The Collaborative Study on the Genetics of Alcoholism.
paper
Primary
Public
Unavailable
- Year
- 1995
- Journal
- Alcohol health and research world
- PMID
- 31798102
- PMCID
- PMC6875768
In 1989 the National Institute on Alcohol Abuse and Alcoholism initiated the Collaborative Study on the Genetics of Alcoholism (COGA), a large-scale, multidisciplinary research program to investigate the genetic components of the susceptibility to alcohol abuse and dependence. COGA involves six research centers located across the United States. The following articles by leading COGA investigators provide an overview of the design of this study and its components and of the challenges inherent to an endeavor of this scope. The authors also present some of the results obtained through COGA to date. Although sometimes still preliminary in nature, these findings reflect COGA's potential for greatly improving our knowledge of the complex disorder of alcoholism.
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| Rice, JP et al., Genetic Epidemiology, 1995, TDT with covariates and genomic screens with Mod Scores: Their behavior on simulated data | 8787990 | 10.1002/gepi.1370120623 | Primary |
In this knowledge base
External
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|---|---|---|---|---|
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| Genome-wide iterative fine-mapping for non-Gaussian phenotypes. | Xu S et al. | β | 2025 | β |
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| A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency. | Thomas NS et al. | β | 2024 | β |
| Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. | Brislin SJ et al. | β | 2024 | β |
| Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors. | Savage JE et al. | β | 2024 | β |
| Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults. | Su J et al. | β | 2023 | β |
| Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder. | Kuo SI et al. | β | 2023 | β |
| Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts. | Colbert SMC et al. | β | 2023 | β |
| Genetic nurture effects for alcohol use disorder. | Thomas NS et al. | β | 2023 | β |
| Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. | Williams CM et al. | β | 2023 | β |
| Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features. | Kamarajan C et al. | β | 2023 | β |
| RNA alternative splicing impacts the risk for alcohol use disorder | Liu Y et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | β | 2023 | β |
| BICOSS: Bayesian iterative conditional stochastic search for GWAS. | Williams J et al. | β | 2022 | β |
| Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts. | Barr PB et al. | β | 2022 | β |
| Examining social genetic effects on educational attainment via parental educational attainment, income, and parenting. | Su J et al. | β | 2022 | β |
| Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. | Mallard TT et al. | β | 2022 | β |
| Principal Component Analysis Reduces Collider Bias in Polygenic Score Effect Size Estimation. | Thomas NS et al. | β | 2022 | β |
| RNA biomarkers for alcohol use disorder. | Ferguson LB et al. | β | 2022 | β |
| The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse. | Stephenson M et al. | β | 2022 | β |
| The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance. | Kuo SI et al. | β | 2022 | β |
| Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. | Tielbeek JJ et al. | β | 2022 | β |
| Associations between Suicidal Thoughts and Behaviors and Genetic Liability for Cognitive Performance, Depression, and Risk-Taking in a High-Risk Sample. | Johnson EC et al. | β | 2021 | β |
| Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. | Karlsson LinnΓ©r R et al. | β | 2021 | β |
| Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples. | Johnson EC et al. | β | 2021 | β |
| Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk. | Cho SB et al. | β | 2021 | β |
| A Family-Based Genome Wide Association Study of Externalizing Behaviors. | Barr PB et al. | β | 2020 | β |
| Alcohol Dependence and Reproductive Onset in Women, Updated: Analyses of Research and State-Level Administrative Data. | Waldron M et al. | β | 2020 | β |
| Alcohol's Unique Effects on Cognition in Women: A 2020 (Re)view to Envision Future Research and Treatment. | Fama R et al. | β | 2020 | β |
| Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis. | Salvatore JE et al. | β | 2020 | β |
| A Pilot Follow-Up Study of Older Alcohol-Dependent COGA Adults. | Chan G et al. | β | 2019 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them. | Patrick CJ et al. | β | 2019 | β |
| Positive and negative reinforcement are differentially associated with alcohol consumption as a function of alcohol dependence. | Cho SB et al. | β | 2019 | β |
| Reliability and validity of an internalizing symptom scale based on the adolescent and adult Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). | Acion L et al. | β | 2019 | β |
