Santopetro NJ et al. | — | 2026 | → |
| Distinct Event-Related-Potential Biomarkers of Broad Versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum. | Patrick CJ et al. | — | 2026 | → |
| Exploring neural markers of incentive salience and real-world drinking among individuals with alcohol use disorder. | Kang D et al. | — | 2026 | → |
| Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework. | Russell NM et al. | — | 2025 | → |
| Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth. | Elliott AS et al. | — | 2025 | → |
| Posttraumatic reexperiencing and alcohol use: Mediofrontal theta as a neural mechanism for negative reinforcement. | Rawls E et al. | — | 2025 | → |
| Arousal, Gray's theory of anxiety, and the etiology of psychopathy. | Fowles DC | — | 2024 | → |
| Clarifying the place of p300 in the empirical structure of psychopathology over development. | Perkins ER et al. | — | 2024 | → |
| Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. | Brislin SJ et al. | — | 2024 | → |
| For distinguished contributions to psychophysiology: Christopher J. Patrick. | Fowles DC | — | 2024 | → |
| Influences of age and pubertal development on P300 amplitude trajectory across two years in female adolescents. | Santopetro NJ et al. | — | 2023 | → |
| Longitudinal stability and change in time-frequency measures from an oddball task during adolescence and early adulthood. | Malone SM et al. | — | 2023 | → |
| Neurobiological sensitivity to unpredictable threat and familial risk for the internalizing and externalizing spectra in adolescents. | Beatty CC et al. | — | 2023 | → |
| Posttraumatic reexperiencing and alcohol use: mediofrontal theta as a neural mechanism for negative reinforcement | Rawls E et al. | — | 2023 | — |
| Reversing food preference through multisensory exposure. | Chatterjee A et al. | — | 2023 | → |
| The P3 ERP in Relation to General Versus Specific Psychopathology in Early Childhood. | Hosch A et al. | — | 2023 | → |
| Acute sensitization of the P3 event-related potential response to beverage images and the risk for alcohol use disorder. | Cofresí RU et al. | — | 2022 | → |
| Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization. | Konzok J et al. | — | 2022 | → |
| EEG study on implicit beliefs regarding sexuality: Psychophysiological measures in relation to self-report measures. | van der Linde R et al. | — | 2022 | → |
| Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome. | Hill SY et al. | — | 2022 | → |
| Internal consistency and test-retest reliability of the P3 event-related potential (ERP) elicited by alcoholic and non-alcoholic beverage pictures. | Cofresí RU et al. | — | 2022 | → |
| Prolonged NoGo P3 latency as a possible neurobehavioral correlate of aggressive and antisocial behaviors: A Go/NoGo ERP study. | Delfin C et al. | — | 2022 | → |
| P<sub>300</sub> Wave Latency and Amplitude in Healthy Young Adults: A Normative Data. | Sorout J et al. | — | 2022 | → |
| Psychopathy: Current Knowledge and Future Directions. | Patrick CJ | — | 2022 | → |
| Signal in the noise: Altered brain activation among adolescent alcohol users detected via the analysis of intra-individual variability<sup>1</sup>. | Bauer LO et al. | — | 2022 | → |
| Event-related potential (ERP) measures of error processing as biomarkers of externalizing disorders: A narrative review. | Lutz MC et al. | — | 2021 | → |
| P300 Event-Related Potentials Mediate the Relationship Between Child Physical Abuse and Externalizing Behavior. | Cui N et al. | — | 2021 | → |
| The difference between trait disinhibition and impulsivity-and why it matters for clinical psychological science. | Joyner KJ et al. | — | 2021 | → |
| Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum. | Krueger RF et al. | — | 2021 | → |
| Violent Video Games and the P300: No Evidence to Support the Neural Desensitization Hypothesis. | Goodson S et al. | — | 2021 | → |
| A Model-Based Strategy for Interfacing Traits of the <i>DSM-5</i> AMPD With Neurobiology. | Bowyer CB et al. | — | 2020 | → |
| Electrocortical measures of performance monitoring from go/no-go and flanker tasks: Differential relations with trait dimensions of the triarchic model of psychopathy. | Ribes-Guardiola P et al. | — | 2020 | → |
| Establishing norms for error-related brain activity during the arrow Flanker task among young adults. | Imburgio MJ et al. | — | 2020 | → |
