Because all cases genotyped in the GWAS sample were affected with AD, the association analyses focused on the combined AD with CD or SUI phenotype. Individuals were considered affected if they met criteria for AD and either CD or SUI, in addition to the primary AD case phenotype: 511 individuals (of the original 1,205 cases) met criteria for the AD with CD or SUI phenotype. A subset of individuals in the COGA GWAS sample (N = 321) were not assessed for suicide attempts; accordingly, when unaffected by conduct disorder, their combined “case” status was unknown, so 231 individuals were excluded from analyses for this reason. Additionally, 40 controls were excluded from analyses because of previous suicide attempts (N = 18) or the presence of a conduct disorder diagnosis (N = 22). Of the 511 AD cases who met criteria for the AD with either CD or SUI phenotype, 218 (42.7%) had a reported suicide attempt and 367 (71.8%) met criteria for conduct disorder; 74 individuals (14.5%) met criteria for both. 70.8% were male and 29.2% female. The age range was
