'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
paper
Cited
Public
Unavailable
- Authors
- Smith, George Davey; Ebrahim, Shah
- Year
- 2003
- Journal
- International journal of epidemiology
- PMID
- 12689998
- DOI
- 10.1093/ije/dyg070
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization-the random assortment of genes from parents to offspring that occurs during gamete formation and conception-provides one method for assessing the causal nature of some environmental exposures. The association between a disease and a polymorphism that mimics the biological link between a proposed exposure and disease is not generally susceptible to the reverse causation or confounding that may distort interpretations of conventional observational studies. Several examples where the phenotypic effects of polymorphisms are well documented provide encouraging evidence of the explanatory power of Mendelian randomization and are described. The limitations of the approach include confounding by polymorphisms in linkage disequilibrium with the polymorphism under study, that polymorphisms may have several phenotypic effects associated with disease, the lack of suitable polymorphisms for studying modifiable exposures of interest, and canalization-the buffering of the effects of genetic variation during development. Nevertheless, Mendelian randomization provides new opportunities to test causality and demonstrates how investment in the human genome project may contribute to understanding and preventing the adverse effects on human health of modifiable exposures.
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| Genetic insights into the risk of frailty on metabolic syndrome and its components: Bidirectional Mendelian randomization study. | Zhang Z et al. | β | 2025 | β |
| Genetic insights into the shared molecular mechanisms of Crohn's disease and breast cancer: a Mendelian randomization and deep learning approach. | Wang ZZ et al. | β | 2025 | β |
| Genetic liability to depression and cerebral small vessel disease: A mendelian randomization study. | Wang M et al. | β | 2025 | β |
| Genetic liability to gut microbiota and inflammatory cytokines in relation to systemic lupus erythematosus risk: a multi-omics study. | Lu RL et al. | β | 2025 | β |
| Genetic prediction of immune cells, inflammatory proteins, and metabolite-mediated association between gut microbiota and COPD: a Mendelian randomization study. | Chen G et al. | β | 2025 | β |
| Genetic prediction of the casual relationship between micronutrients and ER+ breast cancer: a Mendelian randomized study. | Fu WD et al. | β | 2025 | β |
| Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries. | Urbut SM et al. | β | 2025 | β |
| Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study. | Liu H et al. | β | 2025 | β |
| Genome-wide association analysis identified inflammatory mechanisms mediating the effects of lipid metabolism on endometrial carcinoma in situ. | Lang T et al. | β | 2025 | β |
| Genome-wide association study of REM sleep behavior disorder in Parkinson's disease. | Sosero YL et al. | β | 2025 | β |
| Genomics of chronic dry cough unravels neurological pathways. | Coley K et al. | β | 2025 | β |
| Great debate: Plasma triglycerides are an important causal factor and therapeutic target for atherosclerotic cardiovascular disease. | BorΓ©n J et al. | β | 2025 | β |
| Gut Microbiota and Gastrointestinal Polyps: Unveiling the Causal Connection. | Karakan T | β | 2025 | β |
| Gut Microbiota as Targets for Preventing Ovalbumin-Induced Food Allergy. | Shi X et al. | β | 2025 | β |
| Gut microbiota, inflammatory cytokines and gastro-esophageal reflux disease: A Mendelian randomization analysis. | Wang Q et al. | β | 2025 | β |
| Gut microbiota, inflammatory proteins and bone mineral density in different age groups: A Mendelian randomization study. | Hong Y et al. | β | 2025 | β |
| Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study. | Zheng L et al. | β | 2025 | β |
| Gut microbiota-mediated targeting of EHMT2 in individuals of European ancestry: A novel therapeutic approach for Alzheimer's disease. | Yan Y et al. | β | 2025 | β |
| Gut microbiota, plasma metabolites, and venous thromboembolism: a Mendelian randomization study. | Cheng PF et al. | β | 2025 | β |
| Harnessing nutrients and natural products for sustainable drug development against aging. | Ding F et al. | β | 2025 | β |
| Helicobacter Pylori Infection is Not Causally Associated with Colorectal Cancer: A Two-Sample Mendelian Randomization Study. | Wang S et al. | β | 2025 | β |
| High BMI and smoking jointly cause COPD: a Mendelian randomisation study. | Mikkelsen H et al. | β | 2025 | β |
| High salt diet causally increases metabolic dysfunction-associated steatotic liver disease risk: A bidirectional mendelian randomization study. | Liu Q et al. | β | 2025 | β |
| How eHealth use and cancer information-seeking influence older adults' acceptance of genetic testing: Mediating roles of PIGI and cancer worry. | Zhu Y et al. | β | 2025 | β |
| Hub Genes PRPF19 and PPIB: Molecular Pathways and Potential Biomarkers in COPD. | Zhao J et al. | β | 2025 | β |
| Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000-2025). | Chen Q et al. | β | 2025 | β |
| Hypertension precision medicine: the promise and pitfalls of pharmacogenomics. | Le NN et al. | β | 2025 | β |
| Hypertriglyceridemia (>150mg/dL) as a marker of cardiovascular risk. | LΓ³pez-Miranda J | β | 2025 | β |
| Identification and Inference with Invalid Instruments. | Kang H et al. | β | 2025 | β |
| Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single-Cell Transcriptomics. | Song C et al. | β | 2025 | β |
| Identification of exosome-related genes in Alzheimer's disease: Evidence from transcriptomic and Mendelian randomization analyses. | Jiang X et al. | β | 2025 | β |
| Identification of genetically-supported new drug targets for osteomyelitis based on druggable genomes. | Yao R et al. | β | 2025 | β |
| Identification of novel biomarkers and drug targets for frailty-related skeletal muscle aging: a multi-omics study. | Wang Q et al. | β | 2025 | β |
| Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis. | Huoshen W et al. | β | 2025 | β |
| Identification of potential causal genes and drug targets in pulmonary hypertension based on transcriptomic analysis and Mendelian randomization. | Liu C et al. | β | 2025 | β |
