Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.

paper Primary Public

Authors: Chorlian, David B; Rangaswamy, Madhavi; Manz, Niklas; Wang, Jen-Chyong; Dick, Danielle; Almasy, Laura; Bauer, Lance; Bucholz, Kathleen; Foroud, Tatiana; Hesselbrock, Victor; Kang, Sun J; Kramer, John; Kuperman, Sam; Nurnberger, John; Rice, John; Schuckit, Marc; Tischfield, Jay; Edenberg, Howard J; Goate, Alison; Bierut, Laura; Porjesz, Bernice
Year: 2013
Journal: Behavior genetics
PMID: 23963516
DOI: 10.1007/s10519-013-9604-z
PMCID: PMC4110722

#	Section	Preview
0	1 Introduction	That genetic factors have an age-specific influence on the onset of alcohol dependence is suggested…
1	1 Introduction	Studies of adolescent brain development point to neurophysiological factors that could enhance the…
2	1 Introduction	Alcohol dependence and risk for alcoholism in both adults and adolescents is associated with reduced…
3	1 Introduction	Alcohol dependence in adults was found to be associated with a number of SNPs in the cholinergic M2…
4	1 Introduction	CHRM2 gene (Dick et al., 2008). Additionally, there is variation in the genetic factors associated…
5	1 Introduction	In order to investigate the age specificity of the genetic and endophenotypic factors noted above on…
6	1 Introduction	Discrete time survival analysis (DTSA) (Singer and Willett, 1993; Willett and Singer, 1993;…
7	2 Methods and Materials — 2.1 Subjects	Data were analyzed in a cross sectional sample (N = 2938) of subjects who were assessed at least…
8	2 Methods and Materials — 2.2 Clinical variables	Diagnostic measures for outcomes were taken from direct interviews using the Semi Structured…
9	2 Methods and Materials — 2.2 Clinical variables	Illicit drug use was defined as the use of any of heroin, cocaine, barbiturates, or amphetamines…
10	2 Methods and Materials — 2.3 Genotyping	Genotyping was performed using Illumina’s GoldenGate assays (Illumina, San Diego, CA, USA) at the…
11	2 Methods and Materials — 2.4 Electrophysiology	A substantial literature indicates that alcohol dependence and risk for alcoholism are associated…
12	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	Since the principal objective is to determine whether there are age-varying effects of the…
13	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	functional form of the model can be set to determine age-specific effects and/or age-independent…
14	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	Each DTSA model had the following structure: The outcomes, or dependent variables were either…
15	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	ERO power (delta 1–3 Hz) from one of the leads, family type (multiplex alcohol family or community…
16	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	DTSA results were calculated for the entire sample. Our fourth item for investigation, whether the…
17	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	cannabis as illicit drug use. Since more than half the sample are characterized as regular users of…
18	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	drug use subsample, there were too few alcohol dependent subjects with no illicit drug use to…
19	2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods	Since regular alcohol use is a necessary condition of alcohol dependence, it could not be used as a…

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In this knowledge base

Title	Year	PMID
Genetic correlates of the development of theta event related oscillations in adolescents and young adults.	2017	27847216
Advances in Electrophysiological Research.	2015	26259089
A Long-Term Longitudinal Examination of the Effect of Early Onset of Alcohol and Drug Use on Later Alcohol Abuse.	2015	25671782
Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task.	2015	26388585

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