A population-based twin study in women of smoking initiation and nicotine dependence.
paper
Cited
Public
Unavailable
- Authors
- Kendler, K S; Neale, M C; Sullivan, P; Corey, L A; Gardner, C O; Prescott, C A
- Year
- 1999
- Journal
- Psychological medicine
- PMID
- 10218922
- DOI
- 10.1017/s0033291798008022
BACKGROUND: The development of drug dependence requires prior initiation. What is the relationship between the risk factors for initiation and dependence? METHODS: Using smoking as a model addiction, we assessed smoking initiation (SI) and nicotine dependence (ND) by personal interview in 1898 female twins from the population-based Virginia Twin Registry. We developed a twin structural equation model that estimates the correlation between the liability to SI and the liability to ND, given SI. RESULTS: The liabilities to SI and ND were substantially correlated but not identical. Heritable factors played an important aetiological role in SI and in ND. While the majority of genetic risk factors for ND were shared with SI, a distinct set of familial factors, which were probably partly genetic, solely influenced the risk for ND. SI was associated with low levels of education and religiosity, high levels of neuroticism and extroversion and a history of a wide range of psychiatric disorders. ND was associated with low levels of education, extroversion, mastery, and self-esteem, high levels of neuroticism and dependency and a history of mood and alcohol use disorders. CONCLUSIONS: The aetiological factors that influence SI and ND, while overlapping, are not perfectly correlated. One set of genetic factors plays a significant aetiological role in both SI and ND, while another set of familial factors, probably in part genetic, solely influences ND. Some risk factors for SI and ND impact similarly on both stages, some act at only one stage and others impact differently and even in opposite directions at the two stages. The pathway to substance dependence is complex and involves multiple genetic and environmental risk factors.
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| Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome. | Salles J et al. | — | 2024 | → |
| Examining common and distinct contributions to the etiology of suicide attempt and reattempt. | Lannoy S et al. | — | 2023 | → |
| The moderation of the genetic risk for alcohol and drug use disorders in a Swedish national sample by the genetic aptitude for educational attainment. | Kendler KS et al. | — | 2023 | → |
| An ethical analysis of endoscopic therapy decision-making in patients with refractory substance use disorder and chronic pancreatitis. | Al-Moussally F et al. | — | 2022 | → |
| The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems. | Ksinan AJ et al. | — | 2022 | → |
| Combining Structural-Equation Modeling with Genomic-Relatedness-Matrix Restricted Maximum Likelihood in OpenMx. | Kirkpatrick RM et al. | — | 2021 | → |
| Evidence for a Causal Relationship Between Academic Achievement and Cigarette Smoking. | Kendler KS et al. | — | 2021 | → |
| Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples. | Fan R et al. | — | 2021 | → |
| Genetic and environmental influences on the progression from alcohol use disorder to alcohol-related medical conditions. | Edwards AC et al. | — | 2021 | → |
| Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms. | Brynildsen JK et al. | — | 2021 | → |
| Meta-Analysis of Transcriptome-Wide Association Studies across 13 Brain Tissues Identified Novel Clusters of Genes Associated with Nicotine Addiction. | Ye Z et al. | — | 2021 | → |
| Nicotinic acetylcholine gene cluster CHRNA5-A3-B4 variants influence smoking status in a Bangladeshi population. | Chaity NI et al. | — | 2021 | → |
| The Effect of Maternal Smoking on Offspring Smoking Is Unrelated to Heritable Personality Traits or Initial Subjective Experiences. | Weber TL et al. | — | 2021 | → |
| White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy. | Ye Z et al. | — | 2021 | → |
| 2018 Langley Award for Basic Research on Nicotine and Tobacco: Bringing Precision Medicine to Smoking Cessation. | Bierut LJ | — | 2020 | → |
| Maternal Drinking and Child Emotional and Behavior Problems. | Lund IO et al. | — | 2020 | → |
| Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction. | Wittenberg RE et al. | — | 2020 | → |
| Stability in effects of different smoking-related polygenic risk scores over age and smoking phenotypes. | Deutsch AR et al. | — | 2020 | → |
| The association between gender roles and smoking initiation among women and adolescent girls. | Ozbay N et al. | — | 2020 | → |
