Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?
paper
Cited
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Unavailable
- Authors
- Young, Susan E; Rhee, Soo Hyun; Stallings, Michael C; Corley, Robin P; Hewitt, John K
- Year
- 2006
- Journal
- Behavior genetics
- PMID
- 16619135
- DOI
- 10.1007/s10519-006-9066-7
Are genetic and environmental risks for adolescent substance use specific to individual substances or general across substance classes? We examined this question in 645 monozygotic twin pairs, 702 dizygotic twin pairs, 429 biological sibling pairs, and 96 adoptive (biologically unrelated) sibling pairs ascertained from community-based samples, and ranging in age from 12 to 18 years. Substance use patterns and symptoms were assessed using structured psychiatric interviews. Biometrical model fitting was carried out using age- and sex-specific thresholds for (a) repeated use and (b) problem use, defined as one or more DSM-IV symptoms of abuse or dependence. We hypothesized that problem use would be more heritable than use in adolescence, and that both genetic and environmental risks underlying tobacco, alcohol, and marijuana use and problem use would be significantly correlated. Results of univariate analyses suggested significant heritable factors for use and problem use for all substances with the exception of alcohol use. Shared environmental factors were important in all cases and special twin environmental factors were significant for tobacco use, tobacco problem use, and alcohol use. Multivariate analyses yielded significant genetic correlations between each of the substances (for both levels studied), and significant shared environmental correlations among use variables only. Our results suggest that tobacco, alcohol, and marijuana problem use are mediated by common genetic influences, but shared environmental influences may be more substance-specific for problem use.
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|---|---|---|---|---|
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| Genetic Architecture and Risk Profile of Alcohol-Related Diseases | Ala-Mutka E et al. | — | 2025 | — |
| Phasic dopamine release in two different rat models of attention-deficit/hyperactivity disorder: Spontaneously hypertensive rats (SHR) versus Lphn3 knockout rats. | Sable HJK et al. | — | 2025 | → |
| Cannabis reduction among adolescents as spillover from successful tobacco control. | Miech R et al. | — | 2024 | → |
| Evidence for sex differences in the impact of cytochrome P450 genotypes on early subjective effects of cannabis. | Davis CN et al. | — | 2024 | → |
| Generalized genetic liability to substance use disorders. | Miller AP et al. | — | 2024 | → |
| Anxiety-specific associations with substance use: Evidence of a protective factor in adolescence and a risk factor in adulthood. | Rieselbach MM et al. | — | 2023 | → |
| Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study. | Gresko SA et al. | — | 2022 | → |
| Child Maltreatment and Substance Use: A Behavior Genetic Analysis. | Azimi AM et al. | — | 2022 | → |
| Alcohol attention bias in 14-16 year old adolescents: an eye tracking study. | McGivern C et al. | — | 2021 | → |
| Genetics of substance use disorders: a review. | Deak JD et al. | — | 2021 | → |
| The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry. | Brick LA et al. | — | 2021 | → |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction | Sun J et al. | — | 2020 | → |
| Childhood language development and later alcohol use behaviors. | Woodward KE et al. | — | 2019 | → |
| Depressive symptoms, sexual activity, and substance use among adolescents in Kampala, Uganda. | Henry MB et al. | — | 2019 | → |
| Family Aggregation of Substance Use Disorders: Substance Specific, Nonspecific, and Intrafamilial Sources of Risk. | Farmer RF et al. | — | 2019 | → |
| Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use. | Allegrini AG et al. | — | 2019 | → |
| Personal and Socioeconomic Determinants in Medication-assisted Treatment of Opioid Use Disorder in Adolescents and Young Adults. | Grubb LK | — | 2019 | → |
| The Relationship Between Tobacco and Cannabis Use: A Review. | Lemyre A et al. | — | 2019 | → |
| Tobacco and cannabis use in college students are predicted by sex-dimorphic interactions between MAOA genotype and child abuse. | Fite PJ et al. | — | 2019 | → |
| Criterion Validity and Utility of the General Factor of Psychopathology in Childhood: Predictive Associations With Independently Measured Severe Adverse Mental Health Outcomes in Adolescence. | Pettersson E et al. | — | 2018 | → |
| The gene-environmental architecture of the development of adolescent substance use. | Vitaro F et al. | — | 2018 | → |
| The genetic and environmental architecture of substance use development from early adolescence into young adulthood: a longitudinal twin study of comorbidity of alcohol, tobacco and illicit drug use. | Waaktaar T et al. | — | 2018 | → |
| The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design. | Iacono WG et al. | — | 2018 | → |
| Young adults report increased pleasure from smoking cigarettes when drinking alcohol but not when using marijuana. | Gubner NR et al. | — | 2018 | → |
| Familial and Special Twin Influences on Cigarette Use Initiation. | Bares CB et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder. | Brook JS et al. | — | 2016 | → |
