Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study.

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Authors: Gizer, I R; Ehlers, C L; Vieten, C; Seaton-Smith, K L; Feiler, H S; Lee, J V; Segall, S K; Gilder, D A; Wilhelmsen, K C
Year: 2011
Journal: Psychological medicine
PMID: 20594377
DOI: 10.1017/S0033291710001273
PMCID: PMC3045476

#	Section	Preview
0	Methods — Participants	The present study utilized participants from the UCSF Family Alcoholism Study (Seaton et al., 2004;…
1	Methods — Participants	The UCSF Family Alcoholism Study sample consisted of 1548 women and 976 men with a mean age of 48.5…
2	Methods — Participants	An unselected general population sample of 147 individuals was recruited to assess phenotype base…
3	Methods — Participants	All participants were administered a modified version of the SSAGA (Bucholz et al., 1994), an…
4	Methods — DNA Collection and Genotyping	The DNA extraction procedure and genotyping protocol have been previously described (Wilhelmsen et…
5	Methods — DNA Collection and Genotyping	Prior to analysis, a number of quality control steps were undertaken to ensure the accuracy of the…
6	Methods — DNA Collection and Genotyping	across families were excluded from subsequent analysis. Pedcheck identified 3104 Mendelian errors…
7	Methods — Analysis	Both genotype and phenotype data were available for 1647 individuals, and phenotype but not genotype…
8	Methods — Analysis	Initial analyses were conducted to determine the potential of the DSM-IV nicotine dependence…
9	Methods — Analysis	The variance components approach to linkage incorporates information from affected and unaffected…
10	Methods — Analysis	Dichotomous phenotypes were modeled as latent normally distributed variables with a threshold above…
11	Methods — Analysis	SOLAR also allows for the simultaneous analysis of multiple traits as well as the inclusion of…
12	Methods — Analysis	For the linkage analysis of the 14 SSAGA nicotine dependence symptoms, the support intervals for…
13	Methods — Analysis	frequencies used to calculate allele sharing probabilities between relative pairs were estimated…
14	Results	The h2 estimate for the nicotine dependence diagnosis was significantly greater than 0 (p<.001), as…
15	Results	Variance components linkage analysis of the nicotine dependence diagnosis yielded evidence for…
16	Results	Notably, there was no evidence of heterogeneity in LOD scores across pedigrees as each family had an…
17	Results	Four additional loci yielded notable evidence of linkage (Table 1). The first locus represented a…
18	Results	Linkage results for the nicotine dependence diagnosis were then compared to the results from a…
19	Results	This conclusion was supported by subsequent analyses in which the alcohol dependence diagnosis was…

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Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study.

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