| The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample. | Johnson EC et al. | β | 2019 | β |
| The interaction of sociodemographic risk factors and measures of nicotine dependence in predicting maternal smoking during pregnancy. | Houston-Ludlam AN et al. | β | 2019 | β |
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | Olfson E et al. | β | 2018 | β |
| Genetic influences on conduct disorder. | Salvatore JE et al. | β | 2018 | β |
| Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. | Su J et al. | β | 2018 | β |
| Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink. | Waldron M et al. | β | 2018 | β |
| A GABRA2 polymorphism improves a model for prediction of drinking initiation. | Kuperman S et al. | β | 2017 | β |
| A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. | Kamarajan C et al. | β | 2017 | β |
| Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. | Bucholz KK et al. | β | 2017 | β |
| Executive Functions, Memory, and Social Cognitive Deficits and Recovery in Chronic Alcoholism: A Critical Review to Inform Future Research. | Le Berre AP et al. | β | 2017 | β |
| Genetic correlates of the development of theta event related oscillationsΒ in adolescents and young adults. | Chorlian DB et al. | β | 2017 | β |
| Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. | Agrawal A et al. | β | 2017 | β |
| Single Motherhood, Alcohol Dependence, and Smoking During Pregnancy: A Propensity Score Analysis. | Waldron M et al. | β | 2017 | β |
| A Propensity Scoring Approach to Characterizing the Effects of Maternal Smoking During Pregnancy on Offspring's Initial Responses to Cigarettes and Alcohol. | Bidwell LC et al. | β | 2016 | β |
| Hypothalamic-pituitary-adrenal axis response to acute psychosocial stress: Effects of biological sex and circulating sex hormones. | Stephens MA et al. | β | 2016 | β |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | β | 2016 | β |
| Are genetic variants for tobacco smoking associated with cannabis involvement? | Agrawal A et al. | β | 2015 | β |
| Association of substance dependence phenotypes in the COGA sample. | Wetherill L et al. | β | 2015 | β |
| Candidate gene-environment interaction research: reflections and recommendations. | Dick DM et al. | β | 2015 | β |
| Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. | Kamarajan C et al. | β | 2015 | β |
| Gender modulates the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | β | 2015 | β |
| Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample. | Aliev F et al. | β | 2015 | β |
| Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior. | Salvatore JE et al. | β | 2015 | β |
| Parental separation, parental alcoholism, and timing of first sexual intercourse. | Waldron M et al. | β | 2015 | β |
| Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. | Salvatore JE et al. | β | 2015 | β |
| A family-based robust multivariate association test using maximum statistic. | Hsieh TJ et al. | β | 2014 | β |
| Alcohol dependence and reproductive timing in African and European ancestry women: findings in a midwestern twin cohort. | Waldron M et al. | β | 2014 | β |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | β | 2014 | β |
| DSM-5 cannabis use disorder: a phenotypic and genomic perspective. | Agrawal A et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Family-based association analysis of alcohol dependence criteria and severity. | Wetherill L et al. | β | 2014 | β |
| Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. | Dick DM et al. | β | 2014 | β |
| Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. | Kapoor M et al. | β | 2014 | β |
| Have the genetics of cannabis involvement gone to pot? | Agrawal A et al. | β | 2014 | β |
| Risks for early substance involvement associated with parental alcoholism and parental separation in an adolescent female cohort. | Waldron M et al. | β | 2014 | β |
| Alcoholism and timing of separation in parents: findings in a midwestern birth cohort. | Waldron M et al. | β | 2013 | β |
| A model to determine the likely age of an adolescent's first drink of alcohol. | Kuperman S et al. | β | 2013 | β |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | β | 2013 | β |
| Genetic influences on craving for alcohol. | Agrawal A et al. | β | 2013 | β |
| How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity. | Dick DM et al. | β | 2013 | β |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | β | 2013 | β |
| The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems. | Meyers JL et al. | β | 2013 | β |
| ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. | Bierut LJ et al. | β | 2012 | β |
| Family-based genome-wide association study of frontal ΞΈ oscillations identifies potassium channel gene KCNJ6. | Kang SJ et al. | β | 2012 | β |
| Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. | Han S et al. | β | 2012 | β |
| Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau(). | Zhu W et al. | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | β | 2011 | β |
| Genome-wide association study of conduct disorder symptomatology. | Dick DM et al. | β | 2011 | β |
| Statistical Analysis in Genetic Studies of Mental Illnesses. | Zhang H | β | 2011 | β |
| The AVPR1A gene and substance use disorders: association, replication, and functional evidence. | Maher BS et al. | β | 2011 | β |
| The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. | Chen X et al. | β | 2011 | β |
| An Association Test for Multiple Traits Based on the Generalized Kendall's Tau. | Zhang H et al. | β | 2010 | β |
| A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ). | Kramer JR et al. | β | 2010 | β |
| Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | Dick DM et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| Linkage analysis of alcohol dependence symptoms in the community. | Hansell NK et al. | β | 2010 | β |
| NIAAA: advancing alcohol research for 40 years. | Warren KR et al. | β | 2010 | β |
| Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [ΒΉΒΉC]raclopride. | Urban NB et al. | β | 2010 | β |
| Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees. | Diao G et al. | β | 2010 | β |
| Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. | Agrawal A et al. | β | 2009 | β |
| Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. | Roopesh BN et al. | β | 2009 | β |
| A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. | Ghosh S et al. | β | 2008 | β |
| A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. | Dick DM et al. | β | 2008 | β |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | β | 2008 | β |
| Systems genetics of alcoholism. | Sloan CD et al. | β | 2008 | β |
| The P300 as an electrophysiological probe of alcohol expectancy. | Fishman I et al. | β | 2008 | β |
| Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. | Rangaswamy M et al. | β | 2007 | β |
| Detection of genes for ordinal traits in nuclear families and a unified approach for association studies. | Zhang H et al. | β | 2006 | β |
| Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. | MacLaren EJ et al. | β | 2006 | β |
| Semiparametric variance-component models for linkage and association analyses of censored trait data. | Diao G et al. | β | 2006 | β |
| Should DSM-V include dimensional diagnostic criteria for alcohol use disorders? | Helzer JE et al. | β | 2006 | β |
| The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. | Dick DM et al. | β | 2006 | β |
| A comparison of discrete versus continuous environment in a variance components-based linkage analysis of the COGA data. | Viel KR et al. | β | 2005 | β |
| Analysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage. | Reck BH et al. | β | 2005 | β |
| A powerful and robust method for mapping quantitative trait loci in general pedigrees. | Diao G et al. | β | 2005 | β |
| Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. | Edenberg HJ et al. | β | 2005 | β |
| Relationship of age of first drink to child behavioral problems and family psychopathology. | Kuperman S et al. | β | 2005 | β |
| A genome-wide screen for genes influencing conduct disorder. | Dick DM et al. | β | 2004 | β |
| Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. | Jones KA et al. | β | 2004 | β |
| Resting EEG in offspring of male alcoholics: beta frequencies. | Rangaswamy M et al. | β | 2004 | β |
| The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics. | Vieten C et al. | β | 2004 | β |
| Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. | Edenberg HJ et al. | β | 2004 | β |
| Alcohol-related ERP changes recorded from different modalities: a topographic analysis. | Cohen HL et al. | β | 2002 | β |
| Beta power in the EEG of alcoholics. | Rangaswamy M et al. | β | 2002 | β |
| Comparison of male adolescent-report of attention-deficit/hyperactivity disorder (ADHD) symptoms across two cultures using latent class and principal components analysis. | Rasmussen ER et al. | β | 2002 | β |
| Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism. | Bierut LJ et al. | β | 2002 | β |
| Relationship inference from trios of individuals, in the presence of typing error. | Sieberts SK et al. | β | 2002 | β |
| The collaborative study on the genetics of alcoholism: an update. | Edenberg HJ | β | 2002 | β |
| Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. | Almasy L et al. | β | 2001 | β |
| A genome screen of maximum number of drinks as an alcoholism phenotype. | Saccone NL et al. | β | 2000 | β |
| Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. | Williams JT et al. | β | 1999 | β |
| Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. | Williams JT et al. | β | 1999 | β |
| Is working memory intact in alcoholics? An ERP study. | Zhang XL et al. | β | 1997 | β |