| Cooccurring Psychiatric and Substance Use Disorders. | Robinson ZD et al. | — | 2016 | → |
| Mostly Smokers: Identifying Subtypes of Emerging Adult Substance Users. | Tzilos GK et al. | — | 2016 | → |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | — | 2016 | → |
| Racial-ethnic differences in sexual risk behaviors: The role of substance use. | Miller PK et al. | — | 2016 | → |
| Sex differences in genetic and environmental contributions to alcohol consumption from early adolescence to young adulthood. | Seglem KB et al. | — | 2016 | → |
| The genetic relationship between cannabis and tobacco cigarette use in European- and African-American female twins and siblings. | Agrawal A et al. | — | 2016 | → |
| The risk of offspring developing substance use disorders when exposed to one versus two parent(s) with alcohol use disorder: A nationwide, register-based cohort study. | Mellentin AI et al. | — | 2016 | → |
| Tobacco Use Among Siblings of Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study. | Buchbinder D et al. | — | 2016 | → |
| Are genetic variants for tobacco smoking associated with cannabis involvement? | Agrawal A et al. | — | 2015 | → |
| Assessing the overlap between tobacco and marijuana: Trends in patterns of co-use of tobacco and marijuana in adults from 2003-2012. | Schauer GL et al. | — | 2015 | → |
| Association of substance dependence phenotypes in the COGA sample. | Wetherill L et al. | — | 2015 | → |
| DAT1 and Alcohol Use: Differential Responses to Life Stress during Adolescence. | Stogner JM | — | 2015 | → |
| Disruptive behavior disorders and indicators of disinhibition in adolescents: The BRIEF-SR, anti-saccade task, and D-KEFS color-word interference test. | Long EC et al. | — | 2015 | → |
| Genetic and environmental influences on adolescents' smoking involvement: a multi-informant twin study. | Seglem KB et al. | — | 2015 | → |
| Perceptions of Family Alcohol Use in a Young Adult Sample. | Serafini KA et al. | — | 2015 | → |
| The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders. | Grant JD et al. | — | 2015 | → |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | — | 2014 | → |
| Drug use, abuse, and dependence and the persistence of nicotine dependence. | Goodwin RD et al. | — | 2014 | → |
| Externalizing Disorders and Environmental Risk: Mechanisms of Gene-Environment Interplay and Strategies for Intervention. | Samek DR et al. | — | 2014 | → |
| Gender and racial/ethnic differences in patterns of adolescent alcohol use and associations with adolescent and adult illicit drug use. | Khan MR et al. | — | 2014 | → |
| General and substance-specific predictors of young adult nicotine dependence, alcohol use disorder, and problem behavior: replication in two samples. | Bailey JA et al. | — | 2014 | → |
| Have the genetics of cannabis involvement gone to pot? | Agrawal A et al. | — | 2014 | → |
| Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? | Maciejewski DF et al. | — | 2014 | → |
| Polygenic risk scores for smoking: predictors for alcohol and cannabis use? | Vink JM et al. | — | 2014 | → |
| Psychiatric, psychosocial, and physical health correlates of co-occurring cannabis use disorders and nicotine dependence. | Peters EN et al. | — | 2014 | → |
| Sexual risk behavior in young adulthood: broadening the scope beyond early sexual initiation. | Epstein M et al. | — | 2014 | → |
| Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. | Carmiol N et al. | — | 2014 | → |
| The adolescent origins of substance use disorders: a behavioral genetic perspective. | McGue M et al. | — | 2014 | → |
| Youth tobacco use type and associations with substance use disorders. | Cavazos-Rehg PA et al. | — | 2014 | → |
| Assessing tobacco dependence among cannabis users smoking cigarettes. | Flatz A et al. | — | 2013 | → |
| Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders. | Euser AS et al. | — | 2013 | → |
| Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring. | Hicks BM et al. | — | 2013 | → |
| Science-based prevention through communities that care: a model of social work practice for public health. | Haggerty KP et al. | — | 2013 | → |
| Stability and change of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis DSM-IV dependence symptoms. | Palmer RH et al. | — | 2013 | → |
| The effect of general and drug-specific family environments on comorbid and drug-specific problem behavior: a longitudinal examination. | Epstein M et al. | — | 2013 | → |
| Clinical correlates of co-occurring cannabis and tobacco use: a systematic review. | Peters EN et al. | — | 2012 | → |
| Developmental trajectories of substance use from early adolescence to young adulthood: gender and racial/ethnic differences. | Chen P et al. | — | 2012 | → |
| Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH et al. | — | 2012 | → |
| Genetic and environmental etiologies of reading difficulties: DeFries-Fulker analysis of reading performance data from twin pairs and their nontwin siblings. | Astrom RL et al. | — | 2012 | → |
| Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. | Korhonen T et al. | — | 2012 | → |
| Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms. | Palmer RH et al. | — | 2012 | → |
| Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study. | Gizer IR et al. | — | 2012 | → |