| History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency. | Puhalla AA et al. | — | 2020 | → |
| Interfacing neural constructs with the Hierarchical Taxonomy of Psychopathology: 'Why' and 'how'. | Perkins ER et al. | — | 2020 | → |
| Modeling Relations Between Triarchic Biobehavioral Traits and <i>DSM</i> Internalizing Disorder Dimensions. | Latzman RD et al. | — | 2020 | → |
| Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology . | Perkins ER et al. | — | 2020 | → |
| Neurophysiological parameters of sensory perception and cognition among different modalities of learners. | Parashar R et al. | — | 2020 | → |
| P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology. | Bernat EM et al. | — | 2020 | → |
| The neurophysiological correlates of the triarchic model of psychopathy: An approach to the basic mechanisms of threat conditioning and inhibitory control. | Paiva TO et al. | — | 2020 | → |
| Toward a multimodal measurement model for the neurobehavioral trait of affiliative capacity. | Palumbo IM et al. | — | 2020 | → |
| Using a co-twin control design to evaluate alternative trait measures as indices of liability for substance use disorders. | Joyner KJ et al. | — | 2020 | → |
| A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research. | Conway CC et al. | — | 2019 | → |
| Blunted Reward Sensitivity and Trait Disinhibition Interact to Predict Substance Use Problems. | Joyner KJ et al. | — | 2019 | → |
| Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project. | Brislin SJ et al. | — | 2019 | → |
| Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them. | Patrick CJ et al. | — | 2019 | → |
| Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses. | Martins JS et al. | — | 2019 | → |
| Interrelations Among Biologically Relevant Personality Traits, Emotion Regulation Strategies, and Clinical Symptoms. | Perkins ER et al. | — | 2019 | → |
| Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use. | Harper J et al. | — | 2019 | → |
| Antisocial behaviour and psychopathy: Uncovering the externalizing link in the P3 modulation. | Pasion R et al. | — | 2018 | → |
| Callousness and affective face processing in adults: Behavioral and brain-potential indicators. | Brislin SJ et al. | — | 2018 | → |
| Integrating Criminological and Mental Health Perspectives on Low Self-Control: A Multi-Domain Analysis. | Venables NC et al. | — | 2018 | → |
| Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders. | Venables NC et al. | — | 2017 | → |
| Gender differences in neural correlates of stress-induced anxiety. | Seo D et al. | — | 2017 | → |
| Methodological issues in the use of individual brain measures to index trait liabilities: The example of noise-probe P3. | Perkins ER et al. | — | 2017 | → |
| Neural activation patterns and connectivity in visual attention during Number and Non-number processing: An ERP study using the Ishihara pseudoisochromatic plates. | Al-Marri F et al. | — | 2017 | → |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | — | 2016 | → |
| Neurobehavioral Traits as Transdiagnostic Predictors of Clinical Problems. | Nelson LD et al. | — | 2016 | → |
| Psychoneurometric operationalization of threat sensitivity: Relations with clinical symptom and physiological response criteria. | Yancey JR et al. | — | 2016 | → |
| Recommendations for the Use of ICT in Elderly Populations with Affective Disorders. | Gros A et al. | — | 2016 | → |
| Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism. | Baskin-Sommers AR et al. | — | 2015 | → |
| Factors of psychopathy and electrocortical response to emotional pictures: Further evidence for a two-process theory. | Venables NC et al. | — | 2015 | → |
| How does reactivity to frustrative non-reward increase risk for externalizing symptoms? | Gatzke-Kopp LM et al. | — | 2015 | → |
| Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology. | Yoon HH et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward. | Vaidyanathan U et al. | — | 2015 | → |
| Triarchic Model of Psychopathy: Origins, Operationalizations, and Observed Linkages with Personality and General Psychopathology. | Patrick CJ et al. | — | 2015 | → |
| A general population twin study of conduct problems and the auditory P300 waveform. | Bertoletti E et al. | — | 2014 | → |
| Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders? | Burwell SJ et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| P3 and provoked aggressive behavior. | Fanning JR et al. | — | 2014 | → |
