Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.

paper Primary Public

Authors: Dick, Danielle M; Meyers, Jacquelyn; Aliev, Fazil; Nurnberger, John; Kramer, John; Kuperman, Sam; Porjesz, Bernice; Tischfield, Jay; Edenberg, Howard J; Foroud, Tatiana; Schuckit, Marc; Goate, Alison; Hesselbrock, Victor; Bierut, Laura
Year: 2010
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
PMID: 20468071
DOI: 10.1002/ajmg.b.31089
PMCID: PMC3597340

#	Section	Preview
0	INTRODUCTION	Twin studies provide strong evidence of shared genetic liability across a number of different…
1	INTRODUCTION	often vary on a number of important dimensions, including age of onset, course of illness, and the…
2	INTRODUCTION	Data from the Collaborative Study on the Genetics of Alcoholism (COGA) suggest that chromosome…
3	INTRODUCTION	was replicated in the Irish Affected Sib Pair Study for Alcohol Dependence [Kendler et al., 2006a].…
4	INTRODUCTION	et al., 2003] have also been reported on chromosome 2 in independent samples. Although linkage to a…
5	INTRODUCTION	The phenotypes of alcohol dependence, conduct disorder, and suicide attempts, which show linkage on…
6	INTRODUCTION	2005; Enoch, 2008; Soyka et al., 2008] is associated with CD symptoms and externalizing behavior in…
7	INTRODUCTION	associated with externalizing behaviors, including antisocial behavior and alcohol-related…
8	INTRODUCTION	Additional follow-up of the linkage signals observed across the three phenotypes in COGA suggested…
9	INTRODUCTION	Here we report a series of linkage and association analyses in the COGA sample to follow up the…
10	METHODS — Sample	COGA is a multi-site project, with the goal of identifying genes contributing to alcoholism and…
11	METHODS — Sample	DSM-IIIR alcohol dependence diagnosis [Diagnostic and Statistical Manual of Mental Disorders: IIIR,…
12	METHODS — Molecular Methods and Analysis — Linkage samples and analyses	A microsatellite linkage scan was conducted on a sample of 2,282 individuals from 262 families…
13	METHODS — Molecular Methods and Analysis — Linkage samples and analyses	In addition to the primary COGA linkage sample, a subset of the COGA linkage families were selected…
14	METHODS — Molecular Methods and Analysis — Linkage samples and analyses	Non-parametric, multipoint methods of linkage analysis for affected sibling pairs were employed,…
15	METHODS — Molecular Methods and Analysis — Association analyses	SNP data were available across chromosome 2, generated as part of the genome-wide association study…
16	METHODS — Molecular Methods and Analysis — Association analyses	Because all cases genotyped in the GWAS sample were affected with AD, the association analyses…
17	METHODS — Molecular Methods and Analysis — Association analyses	the AD with either CD or SUI phenotype, 218 (42.7%) had a reported suicide attempt and 367 (71.8%)…
18	METHODS — Molecular Methods and Analysis — Association analyses	The program Plink [Purcell et al., 2007] (http://pngu.mgh.harvard.edu/purcell/plink/) was used to…
19	METHODS — Molecular Methods and Analysis — Association analyses	Permutation tests were conducted for all genes yielding at least 1 P-value <0.001, as well as for…

Name	Type
ACN9	gene
adult antisocial behavior	phenotype
AD with CD local	phenotype
AD with CD or SUI local	phenotype
African American	cohort
aggression	phenotype
alcohol	phenotype
alcohol dependence	phenotype
Alcohol Dependence Symptoms	phenotype
alcoholism	phenotype
Alcohol-related aggression	phenotype
alcohol withdrawal	phenotype
Alzheimer's disease	phenotype
antisocial personality disorder	phenotype
association sample local	cohort
behavioral disinhibition	phenotype
behavioral under-control	phenotype
bipolar disorder	phenotype
broader AD or CD or SUI phenotype local	phenotype
case–control sample local	cohort
Caucasian	cohort
CD	phenotype
Centromeric region of chromosome 2 local	drug
childhood conduct disorder	phenotype
chromosome 2 local	drug
Chromosome 2 local	drug
Chromosome 2p local	drug
Chromosome 2q local	drug
COGA adult sample local	cohort
COGA family sample local	cohort
COGA sample	cohort
Collaborative Study on the Genetics of Alcoholism (COGA)	cohort
conduct disorder	phenotype
controls	cohort
D2S379 local	variant
disinhibitory behavior	phenotype
Disinhibitory disorders	phenotype
drug dependence	phenotype
DSM-IV alcohol dependence	phenotype
Early-onset major depression local	phenotype
European ancestry	cohort
externalizing attempts local	phenotype
externalizing behavior	phenotype
externalizing disorders	phenotype
Externalizing genetic factor local	gene
families	cohort
GABRA2	gene
GAW14 local	cohort
generalized anxiety disorder	phenotype
genes	gene
Genetic Analysis Workshop 14 local	cohort
genetic factors	cohort
habitual smoking	phenotype
Habitual smoking and alcohol dependence local	phenotype
HapMap reference samples local	cohort
high risk COGA family-based sample local	cohort
illicit drug dependence	phenotype
illicit drugs	phenotype
Illumina panel local	drug
impulsivity	phenotype
Inpatient substance abuse patients local	cohort
internalizing-based behavior local	phenotype
Internalizing genetic factor local	gene
Irish Affected Sib Pair Study for Alcohol Dependence local	cohort
major depressive disorder	phenotype
mesolimbic dopamine system	drug
microsatellite	variant
neurotensin	drug
NTSR2 local	gene
phenotype	phenotype
phobic anxiety	phenotype
psychostimulants	drug
smoking	phenotype
SNP	cohort
substance use	phenotype
SUI	phenotype
suicide	phenotype
Twin cohort	cohort
Virginia Twin Registry	cohort

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In this knowledge base

Title	Year	PMID
Genetic influences on conduct disorder.	2018	27350097
Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells.	2014	24751885
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.	2014	24166409
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.	2011	21529783

External

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