| White matter integrity and nicotine dependence in smokers: evaluating vertical and horizontal pleiotropy | Ye Z et al. | — | 2020 | — |
| Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood: a Finnish longitudinal twin study. | Virtanen S et al. | — | 2019 | → |
| Cigarette smoking and personality: interrogating causality using Mendelian randomisation. | Sallis HM et al. | — | 2019 | → |
| Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco. | Sharp BM et al. | — | 2019 | → |
| Nicotine dependence among adolescents in the European Union: How many and who are affected? | Coban FR et al. | — | 2019 | → |
| Identifying the contribution of prenatal risk factors to offspring development and psychopathology: What designs to use and a critique of literature on maternal smoking and stress in pregnancy. | Rice F et al. | — | 2018 | → |
| Is Optimism Associated With Healthier Cardiovascular-Related Behavior? Meta-Analyses of 3 Health Behaviors. | Boehm JK et al. | — | 2018 | → |
| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. | Hines LA et al. | — | 2018 | → |
| The dopamine transporter role in psychiatric phenotypes. | Salatino-Oliveira A et al. | — | 2018 | → |
| The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design. | Iacono WG et al. | — | 2018 | → |
| Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. | Melroy-Greif WE et al. | — | 2017 | → |
| Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. | Yin X et al. | — | 2017 | → |
| Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder. | Brenton A et al. | — | 2017 | → |
| Predictors and mental health outcomes of potentially traumatic event exposure. | Overstreet C et al. | — | 2017 | → |
| Prevalence of Cigarette Smoking and Nicotine Dependence in Men and Women Residing in Two Provinces in China. | Ma Y et al. | — | 2017 | → |
| Smoking status and attractiveness among exemplar and prototypical identical twins discordant for smoking. | Skinner AL et al. | — | 2017 | → |
| Validation Study of a Predictive Algorithm to Evaluate Opioid Use Disorder in a Primary Care Setting. | Sharma M et al. | — | 2017 | → |
| Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with age of smoking initiation in male schizophrenia smokers. | Zhang XY et al. | — | 2016 | → |
| Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction. | Cadoni C | — | 2016 | → |
| Genetic and environmental components to self-induced vomiting. | Peterson CM et al. | — | 2016 | → |
| Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. | Agrawal A et al. | — | 2016 | → |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | — | 2016 | → |
| Stress is a principal factor that promotes tobacco use in females. | Torres OV et al. | — | 2016 | → |
| Amphetamine self-administration and dopamine function: assessment of gene × environment interactions in Lewis and Fischer 344 rats. | Meyer AC et al. | — | 2015 | → |
| Are genetic variants for tobacco smoking associated with cannabis involvement? | Agrawal A et al. | — | 2015 | → |
| Association of 5-HTTLPR polymorphism with smoking behaviors: A meta-analysis. | Li H et al. | — | 2015 | → |
| Childhood and adolescence risk factors and development of depressive symptoms: the 32-year prospective Young Finns follow-up study. | Elovainio M et al. | — | 2015 | → |
| Comparison of Twin and Extended Pedigree Designs for Obtaining Heritability Estimates. | Docherty AR et al. | — | 2015 | → |
| COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers. | Bowers H et al. | — | 2015 | → |
| Developmental Changes in Genetic and Shared Environmental Contributions to Smoking Initiation and Subsequent Smoking Quantity in Adolescence and Young Adulthood. | Bares CB et al. | — | 2015 | → |
| Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women. | Sartor CE et al. | — | 2015 | → |
| Genetic and environmental influences on adolescents' smoking involvement: a multi-informant twin study. | Seglem KB et al. | — | 2015 | → |
| Genetic and Environmental Influences on Smoking Behavior across Adolescence and Young Adulthood in the Virginia Twin Study of Adolescent Behavioral Development and the Transitions to Substance Abuse Follow-Up. | Do EK et al. | — | 2015 | → |
| Genetic and Environmental Interplay in Adolescent Substance Use Disorders. | Hines LA et al. | — | 2015 | → |
| Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. | Gelernter J et al. | — | 2015 | → |
| Multiple mechanisms influencing the relationship between alcohol consumption and peer alcohol use. | Edwards AC et al. | — | 2015 | → |
| Personality and dementia. | Cipriani G et al. | — | 2015 | → |