| Identification of potential therapeutic targets for problematic alcohol use using multi-omics data. | Lee DJ et al. | β | 2025 | β |
| Identification of shared diagnostic biomarkers and potential co-morbidity mechanisms between primary Sjogren's syndrome and chronic kidney disease. | Jiang S et al. | β | 2025 | β |
| Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis. | Lei S et al. | β | 2025 | β |
| Identifying diagnostic biomarkers for glaucoma based on transcriptome combined with Mendelian randomization. | Lin X et al. | β | 2025 | β |
| Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis. | Lei S et al. | β | 2025 | β |
| Identifying therapeutic targets for allergic asthma through atopic dermatitis-associated genetic mechanisms. | Pu Y et al. | β | 2025 | β |
| IL7R<sup>+</sup> T Cell-Macrophage Crosstalk Links Asthma to Alzheimer's Pathogenesis: Integrating Mendelian Randomization and CellChat Analysis. | Yang J et al. | β | 2025 | β |
| Immune cell-based transcriptomic Mendelian randomization and colocalization study on type 1 diabetes. | Sklar J et al. | β | 2025 | β |
| Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study. | Chen JH et al. | β | 2025 | β |
| Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study. | He L et al. | β | 2025 | β |
| Immunological Insights into the Causal Link Between Arthritis, Osteoarthritis, and Frailty: An Integrated Analytical Study. | Wen S et al. | β | 2025 | β |
| Impact of COVID-19 on neoadjuvant chemotherapy efficacy in patients with breast cancer: An ambidirectional cohort study and mendelian randomization analysis. | Wang Y et al. | β | 2025 | β |
| Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study. | Xiang L et al. | β | 2025 | β |
| Impact of Gut Microbiota and Inflammatory Cytokines on Immune Thrombocytopenia. | Wang JG et al. | β | 2025 | β |
| <i>MTHFR</i> Polymorphisms, Homocysteine Elevation, and Ischemic Stroke Susceptibility in East Asian and European Populations. | Wang M et al. | β | 2025 | β |
| Insomnia Proven to be Associated With Prostate Cancer: A Genetic Correlation Study Incorporating Lifestyle Factors. | Chen X et al. | β | 2025 | β |
| Instrumental Variable Methods to Target Hypothetical Estimands With Longitudinal Repeated Measures Data: Application to the STEP 1 Trial. | Bowden J et al. | β | 2025 | β |
| Integrated trajectories of systolic and diastolic function differentially associate with risk for heart failure with preserved and reduced ejection fraction and proteomic profiles. | Reimer Jensen AM et al. | β | 2025 | β |
| Integrating differential gene expression and Mendelian randomization analyses reveal novel gene for prognosis, immune response, and drug sensitivity in lung cancer. | Li M et al. | β | 2025 | β |
| Integrating Genetic and Single-Cell Genomic Data to Reveal Brain Cell-Specific Regulation of Attention-Deficit/Hyperactivity Disorder Risk in the Prefrontal Cortex. | Gui J et al. | β | 2025 | β |
| Integrating Mendelian randomization and literature-mined evidence for breast cancer risk factors. | Vabistsevits M et al. | β | 2025 | β |
| Integrating Single-Cell Transcriptome-Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune-Related Drug Targets for Cancers. | Zheng J et al. | β | 2025 | β |
| Integrating Transcriptomics and Machine Learning to Uncover the FLI1-PARP14-Immune Axis in Ulcerative Colitis Activity and Pathogenesis. | Zheng Z et al. | β | 2025 | β |
| Integration of summary data from GWAS and eQTLs studies predicts causality of S1PR1 and breast cancer. | Shi H et al. | β | 2025 | β |
| Integrative analysis identifies novel proteins associated with chronic kidney disease in participants with abnormal glucose metabolism. | Li N et al. | β | 2025 | β |
| Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics. | Feng S et al. | β | 2025 | β |
| Integrative genomics and functional immunology reveal Clostridia species as modulators of neuroinflammation in amyotrophic lateral sclerosis. | Wang S et al. | β | 2025 | β |
| Integrative Mendelian randomization and spatial transcriptomics analysis reveals causal links between plasma lipidome and non-small cell lung cancer. | Zhang B et al. | β | 2025 | β |
| Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics. | Xu K et al. | β | 2025 | β |
| Interference between rheumatoid arthritis and autoimmune thyroid diseases: A bidirectional Mendelian randomization. | Yin Y et al. | β | 2025 | β |
| Investigating Causal Associations of Diet Compositions with the Risk of Lung Cancer. | Wang S et al. | β | 2025 | β |
| Investigating causal effects of income on health using two-sample Mendelian randomisation. | IgelstrΓΆm E et al. | β | 2025 | β |
| Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study. | Lv R et al. | β | 2025 | β |
| Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study. | Zhang H et al. | β | 2025 | β |
| Investigating the Causal Association Between <i>Helicobacter pylori</i> Infection and Diabetic Nephropathy: A Two-Sample Mendelian Randomization Study. | Yu L et al. | β | 2025 | β |
| Investigating the causal links among gut microbiome features, inflammation-related proteins, and diverticular disease: Insights from a mediation Mendelian randomization study. | Zhou J et al. | β | 2025 | β |
| Investigating the controversy surrounding statin therapy and Achilles tendinopathy using Mendelian randomization analysis. | Zhou J et al. | β | 2025 | β |
| Investigating the Genetic Links Between Immune Cell Profiles and Bladder Cancer: A Multidisciplinary Bioinformatics Approach. | Zhang J et al. | β | 2025 | β |
| Investigating the non-linear association between sleep duration and type 2 diabetes: conventional and Mendelian randomization analyses from the UK Biobank. | Kuroda H et al. | β | 2025 | β |
| Investigating the relationship between breast cancer risk factors and an AI-generated mammographic texture feature in the Nurses' Health Study II. | Wu X et al. | β | 2025 | β |
| Investigating the Relationship Between Maternal Smoking During Pregnancy and Offspring Handedness: Extending the Proxy Gene-by-Environment Mendelian Randomization Study Design to Include Polygenic Risk Scores. | Crick DCP et al. | β | 2025 | β |
