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Chunk #15 — METHODS — Molecular Methods and Analysis — Association analyses

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Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
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SNP data were available across chromosome 2, generated as part of the genome-wide association study (GWAS) of the COGA sample by the Center for Inherited Disease Research, using the Illumina HumanHap1M BeadChip platform, and are available through dbGaP. After all data cleaning, genome wide data were available for 1905 individuals [Edenberg et al., 2010]. All 1,205 cases met criteria for DSM-IV Alcohol Dependence, as assessed by the SSAGA, and all 700 controls were screened against Alcohol Dependence and related substance use disorders. Three hundred twenty-four of the cases were drawn from families included in the primary COGA linkage sample. Males were overrepresented in the cases. Additional details about the COGA GWAS sample are available in Edenberg et al. [2010].