Heterogeneity in the inheritance of alcoholism. A study of male and female twins.
paper
Cited
Public
Unavailable
- Authors
- Pickens, R W; Svikis, D S; McGue, M; Lykken, D T; Heston, L L; Clayton, P J
- Year
- 1991
- Journal
- Archives of general psychiatry
- PMID
- 1984758
- DOI
- 10.1001/archpsyc.1991.01810250021002
Genetic influence on risk for alcoholism was examined in a US treatment sample of 50 monozygotic (MZ) and 64 dizygotic (DZ) male and 31 MZ and 24 DZ female same-sex twin pairs. For the DSM-III composite diagnosis of Alcohol Abuse and/or Dependence, statistically significant MZ/DZ differences in concordance were found with male, but not female, twins. For specific diagnoses, MZ/DZ differences were found in male subjects for both Alcohol Abuse and Alcohol Dependence, while MZ/DZ differences in female subjects were found only for Alcohol Dependence. The male MZ/DZ concordance difference for composite diagnosis but not for Alcohol Dependence could be accounted for statistically by differences in age of onset between MZ and DZ probands. As with alcohol, differences in MZ/DZ concordance were found for DSM-III composite diagnoses of Other Substance Abuse and/or Dependence with male, but not female, twins. Using Epidemiological Catchment Area data to estimate the population base rates of both alcohol and other substance use disorders allowed for heritability analyses that showed genetic factors to have only a modest influence on overall risk in both sexes (heritability estimates of approximately 0.35 for male subjects and 0.24 for female subjects). However, evidence for heterogeneity in the pattern of inheritance was also found, suggesting forms of alcoholism that may be moderately to highly heritable.
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| No allelic association of an exon 13 polymorphism of the GsΞ± gene to alcohol and/or drug dependence. | Kranzler HR et al. | β | 1997 | β |
| Phosphorus-31 magnetic resonance brain spectroscopy of children at risk for a substance use disorder: preliminary results. | Moss HB et al. | β | 1997 | β |
| Prodynorphin allelic distribution in Scandinavian chronic alcoholics. | Geijer T et al. | β | 1997 | β |
| Religion, psychopathology, and substance use and abuse; a multimeasure, genetic-epidemiologic study. | Kendler KS et al. | β | 1997 | β |
| The D2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functions in children. | Berman SM et al. | β | 1997 | β |
| Twin closeness and co-twin risk for substance use disorders: assessing the impact of the equal environment assumption. | LaBuda MC et al. | β | 1997 | β |
| Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandinavian chronic alcoholics. | Geijer T et al. | β | 1997 | β |
| Alcoholism and the dopaminergic system: a review. | Noble EP | β | 1996 | β |
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| An adoption study of DSM-IIIR alcohol and drug dependence severity. | Yates WR et al. | β | 1996 | β |
| Childhood parental loss and alcoholism in women: a causal analysis using a twin-family design. | Kendler KS et al. | β | 1996 | β |
| Comorbidity of Alcoholism and Anxiety Disorders: The Role of Family Studies. | Merikangas KR et al. | β | 1996 | β |
| Conference summary: Consensus Conference on Alcohol Dependence and the Role of Pharmacotherapy in its Treatment. | Chick J et al. | β | 1996 | β |
| D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. | Persico AM et al. | β | 1996 | β |
| Effect of diazepam on plasma gamma-aminobutyric acid in sons of alcoholic fathers. | Cowley DS et al. | β | 1996 | β |
| Female PCP-using jail detainees: proneness to violence and gender differences. | Fishbein DH | β | 1996 | β |
| Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. | Tsuang MT et al. | β | 1996 | β |
| Genetic predisposition to organ-specific endpoints of alcoholism. | Reed T et al. | β | 1996 | β |
| Indicators of genetic and environmental influence in alcohol-dependent individuals. | Johnson EO et al. | β | 1996 | β |
| Indicators of genetic and environmental influences in drug abusing individuals. | Johnson EO et al. | β | 1996 | β |
| Mating assortment and the liability to substance abuse. | Vanyukov MM et al. | β | 1996 | β |
| No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. | Lu RB et al. | β | 1996 | β |
| Potential barriers to parent monitoring: social disadvantage, marital status, and maternal psychiatric disorder. | Chilcoat HD et al. | β | 1996 | β |
| Quantitative trait locus gene mapping: a new method for locating alcohol response genes. | Crabbe JC | β | 1996 | β |
| Substance abuse, comorbidity, and sensation seeking: gender differences. | Scourfield J et al. | β | 1996 | β |
| Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. | Johnson EO et al. | β | 1996 | β |
| The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. | Blum K et al. | β | 1996 | β |
| The disease called addiction: emerging evidence in a 200-year debate. | Meyer RE | β | 1996 | β |
| Type I and Type II Alcoholism: An Update. | Cloninger CR et al. | β | 1996 | β |
| Autonomic reactivity and alcohol-induced dampening in men at risk for alcoholism and men at risk for hypertension. | Conrod PJ et al. | β | 1995 | β |
| Common genetic mechanisms in alcohol, drug, and mental disorder comorbidity. | Pickens RW et al. | β | 1995 | β |
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| Inheritance of Alcohol Abuse: Cross-Fitting Analysis of Adopted Men. | Heath AC | β | 1995 | β |
| Neurobiological and Clinical Markers for a Severe Form of Alcoholism in Women. | Hill SY | β | 1995 | β |
| Prepubertal sons of substance abusers: influences of parental and familial substance abuse on behavioral disposition, IQ, and school achievement. | Moss HB et al. | β | 1995 | β |
| Reduced visuospatial performance in children with the D2 dopamine receptor A1 allele. | Berman SM et al. | β | 1995 | β |