| Physiological correlates of psychopathy, antisocial personality disorder, habitual aggression, and violence. | Patrick CJ | — | 2014 | → |
| Protracted impairment of impulse control under an acute dose of alcohol: a time-course analysis. | Miller MA et al. | — | 2014 | → |
| Reconciling discrepant findings for P3 brain response in criminal psychopathy through reference to the concept of externalizing proneness. | Venables NC et al. | — | 2014 | → |
| The acute effects of MDMA and ethanol administration on electrophysiological correlates of performance monitoring in healthy volunteers. | Spronk DB et al. | — | 2014 | → |
| The impact of cognitive control, incentives, and working memory load on the P3 responses of externalizing prisoners. | Baskin-Sommers AR et al. | — | 2014 | → |
| Understanding the role of conscientiousness in healthy aging: where does the brain come in? | Patrick CJ | — | 2014 | → |
| A construct-network approach to bridging diagnostic and physiological domains: application to assessment of externalizing psychopathology. | Patrick CJ et al. | — | 2013 | → |
| Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. | Yoon HH et al. | — | 2013 | → |
| Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders. | Euser AS et al. | — | 2013 | → |
| Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300. | Hill SY et al. | — | 2013 | → |
| Deficient fear conditioning in psychopathy as a function of interpersonal and affective disturbances. | Veit R et al. | — | 2013 | → |
| Evidence for a Heritable Brain Basis to Deviance-Promoting Deficits in Self-Control. | Yancey JR et al. | — | 2013 | → |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | — | 2013 | → |
| Multifactorial determinants of target and novelty-evoked P300 amplitudes in children of addicted parents. | Euser AS et al. | — | 2013 | → |
| P300 amplitude reduction is associated with early-onset and late-onset pathological substance use in a prospectively studied cohort of 14-year-old adolescents. | Perlman G et al. | — | 2013 | → |
| Reduced cortical call to arms differentiates psychopathy from antisocial personality disorder. | Drislane LE et al. | — | 2013 | → |
| The association between p3 amplitude at age 11 and criminal offending at age 23. | Gao Y et al. | — | 2013 | → |
| Alterations in neural processing and psychopathology in children raised in institutions. | Slopen N et al. | — | 2012 | → |
| Dissociation between affective sharing and emotion understanding in juvenile psychopaths. | Cheng Y et al. | — | 2012 | → |
| Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders. | Criado JR et al. | — | 2012 | → |
| Expanding stress generation theory: test of a transdiagnostic model. | Conway CC et al. | — | 2012 | → |
| Is the continuity of externalizing psychopathology the same in adolescents and middle-aged adults? A test of the externalizing spectrum's developmental coherence. | Vrieze SI et al. | — | 2012 | → |
| Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects? | Gilmore CS et al. | — | 2012 | → |
| Reconceptualizing antisocial deviance in neurobehavioral terms. | Patrick CJ et al. | — | 2012 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| Validity of the Externalizing Spectrum Inventory in a criminal offender sample: relations with disinhibitory psychopathology, personality, and psychopathic features. | Venables NC et al. | — | 2012 | → |
| Clarifying relations between dispositional aggression and brain potential response: overlapping and distinct contributions of impulsivity and stress reactivity. | Venables NC et al. | — | 2011 | → |
| Delineating the construct network of the Personnel Reaction Blank: associations with externalizing tendencies and normal personality. | Blonigen DM et al. | — | 2011 | → |
| Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential. | Iacono WG et al. | — | 2011 | → |
| Externalizing psychopathology and gain-loss feedback in a simulated gambling task: dissociable components of brain response revealed by time-frequency analysis. | Bernat EM et al. | — | 2011 | → |
| N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence. | Ehlers CL et al. | — | 2011 | → |
| Operationalizing proneness to externalizing psychopathology as a multivariate psychophysiological phenotype. | Nelson LD et al. | — | 2011 | → |