| Investigation of brain structures and potential mechanisms associated with ADHD: Insights from Mendelian randomization and genetic analysis. | Hu X et al. | β | 2025 | β |
| Is early-life obesity associated with kidney cancer in adulthood?-insights from genetic studies. | Yang S et al. | β | 2025 | β |
| Job involvement in heavy manual or physical work associated with epigenetic age: A Mendelian randomization study. | Sun X | β | 2025 | β |
| Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes. | Zhu Z et al. | β | 2025 | β |
| KIAA0319 modulates Alzheimer's disease risk through PMM2 regulation: Evidence from integrated pQTL-mediation and transcriptomic analyses. | Wen P et al. | β | 2025 | β |
| Knowledge of the genetics of human pain gained over the last decade from next-generation sequencing. | Kringel D et al. | β | 2025 | β |
| L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validation. | Wang H et al. | β | 2025 | β |
| Lack of evidence for obesity paradox in patients with cardiovascular disease: A UK BioBank cohort study. | Yu W et al. | β | 2025 | β |
| Large-scale genetic mapping for human brain asymmetry. | Sha Z et al. | β | 2025 | β |
| Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors. | Ao L et al. | β | 2025 | β |
| Lifelong impacts of puberty timing on human plasma metabolic profiles: A metabolome-wide Mendelian randomization study. | Li Z et al. | β | 2025 | β |
| Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study. | Chen JL et al. | β | 2025 | β |
| Lipid Transporter ABCA1 in Diabetic Polyneuropathy: Potential Mediation by Circulating Metabolites. | Cao Y et al. | β | 2025 | β |
| Longitudinal change and causal relationship between gut microbiota and gestational diabetes mellitus. | Wu X et al. | β | 2025 | β |
| Long-term physical health conditions and youth anxiety and depression: Is there a causal link? | Shakeshaft A et al. | β | 2025 | β |
| Machine learning approach on plasma proteomics identifies signatures associated with obesity in the KORA FF4 cohort. | Niu J et al. | β | 2025 | β |
| Magnetic resonance imaging quantifies causal body compartment effects on metabolic traits via immune phenotypes-a Mendelian randomisation study. | Zhang D et al. | β | 2025 | β |
| Measures of General Intelligence and Risk for Alcohol Use Disorder. | Capusan AJ et al. | β | 2025 | β |
| Mediating effects of gastroesophageal reflux disease and smoking behavior on the relationship between depression and chronic obstructive pulmonary disease: Trans-ethnic Mendelian randomization study. | Cheng Z et al. | β | 2025 | β |
| Mediating factors in the association between educational attainment and stroke: A mendelian randomization study. | Xu N et al. | β | 2025 | β |
| Mediating role of blood metabolites in the relationship between immune cell traits and sepsis: a Mendelian randomization and mediation analysis. | Liu Y et al. | β | 2025 | β |
| Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis. | Wu L et al. | β | 2025 | β |
| Mediators of the association between nut consumption and cardiovascular diseases: a two-step mendelian randomization study. | Wang R et al. | β | 2025 | β |
| Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions. | de Ruiter SC et al. | β | 2025 | β |
| Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer. | Wang H et al. | β | 2025 | β |
| Mendelian randomization analysis: investigating the causal association between apoptotic proteins and diabetes. | Zhou E et al. | β | 2025 | β |
| Mendelian randomization analysis of female reproductive factors on osteoarthritis. | Pang L et al. | β | 2025 | β |
| Mendelian randomization analysis of smoking, BMI, and nonalcoholic fatty liver disease in European descent populations. | Ma L et al. | β | 2025 | β |
| Mendelian randomization analysis of the causal association between metabolites and skin cancer. | Wang D et al. | β | 2025 | β |
| Mendelian randomization analysis provides insights into the relationship between inflammatory bowel disease and skin cancer. | Rashid S et al. | β | 2025 | β |
| Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis. | Liu B et al. | β | 2025 | β |
| Mendelian Randomization Analysis Reveals the Causal Relationships Between Autoimmune Diseases and Idiopathic Thrombocytopenic Purpura and the Mediating Role of Immune Cells. | Yan K et al. | β | 2025 | β |
| Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer. | Lin J et al. | β | 2025 | β |
| Mendelian Randomization and Colocalization Analysis Reveal New Drug Targets for Oral Ulcer: A Mendelian Randomization Analysis. | Zhang X et al. | β | 2025 | β |
| Mendelian Randomization and Infection: Pitfalls and Promises. | Hamilton F et al. | β | 2025 | β |
| Mendelian randomization and mediation analysis reveal the role of immune cells in the pathways between inflammatory factors and glioblastoma. | Xu R et al. | β | 2025 | β |
| Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer. | Sicheng Z et al. | β | 2025 | β |
| Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer. | Du W et al. | β | 2025 | β |
| Mendelian Randomization Evidence for Relationship and Mediation of Educational Attainment on Chronic Obstructive Pulmonary Disease. | Yang X et al. | β | 2025 | β |
| Mendelian randomization identifies genetically predicted calorie dietary preference as causal risk factors for cancer. | Zhang K et al. | β | 2025 | β |
| Mendelian randomization in cancer research: opportunities and challenges. | Tang M et al. | β | 2025 | β |
| Mendelian Randomization in Eye Research: Powerful, but Prone to Misuse. | Ying GS et al. | β | 2025 | β |
| Mendelian randomization in SLEEP: avoiding pitfalls with MR-SLEEP guidelines. | Evans DS et al. | β | 2025 | β |
| Mendelian randomization in the discovery of risk factors for autoimmune skin diseases: a bibliometric and visualized analysis. | Mao C et al. | β | 2025 | β |
| Mendelian randomization of serum micronutrients and osteoarthritis risk: focus on zinc. | Zeng W et al. | β | 2025 | β |
| Mendelian randomization reveals the causal links between miRNAs and rheumatoid arthritis. | Wei Z et al. | β | 2025 | β |
| Mendelian Randomization Studies: Opening a New Window in the Study of Metabolic Diseases and Chronic Kidney Disease. | Liang N et al. | β | 2025 | β |
| Mendelian randomization study investigating the relationship between nutrients and polycystic ovary syndrome. | Zhang Y et al. | β | 2025 | β |
| Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes. | Yao X et al. | β | 2025 | β |
| Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis. | Zuo GS et al. | β | 2025 | β |
| Mendelian randomization suggests a causal relationship between cerebrospinal fluid metabolites and intracranial aneurysms. | Yuan H et al. | β | 2025 | β |
| Mendelian randomization underscores the importance of clinical nursing in mitigating anxiety and panic attack risks among low-educated populations. | Li H et al. | β | 2025 | β |
| Metabolic syndrome and cancer risk: a two-sample Mendelian randomization study of European ancestry. | Zhou L et al. | β | 2025 | β |
| Micronutrients and polycystic ovary syndrome in the IEU OpenGWAS project: a two-Sample unidirectional Mendelian randomization analysis. | Bai Y et al. | β | 2025 | β |
| Modeling the Impact of Vaping: What We Need to Know and Which Methods to Use. | Shahab L | β | 2025 | β |
| Modifiable Dietary Habits, Inflammatory Mediation, and Senile Cataract: Unraveling Causality via Mendelian Randomization. | Deng J et al. | β | 2025 | β |
| Mood instability and 22 gastrointestinal disorders: investigating the causal relationships and the mediating factors by Mendelian randomization analysis. | Yan F et al. | β | 2025 | β |
| Morbidity-bridging metabolic pathways: linking early cardiovascular disease risk and depression symptoms using a multi-modal approach. | Koloi A et al. | β | 2025 | β |
| MRAgent: an LLM-based automated agent for causal knowledge discovery in disease via Mendelian randomization. | Xu W et al. | β | 2025 | β |
| MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. | van der Graaf A et al. | β | 2025 | β |
| Multidimensional Evidence Chain of Nutritional Impact on Digestive System Tumors: Integration of Mendelian Randomization Causal Inference, NHANES Epidemiological Data, and Transcriptomic Analysis. | Chen Y et al. | β | 2025 | β |
| Multi-omics analysis reveals the impact of thrombotic diseases on the occurrence and prognosis of breast cancer. | Zhong Z et al. | β | 2025 | β |
| Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas. | Li Y et al. | β | 2025 | β |
| Multi-omics identification of circulating protein biomarkers for intervertebral disc degeneration using Mendelian randomization and scRNA-seq. | Bai F et al. | β | 2025 | β |
| Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes. | Hazelwood E et al. | β | 2025 | β |
| Multivariable MR Can Mitigate Bias in Two-Sample MR Using Covariable-Adjusted Summary Associations. | Gilbody J et al. | β | 2025 | β |
| MUTATE: a human genetic atlas of multiorgan artificial intelligence endophenotypes using genome-wide association summary statistics. | Boquet-Pujadas A et al. | β | 2025 | β |
| Na-Cl Cotransporter (SLC12A3) Inhibition Exacerbates Age-Related Macular Degeneration Via the Nrf2/HO-1 Ferroptosis Pathway. | Chen C et al. | β | 2025 | β |
| Navigating the shifting Mendelian randomisation landscape: some observations and suggestions for editors, reviewers and investigators. | Bell S et al. | β | 2025 | β |
| Network pharmacology and experimental validation reveal clotrimazole alleviates dextran sulfate sodium-induced ulcerative colitis by inhibiting intestinal senescence. | Chen C et al. | β | 2025 | β |
| Neurotrophin-3 as a mediator in the link between PM<sub>2.5</sub> exposure and psychiatric disorders: A Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma. | Wang Y et al. | β | 2025 | β |
| No association between anti-cytomegalovirus seropositivity and arthritis: evidence from the cross-sectional epidemiology and genetic association analyses. | Feng C et al. | β | 2025 | β |
| No causal association between gut microbiota and kawasaki disease: a two-sample mendelian randomization study. | Wang S et al. | β | 2025 | β |
| No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis. | Liu P et al. | β | 2025 | β |
| No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods. | Lu T et al. | β | 2025 | β |
| Non-linear Mendelian randomization: evaluation of effect modification in the residual and doubly-ranked methods with simulated and empirical examples. | Hamilton FW et al. | β | 2025 | β |
| Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study. | Yu H et al. | β | 2025 | β |
| Obesity and Cardiometabolic Disease: Insights From Genetic Studies. | Dash S | β | 2025 | β |
| Obstructive sleep apnea and osteoporosis: A bidirectional two-sample mendelian randomization analysis. | Tu Y et al. | β | 2025 | β |
| Omega-6/Omega-3 Ratio as a Protective Factor in Lung Cancer: A Mendelian Randomization Study on Polyunsaturated Fatty Acids and Lung Adenocarcinoma Risk. | Wang C et al. | β | 2025 | β |
| One-carbon metabolism and risk of PCOS: insights from Mendelian randomization. | Zhao Y et al. | β | 2025 | β |
| Outlier Detection in Mendelian Randomization. | Mandl MM et al. | β | 2025 | β |
| Pathophysiological mechanisms of Postural Orthostatic Tachycardia Syndrome analyzed by means of hemodynamics. | Wei L et al. | β | 2025 | β |
| Patterns of perinatal exposure to PUFAs and child neurodevelopment: evidence from Mendelian randomization using FADS cluster variants. | Abou Assi A et al. | β | 2025 | β |
| Perturbations in lipid metabolism mediate the relationship between cholecystectomy and dementia: A mediation Mendelian randomization study. | Gu H et al. | β | 2025 | β |
| Phosphodiesterase-5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study. | Alcalde-Herraiz M et al. | β | 2025 | β |
| Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study. | Chalitsios CV et al. | β | 2025 | β |
| Physical activity associated with age at menopause: A Mendelian randomization study. | Sun X | β | 2025 | β |
| Plasma <i>L</i>-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study. | Wang M et al. | β | 2025 | β |
| Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. | Ao L et al. | β | 2025 | β |
| Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study. | Du G et al. | β | 2025 | β |
| Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis. | Chen L et al. | β | 2025 | β |
| Potential drug targets for intracranial aneurysms identified through Mendelian randomization analysis. | Peng L et al. | β | 2025 | β |
| Pregestational Diabetes and Adverse Pregnancy Results: A Mendelian Randomization Study. | Hantoushzadeh S et al. | β | 2025 | β |
