A genome-wide screen for genes influencing conduct disorder.
paper
Primary
Public
Unavailable
- Authors
- Dick, D M; Li, T-K; Edenberg, H J; Hesselbrock, V; Kramer, J; Kuperman, S; Porjesz, B; Bucholz, K; Goate, A; Nurnberger, J; Foroud, T
- Year
- 2004
- Journal
- Molecular psychiatry
- PMID
- 14699444
- DOI
- 10.1038/sj.mp.4001368
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetics and epigenetics of human aggression. | Odintsova VV et al. | — | 2023 | → |
| Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum. | Krueger RF et al. | — | 2021 | → |
| Association of PPM1G methylation with risk-taking in alcohol use disorder. | Park CI et al. | — | 2020 | → |
| History of suicidality and alcohol craving trajectories during inpatient treatment for alcohol use disorder. | Janakiraman R et al. | — | 2020 | → |
| Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool. | Odintsova VV et al. | — | 2019 | → |
| Neural oscillatory dynamics of inhibitory control in young adult binge drinkers. | Holcomb LA et al. | — | 2019 | → |
| Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?" | Dick DM | — | 2018 | → |
| Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium. | Freitag CM et al. | — | 2018 | → |
| Genetic influences on conduct disorder. | Salvatore JE et al. | — | 2018 | → |
| Joint Effects of Age, Period, and Cohort on Conduct Problems Among American Adolescents From 1991 Through 2015. | Keyes KM et al. | — | 2018 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Dimensionality and Genetic Correlates of Problem Behavior in Low-Income African American Adolescents. | Latendresse SJ et al. | — | 2017 | → |
| GABA<sub>A</sub> receptor subtype involvement in addictive behaviour. | Stephens DN et al. | — | 2017 | → |
| A genome-wide approach to children's aggressive behavior: The EAGLE consortium. | Pappa I et al. | — | 2016 | → |
| Beyond main effects of gene-sets: harsh parenting moderates the association between a dopamine gene-set and child externalizing behavior. | Windhorst DA et al. | — | 2016 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| Genetic and environmental influences on nutrient intake. | Liu J et al. | — | 2013 | → |
| Genetics of alcohol dependence and social work research: do they mix? | Hesselbrock MN et al. | — | 2013 | → |
| Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for acute ethanol sensitivity in Drosophila. | Chen J et al. | — | 2013 | → |
| Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders. | Criado JR et al. | — | 2012 | → |
| Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. | Jian XQ et al. | — | 2011 | → |
| Callous and unemotional traits and social cognitive processes in a sample of community-based aggressive youth. | Lorber CM et al. | — | 2011 | → |
| Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder. | Lydall GJ et al. | — | 2011 | → |
| Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. | Duka T et al. | — | 2011 | → |
| Genome-wide association study of conduct disorder symptomatology. | Dick DM et al. | — | 2011 | → |
| Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study. | Gizer IR et al. | — | 2011 | → |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | — | 2010 | → |
| Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature. | Gunter TD et al. | — | 2010 | → |
| Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | Dick DM et al. | — | 2010 | → |
| In search of genes associated with risk for psychopathic tendencies in children: a two-stage genome-wide association study of pooled DNA. | Viding E et al. | — | 2010 | → |
| Linkage analysis of alcohol dependence symptoms in the community. | Hansell NK et al. | — | 2010 | → |
| NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. | Yan TC et al. | — | 2010 | → |
| Obesity, smoking, and frontal brain dysfunction. | Bauer L et al. | — | 2010 | → |
| Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR). | Sakai JT et al. | — | 2010 | → |
| Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community. | Ehlers CL et al. | — | 2009 | → |
| The relation of ADHD and violent aggression: What can we learn from epidemiological and genetic studies? | Retz W et al. | — | 2009 | → |
| A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. | Ghosh S et al. | — | 2008 | → |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | — | 2008 | → |
| Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. | Anney RJ et al. | — | 2008 | → |
| Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. | Ehlers CL et al. | — | 2008 | → |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | — | 2008 | → |
| Multiple-domain predictors of problematic alcohol use in young adulthood. | Kramer JR et al. | — | 2008 | → |
| Ordered subsets linkage analysis of antisocial behavior in substance use disorder among participants in the Collaborative Study on the Genetics of Alcoholism. | Jacobson KC et al. | — | 2008 | → |
| Research review: DSM-V conduct disorder: research needs for an evidence base. | Moffitt TE et al. | — | 2008 | → |
| Attention-deficit/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility loci. | Jain M et al. | — | 2007 | → |
| Common genetic risk of major depression and nicotine dependence: the contribution of antisocial traits in a United States veteran male twin cohort. | Fu Q et al. | — | 2007 | → |
| A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. | Kendler KS et al. | — | 2006 | → |
| Familial risks, conduct disorder and violence: A Finnish study of 278 adolescent boys and girls. | Ilomäki E et al. | — | 2006 | → |
| Genetics and alcoholism: how close are we to potential clinical applications? | Quickfall J et al. | — | 2006 | → |
| The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. | Dick DM et al. | — | 2006 | → |
| The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. | Dick DM et al. | — | 2006 | → |
| Heritability of substance dependence in a native American population. | Wilhelmsen KC et al. | — | 2005 | → |
| Recent developments in the genetics of alcohol-related phenotypes. | Hesselbrock V et al. | — | 2005 | → |
| The natural history of adolescent alcohol use disorders. | Clark DB | — | 2004 | → |
| The search for genetic risk factors associated with suicidal behavior. | Hesselbrock V et al. | — | 2004 | → |