| P3a amplitude predicts successful treatment program completion in substance-dependent individuals. | Anderson NE et al. | — | 2011 | → |
| Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies. | Hicks BM et al. | — | 2011 | → |
| Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. | Gilmore CS et al. | — | 2010 | → |
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | Kamarajan C et al. | — | 2010 | → |
| ERPs on a continuous performance task and self-reported psychopathic traits: P3 and CNV augmentation are associated with Fearless Dominance. | Carlson SR et al. | — | 2010 | → |
| For distinguished contributions to psychophysiology: William G. Iacono. | Miller GA | — | 2010 | → |
| Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology. | Gilmore CS et al. | — | 2010 | → |
| Specificity of P3 event-related potential reactivity to alcohol cues in individuals low in alcohol sensitivity. | Bartholow BD et al. | — | 2010 | → |
| Toward scientifically useful quantitative models of psychopathology: the importance of a comparative approach. | Krueger RF et al. | — | 2010 | → |
| Contextualizing the neurobiology of conduct disorder in an emotion dysregulation framework. | Cappadocia MC et al. | — | 2009 | → |
| Effects of induced anger in patients with antisocial personality disorder. | Lobbestael J et al. | — | 2009 | → |
| Event-related potential: An overview. | Sur S et al. | — | 2009 | → |
| Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. | Duncan CC et al. | — | 2009 | → |
| Externalizing disorders: cluster 5 of the proposed meta-structure for DSM-V and ICD-11. | Krueger RF et al. | — | 2009 | → |
| P3 event-related potential impairments in antisocial and psychopathic individuals: a meta-analysis. | Gao Y et al. | — | 2009 | → |
| The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology. | Keyes MA et al. | — | 2009 | → |
| The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. | Perlman G et al. | — | 2009 | → |
| The P300 event-related potential and its possible role as an endophenotype for studying substance use disorders: a review. | Singh SM et al. | — | 2009 | → |
| Visual P3 amplitude and self-reported psychopathic personality traits: frontal reduction is associated with self-centered impulsivity. | Carlson SR et al. | — | 2009 | → |
| A family history of psychopathology modifies the decrement in cognitive control among patients with HIV/AIDS. | Bauer LO | — | 2008 | → |
| Behavioral disinhibition and the development of early-onset addiction: common and specific influences. | Iacono WG et al. | — | 2008 | → |
| Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology. | Carlson SR et al. | — | 2008 | → |
| Psychopathic personality traits associated with abnormal selective attention and impaired cognitive control. | Sadeh N et al. | — | 2008 | → |
| Psychophysiological correlates of aggression and violence: an integrative review. | Patrick CJ | — | 2008 | → |
| The effects of childhood disruptive disorder comorbidity on P3 event-related brain potentials in preadolescents with ADHD. | Yoon HH et al. | — | 2008 | → |
| A bifactor approach to modeling the structure of the psychopathy checklist-revised. | Patrick CJ et al. | — | 2007 | → |
| Antisociality, underarousal and the validity of the Concealed Information Polygraph Test. | Verschuere B et al. | — | 2007 | → |
| Electrophysiological responses to affective stimuli in Mexican Americans: Relationship to alcohol dependence and personality traits. | Criado JR et al. | — | 2007 | → |
| Externalizing psychopathology and the error-related negativity. | Hall JR et al. | — | 2007 | → |
| Genes mediate the association between P3 amplitude and externalizing disorders. | Hicks BM et al. | — | 2007 | → |
| Validation of a rational malingering test using evoked potentials. | Zarkowski P et al. | — | 2007 | → |
| Violent offending predicts P300 amplitude. | Bernat EM et al. | — | 2007 | → |
| Association between P3 event-related brain potential amplitude and adolescent problem behavior. | Iacono WG et al. | — | 2006 | → |
| Beyond the DSM: defining endophenotypes for genetic studies of substance abuse. | Frederick JA et al. | — | 2006 | → |
| Minnesota Center for Twin and Family Research. | Iacono WG et al. | — | 2006 | → |
| Personality correlates of startle habituation. | LaRowe SD et al. | — | 2006 | → |
| Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. | Yoon HH et al. | — | 2006 | → |