Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample.
paper
Primary
Public
Unavailable
- Authors
- Agrawal, Arpana; Hinrichs, Anthony L; Dunn, Gerald; Bertelsen, Sarah; Dick, Danielle M; Saccone, Scott F; Saccone, Nancy L; Grucza, Richard A; Wang, Jen C; Cloninger, C Robert; Edenberg, Howard J; Foroud, Tatiana; Hesselbrock, Victor; Kramer, John; Bucholz, Kathleen K; Kuperman, Samuel; Nurnberger, John I; Porjesz, Bernice; Schuckit, Marc A; Goate, Alison M; Bierut, Laura J
- Year
- 2008
- Journal
- Drug and alcohol dependence
- PMID
- 17942244
- DOI
- 10.1016/j.drugalcdep.2007.08.015
- PMCID
- PMC2266629
Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol dependence criteria, cannabis dependence criteria and dependence criteria across any illicit drug (including cannabis) individually and in combination as an average score across alcohol and illicit drug dependence criteria. For alcohol dependence, LOD scores exceeding 2.0 were noted on chromosome 1 (2.0 at 213 cM), 2 (3.4 at 234 cM) and 10 (3.7 at 60 cM). For cannabis dependence, a maximum LOD of 1.9 was noted at 95 cM on chromosome 14. For any illicit drug dependence, LODs of 2.0 and 2.4 were observed on chromosome 10 (116 cM) and 13 (64 cM) respectively. Finally, the combined alcohol and/or drug dependence symptoms yielded LODs >2.0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | — | 2023 | → |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | — | 2022 | → |
| The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond. | Verweij KJH et al. | — | 2022 | → |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | — | 2021 | → |
| The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers. | Mateu C et al. | — | 2021 | → |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | — | 2020 | → |
| Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. | Datta U et al. | — | 2020 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| Endotoxin at the Maternal-Fetal Interface in a Resource-Constrained Setting: Risk Factors and Associated Birth Outcomes. | McDonald EA et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Randomized controlled pilot trial of supportive text messaging for alcohol use disorder patients. | Agyapong VIO et al. | — | 2018 | → |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | — | 2017 | → |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | — | 2017 | → |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | — | 2016 | → |
| Genome-wide significant loci for addiction and anxiety. | Hodgson K et al. | — | 2016 | → |
| Pharmacological approaches to the management of binge eating disorder. | Brownley KA et al. | — | 2015 | → |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | — | 2014 | → |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | — | 2014 | → |
| Polymorphisms of genes in neurotransmitter systems were associated with alcohol use disorders in a Tibetan population. | Xu Y et al. | — | 2013 | → |
| The genetics of alcohol dependence. | Rietschel M et al. | — | 2013 | → |
| CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity. | Onaivi ES et al. | — | 2012 | → |
| Effects of alcohol dependence on cortical thickness as determined by magnetic resonance imaging. | Momenan R et al. | — | 2012 | → |
| Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. | Han S et al. | — | 2012 | → |
| Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood. | van Beek JH et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. | Gallego X et al. | — | 2012 | → |
| A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. | Wang KS et al. | — | 2011 | → |
| Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. | Lydall GJ et al. | — | 2011 | → |
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | Zlojutro M et al. | — | 2011 | → |
| Person-centered Therapeutics. | Cloninger CR et al. | — | 2011 | → |
| A Person-Centered Approach to Clinical Practice. | Wong KM et al. | — | 2010 | → |
| Challenging the "inoffensiveness" of regular cannabis use by its associations with other current risky substance use--a census of 20-year-old Swiss men. | Gmel G et al. | — | 2010 | → |
| Confirmation and generalization of an alcohol-dependence locus on chromosome 10q. | Panhuysen CI et al. | — | 2010 | → |
| Consilience of rodent and human phenotypes relevant for alcohol dependence. | Crabbe JC | — | 2010 | → |
| EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study. | Ehlers CL et al. | — | 2010 | → |
| Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | Dick DM et al. | — | 2010 | → |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | — | 2010 | → |
| High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. | Philip VM et al. | — | 2010 | → |
| Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study. | Ehlers CL et al. | — | 2010 | → |
| Linkage analysis of alcohol dependence symptoms in the community. | Hansell NK et al. | — | 2010 | → |
| Candidate genes for cannabis use disorders: findings, challenges and directions. | Agrawal A et al. | — | 2009 | → |
| Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? | Hansell NK et al. | — | 2009 | → |
| Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. | Gelernter J et al. | — | 2009 | → |
| Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts. | Agrawal A et al. | — | 2009 | → |
| Differential role of serotonergic polymorphisms in alcohol and heroin dependence. | Saiz PA et al. | — | 2009 | → |
| Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. | Agrawal A et al. | — | 2009 | → |
| Genetical genomic determinants of alcohol consumption in rats and humans. | Tabakoff B et al. | — | 2009 | → |
| Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. | Ehlers CL et al. | — | 2009 | → |
| Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. | Saccone NL et al. | — | 2009 | → |
| Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study. | Saiz PA et al. | — | 2009 | → |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | — | 2008 | → |
| Genomic insights into acute alcohol tolerance. | Hu W et al. | — | 2008 | → |
| Molecular genetics of alcohol dependence and related endophenotypes. | Strat YL et al. | — | 2008 | → |
| Ordered subsets linkage analysis of antisocial behavior in substance use disorder among participants in the Collaborative Study on the Genetics of Alcoholism. | Jacobson KC et al. | — | 2008 | → |
| Substance dependence low-density whole genome association study in two distinct American populations. | Yu Y et al. | — | 2008 | → |
| The role of selected factors in the development and consequences of alcohol dependence. | Gilbertson R et al. | — | 2008 | → |