Are genetic variants for tobacco smoking associated with cannabis involvement?
- Authors
- Agrawal, Arpana; Lynskey, Michael T; Kapoor, Manav; Bucholz, Kathleen K; Edenberg, Howard J; Schuckit, Marc; Brooks, Andrew; Hesselbrock, Victor; Kramer, John; Saccone, Nancy; Tischfield, Jay; Bierut, Laura J
- Year
- 2015
- Journal
- Drug and alcohol dependence
- PMID
- 25770649
- DOI
- 10.1016/j.drugalcdep.2015.02.029
- PMCID
- PMC4443812
BACKGROUND: Cannabis users are highly likely to also be tobacco cigarette smokers and a proportion of this comorbidity is attributable to shared genetic influences. Three large meta-analyses of genomewide association studies (GWAS) of tobacco smoking have identified multiple genomewide significant (p<5×10(-8)) single nucleotide polymorphisms (SNPs). We examine whether these SNPs are associated with tobacco smoking and with cannabis involvement in an independent sample. METHOD: Eleven SNPs associated with cigarettes per day (CPD), ever versus never smoking and current smoking/smoking cessation at p<5×10(-8) were selected from three published meta-analyses. Association analyses were conducted with similar tobacco smoking measures in 2716 European-American subjects from the Study of Addictions Genes and Environment (SAGE) and with lifetime and current cannabis use and DSM-IV cannabis abuse/dependence. RESULTS: Cannabis use and tobacco smoking correlated at 0.54. Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence. Rs6265 in BDNF was associated with smoking initiation, as in the original meta-analysis and also with lifetime cannabis use. Associations with cannabis involvement were no longer significant upon adjustment for the tobacco smoking measures. CONCLUSIONS: The modest associations between cannabis involvement and SNPs for tobacco smoking were not independent of the comorbidity between tobacco and cannabis involvement. Larger samples of individuals might be required to articulate the specific genetic architecture of cannabis involvement.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings. | 2016 | 27114204 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| <i>BDNF</i> gene polymorphisms and substance use disorders: a systematic review. | Peregud D et al. | — | 2026 | → |
| A Bivariate Twin Study of Lifetime cannabis Initiation and Lifetime Regular Tobacco Smoking Across Three Different Countries. | Zellers S et al. | — | 2024 | → |
| Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers. | Qi FY et al. | — | 2022 | → |
| Measuring the temporal association between cannabis and tobacco use among Co-using young adults using ecological momentary assessment. | Wilhelm J et al. | — | 2020 | → |
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| Prevalence, correlates, and trends in tobacco use and cessation among current, former, and never adult marijuana users with a history of tobacco use, 2005-2014. | Schauer GL et al. | — | 2017 | → |
| Genetic and Environmental Factors Associated with Cannabis Involvement. | Bogdan R et al. | — | 2016 | → |
| The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings. | Agrawal A et al. | — | 2016 | → |