Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects?
- Authors
- Gilmore, Casey S; Malone, Stephen M; Iacono, William G
- Year
- 2012
- Journal
- Psychophysiology
- PMID
- 22092064
- DOI
- 10.1111/j.1469-8986.2011.01299.x
- PMCID
- PMC3412417
P3 amplitude reduction (P3-AR) is associated with biological vulnerability to a spectrum of externalizing (EXT) disorders, such as conduct disorder, antisocial behavior, and substance use disorders. P3 amplitude, however, can be affected by the context within which it is measured, for example, by the position of the target in the sequence of stimuli during an oddball task. We hypothesized that EXT-related P3-AR may be due to attention or working memory deficits in EXT that would weaken these stimulus sequence effects. Using a community-based sample of adolescent males, we examined the relationship between P3 and EXT as a function of the number of standards preceding the target. Higher EXT was associated with significantly smaller P3 amplitude, regardless of the number of standards preceding the target. These results suggest that P3-AR in EXT does not vary as a function of stimulus sequence, further supporting P3-AR as an endophenotype for EXT disorders.
Averaged target ERPs for participants in the upper (EXT) and lower (noEXT) deciles of the distribution of EXT factor scores, collapsing over “early” occurring targets (those preceded by 1 or 2 standards) and “late” targets (those preceded by 3 or 4 standards).
LLM interpretation
This is a line graph showing averaged event-related potentials (ERPs) plotted as amplitude ($\mu$V) over time (ms). The visualization compares four conditions: "early noEXT" (solid black), "late noEXT" (dashed black), "early EXT" (solid grey), and "late EXT" (dashed grey). All conditions show a peak in amplitude between 400 and 500 ms, with the "noEXT" groups generally exhibiting higher peak amplitudes than the "EXT" groups.
| Name | Type |
|---|---|
| adult antisocial behavior | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| antisocial personality disorder | phenotype |
| conduct disorder | phenotype |
| d-prime local | phenotype |
| EEG | phenotype |
| EOG local | drug |
| EXT | phenotype |
| EXT disorder local | phenotype |
| externalizing behavior | phenotype |
| EXT factor local | phenotype |
| Grass model 12A Neurodata Acquisition System local | drug |
| Gratton, Coles, and Donchin method local | drug |
| Illicit drug abuse/dependence local | phenotype |
| illicit drug dependence | phenotype |
| illicit drugs | phenotype |
| illicit drug use | phenotype |
| MTFS | cohort |
| nicotine | drug |
| nicotine dependence | phenotype |
| P3 amplitude | phenotype |
| P3-AR local | phenotype |
| P3 latency | phenotype |
| P3-related sequence effects local | phenotype |
| parietal cortex | anatomy |
| psychopathology | phenotype |
| Pz | anatomy |
| Pz electrode | anatomy |
| reaction time | phenotype |
| substance use | phenotype |
| task performance | phenotype |
| Twin cohort | cohort |
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls. | Delfin C et al. | — | 2020 | → |
| Context Dependence Signature, Stimulus Properties and Stimulus Probability as Predictors of ERP Amplitude Variability. | Mugruza-Vassallo C et al. | — | 2019 | → |
| Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level: A Pilot Study. | Ventura-Bort C et al. | — | 2018 | → |
| Stimulus sequence context differentially modulates inhibition-related theta and delta band activity in a go/no-go task. | Harper J et al. | — | 2016 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| Genetic psychophysiology: advances, problems, and future directions. | Anokhin AP | — | 2014 | → |
| Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. | Yoon HH et al. | — | 2013 | → |