TDT with covariates and genomic screens with mod scores: their behavior on simulated data.
paper
Primary
Public
Unavailable
- Authors
- Rice, J P; Neuman, R J; Hoshaw, S L; Daw, E W; Gu, C
- Year
- 1995
- Journal
- Genetic epidemiology
- PMID
- 8787990
- DOI
- 10.1002/gepi.1370120623
We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The Collaborative Study on the Genetics of Alcoholism. | 1995 | 31798102 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs. | Lou XY et al. | — | 2021 | → |
| Case-Parent Trio Studies in Cleft Lip and Palate. | Khan MI et al. | — | 2020 | → |
| Application of association mapping to understanding the genetic diversity of plant germplasm resources. | Abdurakhmonov IY et al. | — | 2008 | → |
| Linkage and association: basic concepts. | Borecki IB et al. | — | 2008 | → |
| Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles. | Tiwari HK et al. | — | 2008 | → |
| Approaches to handling incomplete data in family-based association testing. | Van Steen K et al. | — | 2007 | → |
| Advances in statistical human genetics over the last 25 years. | Elston RC et al. | — | 2006 | → |
| A perspective on epistasis: limits of models displaying no main effect. | Culverhouse R et al. | — | 2002 | → |
| Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. | Schulze TG et al. | — | 2002 | → |
| Nonsyndromic cleft lip with or without cleft palate in China: assessment of candidate regions. | Marazita ML et al. | — | 2002 | → |
| Assessment of parent-of-origin effects in linkage analysis of quantitative traits. | Hanson RL et al. | — | 2001 | → |
| Linkage and association: basic concepts. | Borecki IB et al. | — | 2001 | → |
| Family-based association studies. | Zhao H | — | 2000 | → |
| Power comparison of parametric and nonparametric linkage tests in small pedigrees. | Sham PC et al. | — | 2000 | → |
| Search for schizophrenia susceptibility genes. | Pulver AE | — | 2000 | → |
| Covariates in linkage analysis. | Rice JP et al. | — | 1999 | → |
| Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. | Maestri NE et al. | — | 1997 | → |
| Exact transmission-disequilibrium tests with multiallelic markers. | Cleves MA et al. | — | 1997 | → |
| Transmission/disequilibrium tests for multiallelic loci. | Sham P | — | 1997 | → |
| Affecteds-only linkage methods are not a panacea. | Greenberg DA et al. | — | 1996 | → |
| A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). | Reich T | — | 1996 | → |
| General score tests for associations of genetic markers with disease using cases and their parents. | Schaid DJ | — | 1996 | → |
| The TDT and other family-based tests for linkage disequilibrium and association. | Spielman RS et al. | — | 1996 | → |
| The Collaborative Study on the Genetics of Alcoholism. | — | — | 1995 | → |