| Smoking is unrelated to female sexual function. | Costa RM et al. | — | 2015 | → |
| The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. | Hines LA et al. | — | 2015 | → |
| The pharmacogenetics of alcohol use disorder. | Jones JD et al. | — | 2015 | → |
| The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders. | Grant JD et al. | — | 2015 | → |
| A multivariate twin study of the dimensions of religiosity and common psychiatric and substance use disorders. | Vance T et al. | — | 2014 | → |
| A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol. | Ware JJ et al. | — | 2014 | → |
| Attention-deficit/hyperactivity disorder subtypes and substance use and use disorders in NESARC. | De Alwis D et al. | — | 2014 | → |
| COgnitive-pulmonary disease. | Cleutjens FA et al. | — | 2014 | → |
| Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. | Harenza JL et al. | — | 2014 | → |
| Have the genetics of cannabis involvement gone to pot? | Agrawal A et al. | — | 2014 | → |
| Polygenic risk scores for smoking: predictors for alcohol and cannabis use? | Vink JM et al. | — | 2014 | → |
| Risk factors influencing smoking behavior: a Turkish twin study. | Oncel SY et al. | — | 2014 | → |
| Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. | Wang S et al. | — | 2014 | → |
| Smoke and Mirrors: The Perceived Benefits of Continued Tobacco use Among Current Smokers. | Klein H et al. | — | 2014 | → |
| Smoking and major depressive disorder in Chinese women. | He Q et al. | — | 2014 | → |
| The Influences of Genetic and Environmental Factors on Methylome-wide Association Studies for Human Diseases. | Sun YV | — | 2014 | → |
| Toward a comprehensive developmental model of smoking initiation and nicotine dependence. | García-Rodríguez O et al. | — | 2014 | → |
| Does personality affect risk for dementia? A systematic review and meta-analysis. | Low LF et al. | — | 2013 | → |
| Dual growth of adolescent smoking and drinking: evidence for an interaction between the mu-opioid receptor (OPRM1) A118G polymorphism and sex. | Kleinjan M et al. | — | 2013 | → |
| Early smoking onset and risk for subsequent nicotine dependence: a monozygotic co-twin control study. | Kendler KS et al. | — | 2013 | → |
| Exploring alternate processes contributing to the association between maternal smoking and the smoking behavior among young adult offspring. | Selya AS et al. | — | 2013 | → |
| Genetic sensitivity to peer behaviors: 5HTTLPR, smoking, and alcohol consumption. | Daw J et al. | — | 2013 | → |
| Nicotine dependence matters: examining longitudinal association between smoking and physical activity among Canadian adults. | Azagba S et al. | — | 2013 | → |
| Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism. | Zhang X et al. | — | 2013 | → |
| Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers. | Yang Z et al. | — | 2013 | → |
| Smoking intensity and its relation to general health of the students of kerman university of medical sciences, iran. | Nasirian M et al. | — | 2013 | → |
| Why does early sexual intercourse predict subsequent maladjustment? Exploring potential familial confounds. | Donahue KL et al. | — | 2013 | → |
| Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. | Bousman CA et al. | — | 2012 | → |
| A population-based study of familial and individual-specific environmental contributions to traumatic event exposure and posttraumatic stress disorder symptoms in a Norwegian twin sample. | Amstadter AB et al. | — | 2012 | → |
| Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. | Kenna GA et al. | — | 2012 | → |
| A study of mental health and dyadic adjustment between smokers and nonsmokers. | Kord Tamini B et al. | — | 2012 | → |
| A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation. | Verhagen M et al. | — | 2012 | → |
| A twin study of depression and nicotine dependence: shared liability or causal relationship? | Edwards AC et al. | — | 2012 | → |
| Exploring the relationships between tobacco smoking and schizophrenia in first-degree relatives. | Ferchiou A et al. | — | 2012 | → |
| Gambling, disordered gambling and their association with major depression and substance use: a web-based cohort and twin-sibling study. | Blanco C et al. | — | 2012 | → |
| Genetic and environmental etiology of nicotine use in Sri Lankan male twins. | Zavos HM et al. | — | 2012 | → |
| Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms. | Palmer RH et al. | — | 2012 | → |
| Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. | Babic M et al. | — | 2012 | → |
