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Chunk #19 — 2 Methods and Materials — 2.5 Methodology for age-specific analysis — 2.5.1 DTSA methods

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Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.
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Since regular alcohol use is a necessary condition of alcohol dependence, it could not be used as a covariate in the DTSA calculation of the onset of alcohol dependence. In order to investigate the duration of the transition from regular alcohol use to alcohol dependence as a function of the age of onset of alcohol dependence, the third item for investigation, logistic regression analyses of the onset of alcohol dependence as the outcome in each of the age ranges, restricted to the sample of those who are regular users of alcohol within that age range, were carried out. All covariates used in the DTSA calculations were used with duration of drinking as an additional covariate. (Duration of drinking was modeled both as a linear effect only and a linear and quadratic effect.) Although those who become alcohol dependent are removed from the sample at each age range, this is not a survival analysis method because new regular users of alcohol are added to the sample at each age range. However, the results of these tests can be compared to the