A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence.
paper
Primary
Public
Unavailable
- Authors
- Bierut, Laura Jean; Rice, John P; Goate, Alison; Hinrichs, Anthony L; Saccone, Nancy L; Foroud, Tatiana; Edenberg, Howard J; Cloninger, C Robert; Begleiter, Henri; Conneally, P Michael; Crowe, Raymond R; Hesselbrock, Victor; Li, Ting-Kai; Nurnberger, John I; Porjesz, Bernice; Schuckit, Marc A; Reich, Theodore
- Year
- 2004
- Journal
- American journal of medical genetics. Part A
- PMID
- 14679582
- DOI
- 10.1002/ajmg.a.20329
Smoking is a highly heritable, addictive disorder that commonly co-occurs with alcohol dependence. The purpose of this study is to perform a genomic screen for habitual smoking and comorbid habitual smoking and alcohol dependence in families from the Collaborative Study on the Genetics of Alcoholism (COGA). Subjects were assessed using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) to evaluate alcohol dependence and habitual smoking (smoking one pack per day or more for at least 6 months). Sixty seven multi-generational families with 154 independent sibling pairs affected with habitual smoking were genotyped in a screening sample. Analyses on 79 multi-generational families with 173 independent sibling pairs were repeated in a replication sample. Sibpair analyses were performed using ASPEX. Four chromosomal regions in the screening sample had increased allele sharing among sibling pairs for habitual smoking with a LOD score greater than 1 (chromosomes 5, 9, 11, and 21). The highest LOD score was on chromosome 9 (LOD = 2.02; allele sharing 58.9%). Four chromosomal regions also had modest evidence for linkage to the comorbid phenotype habitual smoking and alcohol dependence (chromosomes 1, 2, 11, 15); and the strongest finding was on chromosome 2 (LOD = 3.30; allele sharing 69.1%). Previously identified areas (chromosomes 1 and 7) implicated in the development of alcohol dependence in this same data set did not provide evidence for linkage to habitual smoking in the screening sample. In the replication data set, there continued to be increased allele sharing near peaks identified in the screening sample on chromosomes 2 and 9, but the results were modest. An area on chromosome 7, approximately 60 cM from a location previously identified in linkage analysis with alcohol dependence, had increased allele sharing for the comorbid habitual smoking and alcohol dependence. These data provide evidence of specific genetic regions involved in the development of habitual smoking and not alcohol dependence. Conversely, genetic regions that influence the development of alcohol dependence do not appear to contribute to the development of habitual smoking. Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | — | 2021 | → |
| Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. | Cross SJ et al. | — | 2017 | → |
| Pharmacological Options for Smoking Cessation in Heavy-Drinking Smokers. | Yardley MM et al. | — | 2015 | → |
| Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. | Ma Y et al. | — | 2015 | → |
| Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation. | Li X et al. | — | 2014 | → |
| Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans. | Hulka LM et al. | — | 2014 | → |
| A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity. | Wen Y et al. | — | 2013 | → |
| Alcohol and tobacco use disorder comorbidity in young adults and the influence of romantic partner environments. | Meacham MC et al. | — | 2013 | → |
| Genetics of alcohol dependence and social work research: do they mix? | Hesselbrock MN et al. | — | 2013 | → |
| Unraveling the neurobiology of nicotine dependence using genetically engineered mice. | Stoker AK et al. | — | 2013 | → |
| Alcohol consumption as a risk factor for autoimmune thyroid disease: a prospective study. | Effraimidis G et al. | — | 2012 | → |
| Genetics of GABAergic signaling in nicotine and alcohol dependence. | Cui WY et al. | — | 2012 | → |
| Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study. | Gizer IR et al. | — | 2012 | → |
| Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. | Stoker AK et al. | — | 2012 | → |
| Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study. | Gizer IR et al. | — | 2011 | → |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | — | 2010 | → |
| EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study. | Ehlers CL et al. | — | 2010 | → |
| Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | Dick DM et al. | — | 2010 | → |
| Meta-analysis of 15 genome-wide linkage scans of smoking behavior. | Han S et al. | — | 2010 | → |
| Obesity, smoking, and frontal brain dysfunction. | Bauer L et al. | — | 2010 | → |
| Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. | Ma JZ et al. | — | 2010 | → |
| Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. | Uhl GR et al. | — | 2009 | → |
| Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. | Li MD et al. | — | 2009 | → |
| Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. | Yue J et al. | — | 2009 | → |
| Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. | Pergadia ML et al. | — | 2009 | → |
| Genome-wide and candidate gene association study of cigarette smoking behaviors. | Caporaso N et al. | — | 2009 | → |
| New insights into the genetics of addiction. | Li MD et al. | — | 2009 | → |
| Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X et al. | — | 2009 | → |
| Addiction Reviews. Preface. | Uhl GR | — | 2008 | → |
| A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. | Ghosh S et al. | — | 2008 | → |
