paperKB
coga / coga-kb
Help
Sign in

Chunk #17 — Results

Source
Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study.
Embedded
yes

Text

Four additional loci yielded notable evidence of linkage (Table 1). The first locus represented a second peak located on chromosome 2 at 123 cM nearest marker D2S160 (LOD = 1.95, point-wise empirical p = .00144) with a support interval that extended from 109 – 132 cM. The second locus was found on chromosome 4 at 27 cM nearest markers D4S403 and D4S419 (LOD = 1.22, point-wise empirical p = .00973) with a support interval that extended from 7 – 43 cM. The third peak was found on chromosome 11 at 135 cM nearest marker D11S4126 (LOD = 1.11, point-wise empirical p = .01292) with a support interval that spanned 106 – 146 cM, and the fourth locus was found on chromosome 12 at 50 cM nearest markers D12S1640 and D12S345 (LOD = 1.51, point-wise empirical p = .00452) with a support interval that extended from 37 – 67 cM. Notably, the parallel relative pair analyses only found evidence of linkage to the peak on chromosome 2 at 123 cM, though this evidence was fairly weak (All pairs LOD = 1.21, point-wise empirical p=.00929).