| Parent, sibling and peer influences on smoking initiation, regular smoking and nicotine dependence. Results from a genetically informative design. | Scherrer JF et al. | — | 2012 | → |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | — | 2012 | → |
| Religiosity and tobacco and alcohol use in a Brazilian shantytown. | Lucchetti G et al. | — | 2012 | → |
| Risk factors for adolescent smoking: parental smoking and the mediating role of nicotine dependence. | Selya AS et al. | — | 2012 | → |
| Suicidal behavior, smoking, and familial vulnerability. | Scherrer JF et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| The profile and familiality of personality traits in mood disorder families. | Wu PJ et al. | — | 2012 | → |
| Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M et al. | — | 2012 | → |
| ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. | Chen J et al. | — | 2011 | → |
| A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependence. | Agrawal A et al. | — | 2011 | → |
| A population-based twin study of the genetic and environmental relationship of major depression, regular tobacco use and nicotine dependence. | Edwards AC et al. | — | 2011 | → |
| Are smokers interested in genetic testing for smoking addiction? A socio-cognitive approach. | Smerecnik C et al. | — | 2011 | → |
| Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. | Ware JJ et al. | — | 2011 | → |
| Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. | Jackson KJ et al. | — | 2011 | → |
| Behavior matters. | Fisher EB et al. | — | 2011 | → |
| Dizziness and the genetic influences on subjective experiences to initial cigarette use. | Haberstick BC et al. | — | 2011 | → |
| Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. | Breitling LP et al. | — | 2011 | → |
| Factors underlying prefrontal and insula structural alterations in smokers. | Zhang X et al. | — | 2011 | → |
| Genetics of the association between intelligence and nicotine dependence: a study of male Swedish twins. | Modig K et al. | — | 2011 | → |
| Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders. | Rijsdijk FV et al. | — | 2011 | → |
| Interplay between heritability of smoking and environmental conditions? A comparison of two birth cohorts. | Vink JM et al. | — | 2011 | → |
| Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study. | Gizer IR et al. | — | 2011 | → |
| Stressing zebrafish for behavioral genetics. | Clark KJ et al. | — | 2011 | → |
| The alternative five-factor model of personality, nicotine dependence and relapse after treatment for smoking cessation. | Nieva G et al. | — | 2011 | → |
| The German multi-centre study on smoking-related behavior-description of a population-based case-control study. | Lindenberg A et al. | — | 2011 | → |
| The relationship between the genetic and environmental influences on common externalizing psychopathology and mental wellbeing. | Kendler KS et al. | — | 2011 | → |
| Treatment for tobacco dependence: a potential application for stratified medicine? | Brock AJ et al. | — | 2011 | → |
| Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. | Li MD et al. | — | 2010 | → |
| Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects. | Nedic G et al. | — | 2010 | → |
| Changes in genetic and environmental influences on the development of nicotine dependence and major depressive disorder from middle adolescence to early adulthood. | Tully EC et al. | — | 2010 | → |
| Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. | Wang J et al. | — | 2010 | → |
| Dependent stressful life events and prior depressive episodes in the prediction of major depression: the problem of causal inference in psychiatric epidemiology. | Kendler KS et al. | — | 2010 | → |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | — | 2010 | → |
| Initial response to cigarettes predicts rate of progression to regular smoking: findings from an offspring-of-twins design. | Sartor CE et al. | — | 2010 | → |
| Marriage and Divorce: A genetic perspective. | Jerskey BA et al. | — | 2010 | → |
| Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins. | Agrawal A et al. | — | 2010 | → |
| Relationships of personality and psychiatric disorders to multiple domains of smoking motives and dependence in middle-aged adults. | Kahler CW et al. | — | 2010 | → |
| The relationship between genetic influences on alcohol dependence and on patterns of alcohol consumption. | Kendler KS et al. | — | 2010 | → |
| Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits. | Hong LE et al. | — | 2009 | → |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | — | 2009 | → |