| Levels of aggressiveness are higher among alcohol-related suicides: results from a psychological autopsy study. | Chachamovich E et al. | — | 2012 | → |
| Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes. | Chen LS et al. | — | 2012 | → |
| Shared environmental contributions to substance use. | Baker JH et al. | — | 2012 | → |
| Subjective effects for alcohol, tobacco, and marijuana association with cross-drug outcomes. | Zeiger JS et al. | — | 2012 | → |
| The co-occurring use and misuse of cannabis and tobacco: a review. | Agrawal A et al. | — | 2012 | → |
| The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. | Zhang T et al. | — | 2012 | → |
| Age moderates non-genetic influences on the initiation of cannabis use: a twin-sibling study in Dutch adolescents and young adults. | Distel MA et al. | — | 2011 | → |
| Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. | Ho BC et al. | — | 2011 | → |
| CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. | Hoft NR et al. | — | 2011 | → |
| Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use. | Haberstick BC et al. | — | 2011 | → |
| DeFries-Fulker analysis of longitudinal reading performance data from twin pairs ascertained for reading difficulties and from their nontwin siblings. | Astrom RL et al. | — | 2011 | → |
| Deviant socialization mediates transmissible and contextual risk on cannabis use disorder development: a prospective study. | Tarter RE et al. | — | 2011 | → |
| Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. | Hendershot CS et al. | — | 2011 | → |
| Reduced cortical gray matter volume in male adolescents with substance and conduct problems. | Dalwani M et al. | — | 2011 | → |
| Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood. | Baker JH et al. | — | 2011 | → |
| Strategies for characterizing complex phenotypes and environments: general and specific family environmental predictors of young adult tobacco dependence, alcohol use disorder, and co-occurring problems. | Bailey JA et al. | — | 2011 | → |
| Association of CHRN genes with "dizziness" to tobacco. | Ehringer MA et al. | — | 2010 | → |
| Common genetic contributions to alcohol and cannabis use and dependence symptomatology. | Sartor CE et al. | — | 2010 | → |
| Eating disorder symptomatology and substance use disorders: prevalence and shared risk in a population based twin sample. | Baker JH et al. | — | 2010 | → |
| Genetically informative research on adolescent substance use: methods, findings, and challenges. | Lynskey MT et al. | — | 2010 | → |
| Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. | Verweij KJ et al. | — | 2010 | → |
| Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins. | Agrawal A et al. | — | 2010 | → |
| Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. | Young SE et al. | — | 2009 | → |
| Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. | Onaivi ES | — | 2009 | → |
| Common genetic influences on the timing of first use for alcohol, cigarettes, and cannabis in young African-American women. | Sartor CE et al. | — | 2009 | → |
| Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk. | Palmer RH et al. | — | 2009 | → |
| Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. | Agrawal A et al. | — | 2009 | → |
| Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability. | Button TM et al. | — | 2009 | → |
| Prediction of cannabis use disorder between boyhood and young adulthood: clarifying the phenotype and environtype. | Kirisci L et al. | — | 2009 | → |
| Predictors of problem drinking in adolescence and young adulthood. A longitudinal twin-family study. | Poelen EA et al. | — | 2009 | → |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | — | 2008 | → |
| Association of candidate genes with antisocial drug dependence in adolescents. | Corley RP et al. | — | 2008 | → |
| Autosomal linkage analysis for cannabis use behaviors in Australian adults. | Agrawal A et al. | — | 2008 | → |
| Early cannabis use and DSM-IV nicotine dependence: a twin study. | Agrawal A et al. | — | 2008 | → |
| Gene-environment correlation and interaction in peer effects on adolescent alcohol and tobacco use. | Harden KP et al. | — | 2008 | → |
| Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. | Xian H et al. | — | 2008 | → |
| Neurobiology of addiction. An integrative review. | Goodman A | — | 2008 | → |
| Parental supervision and alcohol use in adolescence: developmentally specific interactions. | Clark DB et al. | — | 2008 | → |
| Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study. | Sartor CE et al. | — | 2008 | → |
| The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. | Schlaepfer IR et al. | — | 2008 | → |
| The genetic components of alcohol and nicotine co-addiction: from genes to behavior. | Schlaepfer IR et al. | — | 2008 | → |
| Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. | Ehringer MA et al. | — | 2007 | → |
| Substance use risk across three generations: the roles of parent discipline practices and inhibitory control. | Pears K et al. | — | 2007 | → |
| Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. | Hopfer CJ et al. | — | 2006 | → |
| Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue. | Prescott CA et al. | — | 2006 | → |
| The developmental behavior genetics of drug involvement: overview and comments. | Zucker RA | — | 2006 | → |