| Premature ovarian insufficiency as a consequence of immunological abnormalities and dyslipidemia: a Mendelian randomization study. | Shao F et al. | β | 2025 | β |
| Prolonged leisure time television watching as a risk factor for chronic obstructive pulmonary disease: Insights from Mendelian randomization. | Li Y et al. | β | 2025 | β |
| Prospective associations between major depressive disorder, generalized anxiety disorder, fibromyalgia, and myalgic encephalomyelitis/chronic fatigue syndrome. | Thomas NS et al. | β | 2025 | β |
| Prospects of Mendelian randomization in hepatology: a comprehensive literature review with practice guidance. | Chen L et al. | β | 2025 | β |
| Protective impact of circulating Ο-3 PUFAs on sepsis susceptibility through <i>PCSK9</i> variant: evidence from Mendelian randomization and animal experiments. | Han Q et al. | β | 2025 | β |
| Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm. | Qi Y et al. | β | 2025 | β |
| Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease. | Gao C et al. | β | 2025 | β |
| Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes. | Daubney ER et al. | β | 2025 | β |
| Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development. | Wu J et al. | β | 2025 | β |
| Reevaluating the obesity paradox across diverse disease outcomes: A Mendelian randomization study. | Cong P et al. | β | 2025 | β |
| Relationship between red cell distribution width and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey. | Liu Y et al. | β | 2025 | β |
| Relationships between Frailty and the Risk of Glaucoma in Middle-aged and Older Adults. | Chen J et al. | β | 2025 | β |
| Research Advance of Causal Inference in Clinical Medicine: A Bibliometrics Analysis via Citespace. | Qin G et al. | β | 2025 | β |
| Revealing the enigmatic interplay between helicobacter pylori infection and biliary system diseases using Mendelian randomization analysis. | Zhou J et al. | β | 2025 | β |
| Risk factors for sacrococcygeal pilonidal sinus: a systematic review and meta-analysis supplemented by genetic causal assessment. | Xu X et al. | β | 2025 | β |
| Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study. | Mac Giollabhui N et al. | β | 2025 | β |
| Role of PD-L1 in mediating the effect of lipid on ulcerative colitis: a mediation Mendelian randomization study. | Li P et al. | β | 2025 | β |
| Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization. | Wang Q et al. | β | 2025 | β |
| Sarcopenia-related traits and risk of falls in older adults: results from meta-analysis of cohort studies and Mendelian randomization analyses. | Yang H et al. | β | 2025 | β |
| Screening and Validation of Potential Biomarkers of Immune Cells in Childhood Asthma Patients via Mendelian Randomization and Machine Learning. | Zhang Y et al. | β | 2025 | β |
| Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis. | Lu S et al. | β | 2025 | β |
| Self-reported myopia and age-related cataract: a two-sample Mendelian randomization study. | Liu H et al. | β | 2025 | β |
| Serum 25-Hydroxyvitamin D Levels and the Risk of Post-Traumatic Wound Infection. | Zhang Z et al. | β | 2025 | β |
| Serum iron levels as a risk factor for Osteoporosis-Related pathological fractures. | Lin S et al. | β | 2025 | β |
| Serum Metabolites as Mediator Between Autoimmune Hyperthyroidism and Epilepsy: A Mendelian Randomization Analysis. | Zhang K et al. | β | 2025 | β |
| Sex differences in risk factor relationships with subarachnoid haemorrhage and intracranial aneurysms: A Mendelian randomization study. | Tschiderer L et al. | β | 2025 | β |
| Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate. | Ng JCM et al. | β | 2025 | β |
| Shared genetic architecture and causal relationship between frailty and schizophrenia. | Deng MG et al. | β | 2025 | β |
| Shared genetic architecture between leukocyte telomere length and Alzheimer's disease. | Cao Z et al. | β | 2025 | β |
| Shared genetic association between inflammatory bowel disease and acute myeloid leukemia: insights from mendelian randomization and transcriptomic analyses. | Zhou Y et al. | β | 2025 | β |
| Shuangdong Capsule Activates Insulin Signal Pathway to Improve Urinary Tract Infection in Diabetic Rats. | Zhao C et al. | β | 2025 | β |
| Single-Cell Dissection of the Serrated Pathway: Cellular Heterogeneity and Genetic Causality in Colorectal Cancer. | Cen M et al. | β | 2025 | β |
| Sleep disturbances and heart failure: observational study and Mendelian randomization study. | Wang J et al. | β | 2025 | β |
| Smoking, Alcohol Consumption, and Atrial Fibrillation: Mendelian Randomization Study. | Ye X et al. | β | 2025 | β |
| Smoking and asthma mediate the protective effect of educational attainment on chronic obstructive pulmonary disease risk: a mediation Mendelian randomization analysis. | Bai X et al. | β | 2025 | β |
| Smoking as a Risk Factor for Cardiovascular Disease in Females and Males: Observational and Mendelian Randomisation Analyses in the UK Biobank. | de Ruiter SC et al. | β | 2025 | β |
| Socioeconomic status, individual behaviors and risk of anxiety disorders: A Mendelian randomization study. | Lu Q et al. | β | 2025 | β |
| Socioeconomic status, individual behaviors and the risk of aneurysmal subarachnoid hemorrhage: a Mendelian randomization study. | Luo S et al. | β | 2025 | β |
| Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study. | Chen Z et al. | β | 2025 | β |
| Species-level enterosignatures predict clinical phenotypes in chronic hepatitis B and causal triangulation of gut-metabolite-CHB interactions. | Yuan T et al. | β | 2025 | β |
| Statins and hemorrhagic stroke: New insight from a Mendelian randomization study. | Gu X et al. | β | 2025 | β |
| Statins as a risk factor for anaemia: Evidence from genetic and epidemiological data. | Liu Z et al. | β | 2025 | β |
| Stratification-based instrumental variable analysis framework for nonlinear effect analysis. | Tian H et al. | β | 2025 | β |
| Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration. | Skrivankova VW et al. | β | 2025 | β |
| Sugar consumption and its role in dental caries: Insights from a 2-sample Mendelian randomization study. | Lim SW et al. | β | 2025 | β |