| Familial and non-familial smoking: effects on smoking and nicotine dependence. | Brook JS et al. | — | 2009 | → |
| Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases? | Quaak M et al. | — | 2009 | → |
| Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. | Wang JC et al. | — | 2009 | → |
| Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases. | Quaak M et al. | — | 2009 | → |
| Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. | Chen LS et al. | — | 2009 | → |
| Is education causally related to better health? A twin fixed-effect study in the USA. | Fujiwara T et al. | — | 2009 | → |
| Modeling the genetic and environmental association between peer group deviance and cannabis use in male twins. | Gillespie NA et al. | — | 2009 | → |
| Pathways to cannabis abuse: a multi-stage model from cannabis availability, cannabis initiation and progression to abuse. | Gillespie NA et al. | — | 2009 | → |
| Personality, psychiatric disorders, and smoking in middle-aged adults. | Kahler CW et al. | — | 2009 | → |
| Relationship of nicotine dependence, subsyndromal and pathological gambling, and other psychiatric disorders: data from the National Epidemiologic Survey on Alcohol and Related Conditions. | Grant JE et al. | — | 2009 | → |
| Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. | Wang JC et al. | — | 2009 | → |
| Role of genetic variants in the CHRNA5-CHRNA3-CHRNB4 cluster in nicotine dependence risk: importance of gene-environment interplay. | Greenbaum L et al. | — | 2009 | → |
| Smoking cessation pharmacotherapy. | Frishman WH | — | 2009 | → |
| The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study. | Styn MA et al. | — | 2009 | → |
| Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X et al. | — | 2009 | → |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. | Thorgeirsson TE et al. | — | 2008 | → |
| Cannabinoid receptor 1 gene association with nicotine dependence. | Chen X et al. | — | 2008 | → |
| Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour? | von der Pahlen B et al. | — | 2008 | → |
| Earlier violent television exposure and later drug dependence. | Brook DW et al. | — | 2008 | → |
| Educational attainment, smoking initiation and lifetime nicotine dependence among male Vietnam-era twins. | McCaffery JM et al. | — | 2008 | → |
| Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. | Agrawal A et al. | — | 2008 | → |
| Genes and cigarette smoking. | Munafò MR et al. | — | 2008 | → |
| Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. | Xian H et al. | — | 2008 | → |
| Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. | Kendler KS et al. | — | 2008 | → |
| Genetic factors contribute to the association between peers and young adults smoking: univariate and multivariate behavioral genetic analyses. | Harakeh Z et al. | — | 2008 | → |
| Genetics of nicotine dependence and pharmacotherapy. | Lessov-Schlaggar CN et al. | — | 2008 | → |
| Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. | Portugal GS et al. | — | 2008 | → |
| Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence. | Laucht M et al. | — | 2008 | → |
| Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. | Li MD et al. | — | 2008 | → |
| Genomewide linkage survey of nicotine dependence phenotypes. | Sullivan PF et al. | — | 2008 | → |
| Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses. | Li MD | — | 2008 | → |
| Is there evidence for symptoms of cannabis withdrawal in the national epidemiologic survey of alcohol and related conditions? | Agrawal A et al. | — | 2008 | → |
| Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background. | Loukola A et al. | — | 2008 | → |
| Primary care physicians' willingness to offer a new genetic test to tailor smoking treatment, according to test characteristics. | Shields AE et al. | — | 2008 | → |
| Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. | Sartor CE et al. | — | 2008 | → |
| Transitions to regular smoking and to nicotine dependence in women using cannabis. | Agrawal A et al. | — | 2008 | → |
| Addressing tobacco-related health disparities. | Moolchan ET et al. | — | 2007 | → |
| Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. | Guo S et al. | — | 2007 | → |
| Childhood sexual abuse and the course of alcohol dependence development: findings from a female twin sample. | Sartor CE et al. | — | 2007 | → |
| Chromosomal loci that influence oral nicotine consumption in C57BL/6J x C3H/HeJ F2 intercross mice. | Li XC et al. | — | 2007 | → |
| Concordance rates for smoking among African-American twins. | Whitfield KE et al. | — | 2007 | → |