| Sex differences and the effects of tail pinch on ethanol drinking in Maudsley rats. | Adams N | β | 1995 | β |
| Acute alcohol exposure markedly influences male fertility and fetal outcome in the male rat. | Cicero TJ et al. | β | 1994 | β |
| Adrenocorticotropin responses following administration of ethanol and ovine corticotropin-releasing hormone in the sons of alcoholics and control subjects. | Waltman C et al. | β | 1994 | β |
| Alpha-1- and 2-adrenoceptor subsensitivity in siblings of opioid addicts with personality disorders and depression. | Gerra G et al. | β | 1994 | β |
| Assortment for the liability to substance abuse and personality traits. | Vanyukov MM et al. | β | 1994 | β |
| A twin-family study of alcoholism in women. | Kendler KS et al. | β | 1994 | β |
| Developmental evidence for at least two alcoholisms. I. Biopsychosocial variation among pathways into symptomatic difficulty. | Zucker RA et al. | β | 1994 | β |
| Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism. | Wand GS et al. | β | 1994 | β |
| Effects of Paternal Exposure to Alcohol on Offspring Development. | Cicero TJ | β | 1994 | β |
| Environmental differences in young men with and without a family history of alcoholism. | Searles JS et al. | β | 1994 | β |
| Evidence that the type 1/type 2 dichotomy in alcoholism must be re-examined. | Vaillant GE | β | 1994 | β |
| Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects. | Cowley DS et al. | β | 1994 | β |
| Familial resemblance for psychoactive substance use disorders: behavioral profile of high risk boys. | Moss HB et al. | β | 1994 | β |
| Family history of alcoholism and childhood adversity: joint effects on alcohol consumption and dependence. | Hill EM et al. | β | 1994 | β |
| Genetic aspects and risk factors in alcoholism and alcoholic liver disease. | Lumeng L et al. | β | 1994 | β |
| Genetic Aspects of Alcohol Use and Alcoholism in Women. | Svikis DS et al. | β | 1994 | β |
| Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. I. Drug abuse. | Comings DE | β | 1994 | β |
| Genetic influences on alcohol consumption patterns and problem drinking: results from the Australian NH&MRC twin panel follow-up survey. | Heath AC et al. | β | 1994 | β |
| Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. | Wang JB et al. | β | 1994 | β |
| Human neuroscience at National Institute on Drug Abuse: implications for genetics research. | Gordon HW | β | 1994 | β |
| Interpersonal variables in the prediction of alcoholism among adoptees: evidence for gene-environment interactions. | Cutrona CE et al. | β | 1994 | β |
| Serotonin and alcohol intake, abuse, and dependence: clinical evidence. | LeMarquand D et al. | β | 1994 | β |
| The power of the classical twin study to resolve variation in threshold traits. | Neale MC et al. | β | 1994 | β |
| A hypothesis for a common neurochemical basis for alcohol and drug disorders. | Miller NS et al. | β | 1993 | β |
| Allelic association of the D2 dopamine receptor gene with cocaine dependence. | Noble EP et al. | β | 1993 | β |
| A neurochemical basis for alcohol and other drug addiction. | Miller NS et al. | β | 1993 | β |
| An experimental approach to understanding the genetic and neurobiological basis of alcoholism. | Li TK et al. | β | 1993 | β |
| Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. | Arinami T et al. | β | 1993 | β |
| A strategy for assembling samples of adult twin pairs in the United States. | Goldberg J et al. | β | 1993 | β |
| A systematic assessment of the comorbidity of DSM-III-R personality disorders in alcoholic outpatients. | Nurnberg HG et al. | β | 1993 | β |
| Benno Pollak Lecture 1992. Alcohol dependence--an illness with a treatment? | Chick J | β | 1993 | β |
| D2 dopamine receptor gene and alcoholism. | AmadΓ©o S et al. | β | 1993 | β |
| Differences in morphine reinforcement property in two inbred rat strains: associations with cortical receptors, behavioral activity, analgesia and the cataleptic effects of morphine. | Sudakov SK et al. | β | 1993 | β |
| Event-related potentials in women at risk for alcoholism. | Hill SY et al. | β | 1993 | β |
| Genes, environment, and addictive behavior: etiology of individual differences and extreme cases. | Rende R | β | 1993 | β |
| Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. | Blum K et al. | β | 1993 | β |
| Substance abuse vulnerability and D2 receptor genes. | Uhl G et al. | β | 1993 | β |
| Substance misuse and comorbid psychopathology in a high-risk group: a study of siblings of cocaine misusers. | Luthar SS et al. | β | 1993 | β |
| The D2 dopamine receptor gene: a review of association studies in alcoholism. | Noble EP | β | 1993 | β |
| The influence of perceived social support on the relationship between family history of alcoholism and drinking behaviors. | Ohannessian CM et al. | β | 1993 | β |
| A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs. | Vandenbergh DJ et al. | β | 1992 | β |
| Alcoholism and substance abuse among selected southern Cheyenne Indians. | Brown GL et al. | β | 1992 | β |
| Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. | Vandenbergh DJ et al. | β | 1992 | β |
| Risk for affective disorder and alcohol and other drug abuse in the relatives of affectively ill adoptees. | Ingraham LJ et al. | β | 1992 | β |
| Sex differences in pattern of drinking. | Lancaster FE et al. | β | 1992 | β |
| Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. | Blum K et al. | β | 1991 | β |
| Evidence for genetic mediation of alcoholism in women. | Hill SY et al. | β | 1991 | β |
| The familial transmission of alcoholism. | Marshall EJ et al. | β | 1991 | β |
| Information processing, neuropsychological function, and the inherited predisposition to alcoholism. | Peterson JB et al. | β | 1990 | β |