| SUMMER: A Practical Tool for Identifying Factors and Biomarkers Associated with Pan-cancer Survival. | Xin J et al. | β | 2025 | β |
| Systematic Evaluation of the Impact of a Wide Range of Dietary Habits on Myocardial Infarction: A Two-Sample Mendelian Randomization Analysis. | Yang Q et al. | β | 2025 | β |
| Systolic and diastolic blood pressure, abdominal obesity, and alcohol consumption contribute to the risk of hypertrophic and dilated cardiomyopathies in European and East Asian populations. | Zhang W et al. | β | 2025 | β |
| Tea intake and risk of allergic diseases: A Mendelian randomization study based on a European population. | Ma X et al. | β | 2025 | β |
| Telomere Length as Both Cause and Consequence in Type 1 Diabetes: Evidence from Bidirectional Mendelian Randomization. | Wei G et al. | β | 2025 | β |
| Testing the Causal Association Between Metabolic Syndrome and Periodontitis: A Two-sample Mendelian Randomisation Study. | Yan J et al. | β | 2025 | β |
| The application of mendelian randomization in cancer research: a bibliometric analysis. | Bai Z et al. | β | 2025 | β |
| The association between fatigue and cardiometabolic diseases: Insights from the UK biobank study. | Bian K et al. | β | 2025 | β |
| The Association between Myopia and Anxiety: A Bidirectional 2-Sample Mendelian Randomization Study. | Wong W et al. | β | 2025 | β |
| The brain-joint axis: links between osteoarthritis and neurodegenerative disorders in aging. | Rabie MA et al. | β | 2025 | β |
| The causal associations of 25(OH)D and its metabolites with oropharyngeal cancer risk: a Mendelian randomization study. | Yu Y et al. | β | 2025 | β |
| The causal effect of multiple lifestyles and myopia: a Mendelian randomization study. | Su MR et al. | β | 2025 | β |
| The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis. | Lin S et al. | β | 2025 | β |
| The causal effects of systemic antioxidant capacity on male infertility: A two-sample mendelian randomization analysis. | Zhang X et al. | β | 2025 | β |
| The causal link between socioeconomic status and oral cancer risk: Evidence from Mendelian Randomization and global burden of disease analysis (1990-2021). | Li S et al. | β | 2025 | β |
| The Causal Relationship and Association between Biomarkers, Dietary Intake, and Diabetic Retinopathy: Insights from Mendelian Randomization and Cross-Sectional Study. | Cui X et al. | β | 2025 | β |
| The causal relationship between childhood obesity and adult oral health: A 2-sample Mendelian randomization study. | Zhang H et al. | β | 2025 | β |
| The causal relationship between emotions and osteoarthritis: A bidirectional Mendelian randomization study. | Pan Y et al. | β | 2025 | β |
| The causal relationship between immune cells and knee osteoarthritis: Mendelian randomization study. | Gao C et al. | β | 2025 | β |
| The causal relationship between obstructive sleep apnea and rheumatic disease: A bidirectional Mendelian randomization study. | Chen M et al. | β | 2025 | β |
| The causal relationship between six mental disorders and breast cancer risk: A two-sample Mendelian randomization study. | Hu Q et al. | β | 2025 | β |
| The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota. | Zhang J et al. | β | 2025 | β |
| The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study. | Huang P et al. | β | 2025 | β |
| The differential impact of abdominal obesity on fasting and non-fasting triglycerides and cardiovascular risk. | Christiansen MR et al. | β | 2025 | β |
| The effect of blood glucose and lipid risk factors on idiopathic sudden sensorineural hearing loss: A two-sample Mendelian randomization study. | Deng BY et al. | β | 2025 | β |
| The immune system's mediation of the protective effect of Parabacteroides against obesity: A Mendelian randomization study. | Ouyang Y et al. | β | 2025 | β |
| The impact of cathepsins on liver hepatocellular carcinoma: Insights from genetic and functional analyses. | Liu Q et al. | β | 2025 | β |
| The impact of different types of physical activity on the risk of knee osteoarthritis: A Mendelian randomization study. | Wang G et al. | β | 2025 | β |
| The impact of early-life and prolonged antibiotics exposure on 78 common diseases: Evidence from epidemiology. | Jiang Y et al. | β | 2025 | β |
| The impact of sleep on breast cancer-specific mortality:Β a Mendelian randomisation study. | Hayes BL et al. | β | 2025 | β |
| The impacts of noise and air pollution on breast cancer risk in European and East Asian populations: Insights from genetic evidence. | Yu C et al. | β | 2025 | β |
| The influence of mitochondrial biological function on sudden sensorineural hearing loss: Exploring potential mechanisms and associations through Mendelian randomization analysis. | Chen J et al. | β | 2025 | β |
| The mechanisms of kidney-lung interactions in chronic kidney disease-associated pulmonary diseases: A two-sample Mendelian randomization study. | Yang S et al. | β | 2025 | β |
| The mediating roles of anthropo-metabolic biomarkers on the association between beverage consumption and breast cancer risk. | Lin X et al. | β | 2025 | β |
| Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses. | Li X et al. | β | 2025 | β |
| Therapeutic targets of antidiabetic drugs and kidney stones: A druggable mendelian randomization study and experimental study in rats. | Wu M et al. | β | 2025 | β |
| The rapid growth in Mendelian randomization studies. | Hemani G et al. | β | 2025 | β |
| The relationship between Alzheimer's disease and intracerebral hemorrhage based on Mendelian randomization. | Shen Y et al. | β | 2025 | β |
| The relationship between COVID-19 and stroke and its risk factors, a Mendelian randomization analysis. | Tang C et al. | β | 2025 | β |
| The relationship between gluten-free diet and IgA nephropathy: A review. | Pei T et al. | β | 2025 | β |
| The Relationship Between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures. | Hao Y et al. | β | 2025 | β |
| The relationship between major depression, attention-deficit hyperactivity disorder and coronary artery disease: A two-sample Mendelian randomization analysis. | Zhang X et al. | β | 2025 | β |
| The rise of Mendelian randomization for exploring disease causality: A bibliometric analysis based on CiteSpace. | He K et al. | β | 2025 | β |
| The role of 25-OH vitamin D in Alzheimer's disease through Mendelian randomization and MRI. | Fu LL et al. | β | 2025 | β |