| Effects of cigarette smoking and family history of alcoholism on sweet taste perception and food cravings in women. | Pepino MY et al. | — | 2007 | → |
| Evidence for specificity of transmission of alcohol and nicotine dependence in an offspring of twins design. | Volk HE et al. | — | 2007 | → |
| Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? | Morley KI et al. | — | 2007 | → |
| Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. | Fowler T et al. | — | 2007 | → |
| Gender differences and developmental change in externalizing disorders from late adolescence to early adulthood: A longitudinal twin study. | Hicks BM et al. | — | 2007 | → |
| Genes, time to first cigarette and nicotine dependence in a general population sample of young adults. | Haberstick BC et al. | — | 2007 | → |
| Heritability of illicit drug use and transition to dependence in Southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| [Influence of parental tobacco dependence and parenting styles on adolescents' tobacco use]. | Courtois R et al. | — | 2007 | → |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | — | 2007 | → |
| Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants. | Gillespie NA et al. | — | 2007 | → |
| On the development of nicotine dependence in adolescence. | Kandel DB et al. | — | 2007 | → |
| Overview of the pharmacogenomics of cigarette smoking. | Ho MK et al. | — | 2007 | → |
| Primary care physicians' concerns about offering a genetic test to tailor smoking cessation treatment. | Levy DE et al. | — | 2007 | → |
| Psychological characteristics associated with tobacco smoking behavior. | Rondina Rde C et al. | — | 2007 | → |
| Psychometric properties of DSM assessments of illicit drug abuse and dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). | Lynskey MT et al. | — | 2007 | → |
| RhoA, encoding a Rho GTPase, is associated with smoking initiation. | Chen X et al. | — | 2007 | → |
| Smoking cessation pharmacotherapy--nicotine and non-nicotine preparations. | Frishman WH | — | 2007 | → |
| Stress- and cue-induced cigarette craving: effects of a family history of smoking. | Colamussi L et al. | — | 2007 | → |
| The association between conduct problems and the initiation and progression of marijuana use during adolescence: a genetic analysis across time. | Shelton K et al. | — | 2007 | → |
| The Heaviness of Smoking Index as a predictor of smoking cessation in Canada. | Chaiton MO et al. | — | 2007 | → |
| The Nicotine Dependence Syndrome Scale in Finnish smokers. | Broms U et al. | — | 2007 | → |
| The role of CYP2A6 in the emergence of nicotine dependence in adolescents. | Audrain-McGovern J et al. | — | 2007 | → |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | — | 2006 | → |
| A genome-wide screen for nicotine dependence susceptibility loci. | Swan GE et al. | — | 2006 | → |
| A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. | Li MD et al. | — | 2006 | → |
| An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health. | Timberlake DS et al. | — | 2006 | → |
| A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. | Morley KI et al. | — | 2006 | → |
| Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence. | Zhang L et al. | — | 2006 | → |
| Assortative mating for cigarette smoking and for alcohol consumption in female Australian twins and their spouses. | Agrawal A et al. | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| Cigarette smoking and incidence of first depressive episode: an 11-year, population-based follow-up study. | Klungsøyr O et al. | — | 2006 | → |
| Epidemiology and correlates of daily smoking and nicotine dependence among young adults in the United States. | Hu MC et al. | — | 2006 | → |
| Extensions to the modeling of initiation and progression: applications to substance use and abuse. | Neale MC et al. | — | 2006 | → |
| Gender differences in determinants of smoking initiation and persistence in California twins. | Hamilton AS et al. | — | 2006 | → |
| Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. | Pagan JL et al. | — | 2006 | → |
| Genetic architecture of smoking behavior: a study of Finnish adult twins. | Broms U et al. | — | 2006 | → |
| Genetic correlations between smoking initiation and smoking behaviors in a twin sample. | Hardie TL et al. | — | 2006 | → |
| Illicit psychoactive substance use, abuse and dependence in a population-based sample of Norwegian twins. | Kendler KS et al. | — | 2006 | → |
| Is there heterogeneity among syndromes of substance use disorder for illicit drugs? | Beseler C et al. | — | 2006 | → |
| Methodological issues in the assessment of substance use phenotypes. | Neale MC et al. | — | 2006 | → |