| A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. | Grucza RA et al. | — | 2008 | → |
| Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. | Sherva R et al. | — | 2008 | → |
| Genes and cigarette smoking. | Munafò MR et al. | — | 2008 | → |
| Genetics of nicotine dependence and pharmacotherapy. | Lessov-Schlaggar CN et al. | — | 2008 | → |
| Genetic variation in the dopamine pathway and smoking cessation. | David SP et al. | — | 2008 | → |
| Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. | Li MD et al. | — | 2008 | → |
| Genomewide linkage survey of nicotine dependence phenotypes. | Sullivan PF et al. | — | 2008 | → |
| Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. | Nielsen DA et al. | — | 2008 | → |
| "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. | Uhl GR et al. | — | 2008 | → |
| Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses. | Li MD | — | 2008 | → |
| Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. | Paletzki RF et al. | — | 2008 | → |
| Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background. | Loukola A et al. | — | 2008 | → |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | — | 2008 | → |
| Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. | Uhl GR et al. | — | 2008 | → |
| Ordered subsets linkage analysis of antisocial behavior in substance use disorder among participants in the Collaborative Study on the Genetics of Alcoholism. | Jacobson KC et al. | — | 2008 | → |
| Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype? | Meyerhoff DJ et al. | — | 2008 | → |
| Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. | Sartor CE et al. | — | 2008 | → |
| Variants in nicotinic receptors and risk for nicotine dependence. | Bierut LJ et al. | — | 2008 | → |
| A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. | Hopfer CJ et al. | — | 2007 | → |
| Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. | Beuten J et al. | — | 2007 | → |
| Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. | Saccone SF et al. | — | 2007 | → |
| Genetics and smoking behavior. | Schnoll RA et al. | — | 2007 | → |
| Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus. | Gelernter J et al. | — | 2007 | → |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | — | 2007 | → |
| Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. | Li MD et al. | — | 2007 | → |
| Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. | Uhl GR et al. | — | 2007 | → |
| Novel genes identified in a high-density genome wide association study for nicotine dependence. | Bierut LJ et al. | — | 2007 | → |
| Overview of the pharmacogenomics of cigarette smoking. | Ho MK et al. | — | 2007 | → |
| Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. | Volkow ND et al. | — | 2007 | → |
| Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions. | Sun D et al. | — | 2007 | → |
| RhoA, encoding a Rho GTPase, is associated with smoking initiation. | Chen X et al. | — | 2007 | → |
| The biological bases of nicotine and alcohol co-addiction. | Li TK et al. | — | 2007 | → |
| A genome-wide screen for nicotine dependence susceptibility loci. | Swan GE et al. | — | 2006 | → |
| A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. | Li MD et al. | — | 2006 | → |
| A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. | Morley KI et al. | — | 2006 | → |
| Barriers and solutions to addressing tobacco dependence in addiction treatment programs. | Ziedonis DM et al. | — | 2006 | → |
| Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, cross-tolerance, and genetic factors. | Funk D et al. | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| Cognitive traits link to human chromosomal regions. | Buyske S et al. | — | 2006 | → |
| Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. | Grucza RA et al. | — | 2006 | → |
| Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. | Lou XY et al. | — | 2006 | → |
| Genetics and alcoholism: how close are we to potential clinical applications? | Quickfall J et al. | — | 2006 | → |
| Genome-wide linkage scan to identify Loci for age at first cigarette in Dutch sibling pairs. | Vink JM et al. | — | 2006 | → |
| Genomic screen for loci associated with tobacco usage in Mission Indians. | Ehlers CL et al. | — | 2006 | → |
| Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. | Gelernter J et al. | — | 2006 | → |
| Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake. | Lê AD et al. | — | 2006 | → |
| Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. | Yu Y et al. | — | 2006 | → |
| NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. | Ishiguro H et al. | — | 2006 | → |
| Symbiotic relationship of pharmacogenetics and drugs of abuse. | Rutter JL | — | 2006 | → |
| The genetics of nicotine dependence. | Li MD | — | 2006 | → |
| Alcohol and gene interactions. | Whitfield JB | — | 2005 | → |
| Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. | Schwab SG et al. | — | 2005 | → |
| COGA phenotypes and linkages on chromosome 2. | Wiener HW et al. | — | 2005 | → |
| Heritability of smoking initiation and nicotine dependence. | Vink JM et al. | — | 2005 | → |
| Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. | Beuten J et al. | — | 2005 | → |
| Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. | Beuten J et al. | — | 2005 | → |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | — | 2004 | → |
| Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. | Vink JM et al. | — | 2004 | → |
| Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. | Gelernter J et al. | — | 2004 | → |
| Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation. | Swan GE et al. | — | 2003 | → |