| The Role of 473 Intestinal Microbiota and 91 Inflammatory Factors in Breast Cancer Risk: Insights From Mendel Randomization and its Implications for Diagnosis and Treatment. | Zhu R et al. | β | 2025 | β |
| The role of body image dissatisfaction in the relationship between body size and disordered eating and self-harm: complimentary Mendelian randomization and mediation analyses. | Power GM et al. | β | 2025 | β |
| The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity. | Pistis G et al. | β | 2025 | β |
| The role of estimation in Mendelian randomization: should Mendelian randomization investigations provide estimates? | Woolf B et al. | β | 2025 | β |
| The role of immune cells phenotype in neuroendocrine tumors development. | Qiao J et al. | β | 2025 | β |
| Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development. | Deslandes B et al. | β | 2025 | β |
| Traumatic Brain Injury Increasing Risk of Meningioma? From the Genetic Evidence. | He C et al. | β | 2025 | β |
| Triangulated evidence provides no support for bidirectional causal pathways between diet/physical activity and depression/anxiety. | van Hooijdonk KJM et al. | β | 2025 | β |
| Triangulating Instrumental Variable, confounder adjustment and difference-in-difference methods for comparative effectiveness research in observational data. | GΓΌdemann LM et al. | β | 2025 | β |
| Triangulation evidence for the causal effect of monocytes on pulmonary artery hypertension: a Mendelian randomization study and results from NHANES. | Liu Z et al. | β | 2025 | β |
| Two Birds With One Stone: The Protective Role of the Antidiabetic Drug Sodium-Glucose Cotransporter-2 Inhibitor in Neurodegenerative Diseases. | Zhang L et al. | β | 2025 | β |
| Two-Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation. | Yan J | β | 2025 | β |
| Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and meningioma. | Xin J et al. | β | 2025 | β |
| Two-Sample Network Mendelian Randomization and Single-Cell Analysis Reveal the Causal Associations and Underlying Mechanisms Between Antihypertensive Drugs and Kidney Cancer. | Deng R et al. | β | 2025 | β |
| Type 2 diabetes as a risk factor for promoting hypertrophic scar formation after wound healing: a two-sample mendelian randomization study. | Zheng W et al. | β | 2025 | β |
| Uncovering new MicroRNAs linked to acute pancreatitis: zeroing in on the protective effect. | Zhao C et al. | β | 2025 | β |
| Uncovering novel metabolic and inflammatory pathways in gout using Mendelian randomization. | Li Q et al. | β | 2025 | β |
| Understanding causal estimates of smoking behaviors for cognitive impairment: A Mendelian randomization study. | Fu M et al. | β | 2025 | β |
| Understanding the alcohol harm paradox: A multivariable mendelian randomization approach. | Sawyer G et al. | β | 2025 | β |
| Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation. | Singh M et al. | β | 2025 | β |
| Unraveling the Causal Association Between Circulating Copper Levels and Erectile Dysfunction: A Comprehensive Analysis via Bidirectional Two Sample Mendelian Randomization Study. | Wang Z et al. | β | 2025 | β |
| Unraveling the causal nexus of cathepsins and rheumatoid arthritis: Insights from a two-sample Mendelian randomization framework. | Zhang H et al. | β | 2025 | β |
| Unraveling the Causal Relationship Between Blood Metabolites and Acne: A Metabolomic Mendelian Randomization Study. | Li M et al. | β | 2025 | β |
| Unraveling the interplay between cardiovascular diseases and alcohol use disorder: A bioinformatics and network-based exploration of shared molecular pathways and key biomarkers validation via western blot analysis. | Moon KZ et al. | β | 2025 | β |
| Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study. | Zhu H et al. | β | 2025 | β |
| Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions. | Niu M et al. | β | 2025 | β |
| Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke. | Chakkarai S et al. | β | 2025 | β |
| Unveiling causal links between serum amino acid levels and risk of hepatobiliary neoplasms by Mendelian randomization study. | Zhai A et al. | β | 2025 | β |
| Unveiling novel potential drug targets for lung cancer through Mendelian randomization analysis. | Huang Y et al. | β | 2025 | β |
| Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends? | Yu Y et al. | β | 2025 | β |
| Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study. | Lei H et al. | β | 2025 | β |
| Unveiling the key roles in esophageal cancer drug resistance from a genetic perspective: the interplay between cytokines and immune cell phenotypes. | Yan H et al. | β | 2025 | β |
| Using Mendelian randomization to investigate etiologic heterogeneity across renal cell carcinoma subtypes. | Winter TD et al. | β | 2025 | β |
| Vitamin A, Vitamin D, Iron, and Zinc in Relation to Anemia Risk: Observational Evidence and Mendelian Randomization. | Tang J et al. | β | 2025 | β |
| Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders. | Xu H et al. | β | 2025 | β |
| Woolf et al's "GWAS by subtraction" is not useful for cross-generational Mendelian randomization studies. | Evans DM et al. | β | 2025 | β |
| ZDHHC13 Reduces the Risk of Ischemic Stroke by Regulating Metabolites. | Wei Z et al. | β | 2025 | β |
| Absence of genetic association between insulin-like growth factors and esophageal cancer. | Sun Z et al. | β | 2024 | β |
| A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study. | Wang M et al. | β | 2024 | β |
| A comprehensive assessment of the association between common drugs and psychiatric disorders using Mendelian randomization and real-world pharmacovigilance database. | Chen Z et al. | β | 2024 | β |
| A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data. | Mustafa R et al. | β | 2024 | β |
| ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-Ξ²1 activation in lung adenocarcinoma. | Xiao L et al. | β | 2024 | β |
| Addressing the credibility crisis in Mendelian randomization. | Burgess S et al. | β | 2024 | β |
| A genetically informed study reveals modifiable pathways in skin cancer. | Qian H et al. | β | 2024 | β |
| A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study. | Liu B et al. | β | 2024 | β |
| Alcohol consumption and allergic diseases: Mendelian randomization evidence from China. | Zhu C et al. | β | 2024 | β |