| Muscle dissatisfaction and muscle-enhancing substance use: a population-based twin study in young adult men. | Raevuori A et al. | — | 2006 | → |
| Nicotine and non-nicotine smoking cessation pharmacotherapies. | Frishman WH et al. | — | 2006 | → |
| Pregnancy, smoking and birth outcomes. | Delpisheh A et al. | — | 2006 | → |
| The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. | McGue M et al. | — | 2006 | → |
| The developmental behavior genetics of drug involvement: overview and comments. | Zucker RA | — | 2006 | → |
| The implications of simultaneous smoking initiation for inferences about the genetics of smoking behavior from twin data. | Pergadia ML et al. | — | 2006 | → |
| The influence of genetics on nicotine dependence and the role of pharmacogenetics in treating the smoking habit. | Chatkin JM | — | 2006 | → |
| The mu-opioid receptor gene and smoking initiation and nicotine dependence. | Zhang L et al. | — | 2006 | → |
| Using the brain P300 response to identify novel phenotypes reflecting genetic vulnerability for adolescent substance misuse. | Yoon HH et al. | — | 2006 | → |
| Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. | Greenbaum L et al. | — | 2006 | → |
| Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. | Lerer E et al. | — | 2006 | → |
| A genome scan of neuroticism in nicotine dependent smokers. | Neale BM et al. | — | 2005 | → |
| Association of the serotonin transporter gene with smoking behavior. | Kremer I et al. | — | 2005 | → |
| Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians. | Shields AE et al. | — | 2005 | → |
| Children's hedonic judgments of cigarette smoke odor: effects of parental smoking and maternal mood. | Forestell CA et al. | — | 2005 | → |
| [Genetic basis of tobacco dependence]. | Barrueco M et al. | — | 2005 | → |
| Heritability of smoking initiation and nicotine dependence. | Vink JM et al. | — | 2005 | → |
| Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach. | Agrawal A et al. | — | 2005 | → |
| Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis. | Wang D et al. | — | 2005 | → |
| Nicotine dependence, depression, and gender: characterizing phenotypes based on withdrawal discomfort, response to smoking, and ability to abstain. | Pomerleau OF et al. | — | 2005 | → |
| Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence. | Swan GE et al. | — | 2005 | → |
| Personality correlates related to tobacco abstinence following treatment. | Hooten WM et al. | — | 2005 | → |
| Personality development: stability and change. | Caspi A et al. | — | 2005 | → |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | — | 2005 | → |
| A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. | Feng Y et al. | — | 2004 | → |
| A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. | Bierut LJ et al. | — | 2004 | → |
| A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. | Faraone SV et al. | — | 2004 | → |
| Association between dependent smoking and a polymorphism in the tyrosine hydroxylase gene in a prospective population-based study of adolescent health. | Olsson C et al. | — | 2004 | → |
| Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence. | Ling D et al. | — | 2004 | → |
| Association study of the Epac gene and tobacco smoking and nicotine dependence. | Chen X et al. | — | 2004 | → |
| Gene-environment interaction and the genetics of depression. | Lesch KP | — | 2004 | → |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | — | 2004 | → |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | — | 2004 | → |
| Genetics of tobacco use. | Maserejian NN et al. | — | 2004 | → |
| Grey lungs and blue moods: smoking cessation in the context of lifetime depression history. | Wilhelm K et al. | — | 2004 | → |
| Identifying shared environmental contributions to early substance use: the respective roles of peers and parents. | Walden B et al. | — | 2004 | → |
| Interacting effects of genetic predisposition and depression on adolescent smoking progression. | Audrain-McGovern J et al. | — | 2004 | → |
| Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. | Vink JM et al. | — | 2004 | → |
| MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake. | Lee M et al. | — | 2004 | → |
| Nicotine dependence. | Berrettini WH | — | 2004 | → |
| Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. | Anney RJ et al. | — | 2004 | → |
| Polymorphism of 5HT2A serotonin receptor gene is implicated in smoking addiction. | do Prado-Lima PA et al. | — | 2004 | → |
| Progress in searching for susceptibility loci and genes for smoking-related behaviour. | Li MD et al. | — | 2004 | → |
| Self-esteem and "at risk" women:determinants and relevance to sexual and HIV-related risk behaviors. | Sterk CE et al. | — | 2004 | → |
| A family history of smoking predicts heightened levels of stress-induced cigarette craving. | Erblich J et al. | — | 2003 | → |
| A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. | Li MD et al. | — | 2003 | → |
| Disabilities, quality of life, and mental disorders associated with smoking and nicotine dependence. | Schmitz N et al. | — | 2003 | → |
| Elucidating the role of genetic factors in smoking behavior and nicotine dependence. | Lerman C et al. | — | 2003 | → |
| Familial influences on adolescent smoking. | Avenevoli S et al. | — | 2003 | → |
| Genetic and environmental risk factors in adolescent substance use. | Silberg J et al. | — | 2003 | → |
| Genetic influence on cigarette-induced cardiovascular disease. | Wang XL et al. | — | 2003 | → |
| Genetic influences on smoking behavior and nicotine dependence: a review. | Yoshimasu K et al. | — | 2003 | → |
| Major depression and associated impairment: same or different genetic and environmental risk factors? | Foley DL et al. | — | 2003 | → |
| Modulation of gene expression by genetic and environmental heterogeneity in timing of a developmental milestone. | Eaves LJ et al. | — | 2003 | → |
| Nicotine as a modulator of behavior: beyond the inverted U. | Picciotto MR | — | 2003 | → |
| Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. | Kendler KS et al. | — | 2003 | → |
| Teachable moments for promoting smoking cessation: the context of cancer care and survivorship. | McBride CM et al. | — | 2003 | → |
| The genetic determinants of smoking. | Batra V et al. | — | 2003 | → |
| Tobacco smoking: current concepts in etiology and treatment. | Patkar AA et al. | — | 2003 | → |
| Twenty-first century tobacco use: it is not just a risk factor anymore. | Khurana S et al. | — | 2003 | → |
| Applying genetic approaches to the treatment of nicotine dependence. | Lerman C et al. | — | 2002 | → |
| Cigarette smoking and panic: the role of neuroticism. | Goodwin R et al. | — | 2002 | → |
| Current perspectives on smoking cessation among substance abusers. | Sullivan MA et al. | — | 2002 | → |
| Estimating two-stage models for genetic influences on alcohol, tobacco or drug use initiation and dependence vulnerability in twin and family data. | Heath AC et al. | — | 2002 | → |
| Gene-environment interaction effects on behavioral variation and risk of complex disorders: the example of alcoholism and other psychiatric disorders. | Heath AC et al. | — | 2002 | → |
| Persistence of cigarette smoking: familial liability and the role of nicotine dependence. | Johnson EO et al. | — | 2002 | → |
| Research on tobacco use among teenagers: ethical challenges. | Moolchan ET et al. | — | 2002 | → |
| Shared genetic vulnerability in alcohol and cigarette use and dependence. | Madden PA et al. | — | 2002 | → |
| Substance use among adolescents in Taiwan: associated personality traits, incompetence, and behavioral/emotional problems. | Kuo PH et al. | — | 2002 | → |
| The genetics of tobacco use: methods, findings and policy implications. | Hall W et al. | — | 2002 | → |
| Tobacco smoking as a chronic disease: notes on prevention and treatment. | Batra V et al. | — | 2002 | → |
| An association study of DRD5 with smoking initiation and progression to nicotine dependence. | Sullivan PF et al. | — | 2001 | → |
| An integrative approach for studying the etiology of alcoholism and other addictions. | Jacob T et al. | — | 2001 | → |
| Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. | Sullivan PF et al. | — | 2001 | → |
| New directions in the genetic mechanisms underlying nicotine addiction. | Munafò M et al. | — | 2001 | → |
| The relationship between cannabis use and other substance use in the general population. | Degenhardt L et al. | — | 2001 | → |
| Advances in non-nicotine pharmacotherapy for smoking cessation. | Covey LS et al. | — | 2000 | → |
| A review of tobacco smoking in adolescents: treatment implications. | Moolchan ET et al. | — | 2000 | → |
| Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. | Silverman MA et al. | — | 2000 | → |
| Smoking and the genetic contribution to alcohol-dependence risk. | Madden PA et al. | — | 2000 | → |
| Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. | Kendler KS et al. | — | 1999 | → |
| The genetic epidemiology of smoking. | Sullivan PF et al. | — | 1999 | → |
| The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins. | Koopmans JR et al. | — | 1999 | → |