| 'Almost nothing is firmly established': A History of Heredity and Genetics in Mental Health Science. | Chaney S et al. | β | 2024 | β |
| A Modified Debiased Inverse-Variance Weighted Estimator in Two-Sample Summary-Data Mendelian Randomization. | Su Y et al. | β | 2024 | β |
| A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer. | Wu D et al. | β | 2024 | β |
| Analysis of the causal relationship between immune cells and rheumatoid arthritis from the perspective of genetic variation: a bidirectional two-sample Mendelian randomization study. | Cheng F et al. | β | 2024 | β |
| Ankylosing spondylitis and cardiovascular disease: A two-sample Mendelian randomization analysis. | Chen H et al. | β | 2024 | β |
| Application of Mendelian randomized research method in oncology research: bibliometric analysis. | Chen J et al. | β | 2024 | β |
| Aspirin may be more suitable for patients with major depression: Evidence from two-sample Mendelian randomization analysis. | Zhu H et al. | β | 2024 | β |
| Association between circulating micronutrients and their supplements and risk of deep vein thrombosis: A Mendelian randomization study. | Huang Y et al. | β | 2024 | β |
| Association between circulating micronutrients and their supplements and the risk of rotator cuff injury: A multivariate mendelian randomization study. | Huang YT et al. | β | 2024 | β |
| Association between dietary tea consumption and non-alcoholic fatty liver disease: a study based on Mendelian randomisation and National Health and Nutrition Examination Survey (2005-2018) association between tea and non-alcoholic fatty liver disease. | Liu S et al. | β | 2024 | β |
| Association between gastroesophageal reflux disease and metabolic syndrome: a bidirectional two-sample Mendelian randomization analysis. | He T et al. | β | 2024 | β |
| Association between idiopathic normal pressure hydrocephalus and Alzheimer's disease: a bidirectional Mendelian randomization study. | Hu Y et al. | β | 2024 | β |
| Association between levels of sex hormones and risk of multiple sclerosis: a mendelian randomization study. | Geng C et al. | β | 2024 | β |
| Association between proton pump inhibitors and dementia risk: a Mendelian randomization study. | Xie K et al. | β | 2024 | β |
| Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007-2020 and Mendelian randomization analysis. | He J et al. | β | 2024 | β |
| Association between systemic lupus erythematosus and common female reproductive system malignancies. | Sirong C et al. | β | 2024 | β |
| Association of cardiovascular disease and urate levels with aortic aneurysm: a bilateral mendelian randomization study. | Xiao Y et al. | β | 2024 | β |
| Association of dietary intake with pneumothorax: A Mendelian randomization study. | Liang Q et al. | β | 2024 | β |
| Association of Lactate with Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study. | Chang X et al. | β | 2024 | β |
| Association of serum uric acid with male sexual hormones and erectile dysfunction: a bidirectional 2-sample Mendelian randomization analysis. | Chen H et al. | β | 2024 | β |
| Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Associations of cholecystectomy with the risk of gastroesophageal reflux disease: a Mendelian randomization study. | Qian J et al. | β | 2024 | β |
| Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study. | Tong B et al. | β | 2024 | β |
| Associations of intestinal diseases with anal diseases: a Mendelian randomization study. | Zeng X et al. | β | 2024 | β |
| A two sample mendelian randomization analysis investigates causal effects between gut microbiome and immune related Vasculitis. | Chen S et al. | β | 2024 | β |
| A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism. | Strausz T et al. | β | 2024 | β |
| Basophils may as a risk factor for upper gastrointestinal cancer: a Mendelian randomization (MR) study. | Nov P et al. | β | 2024 | β |
| Behavioral risk factors and socioeconomic inequalities in ischemic heart disease mortality in the United States: A causal mediation analysis using record linkage data. | Zhu Y et al. | β | 2024 | β |
| Bi-directional effects between inflammatory molecules and intracranial aneurysm. | Liu J et al. | β | 2024 | β |
| Bidirectional influence between benign prostatic hyperplasia, prostate cancer, and prostatitis and mental disorders: two-sample and multivariate mendelian randomization analyses. | Chen X et al. | β | 2024 | β |
| Bidirectional Mendelian Randomization to Elucidate the Relationship Between Healthy Sleep, Brains, and Hearts. | Wolford BN et al. | β | 2024 | β |
| Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways. | Guo J et al. | β | 2024 | β |
| Cancers and erectile dysfunction: a Mendelian randomization study. | Yang G et al. | β | 2024 | β |
| Can early gut microbiota screening reduce the incidence of cognitive impairment? A Mendelian randomization study. | Xi C et al. | β | 2024 | β |
| Can Omega-3 prevent the accidence of stroke: a mendelian randomization study. | Xi C et al. | β | 2024 | β |
| Cardiometabolic traits mediating the effect of education on the risk of DKD and CKD: a Mendelian randomization study. | Wang Y et al. | β | 2024 | β |
| Cathepsins and neurological diseases: a Mendelian randomization study. | Sun H et al. | β | 2024 | β |
| Causal association between epigenetic age acceleration and two pulmonary vascular diseases: pulmonary arterial hypertension and pulmonary embolism-a bidirectional Mendelian study. | Tong J et al. | β | 2024 | β |
| Causal association between peripheral immune cells and IgA nephropathy: a Mendelian randomization study. | Liang LM et al. | β | 2024 | β |
| Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies. | Yang L et al. | β | 2024 | β |
| Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study. | Shen B et al. | β | 2024 | β |
| Causal association of menstrual reproductive factors on the risk of osteoarthritis: A univariate and multivariate Mendelian randomization study. | Tan X et al. | β | 2024 | β |
| Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study. | Huang Y et al. | β | 2024 | β |
| Causal association of sex hormone-binding globulin on gestational hypertension and pre-eclampsia: a two-sample Mendelian randomization study. | Wu Z et al. | β | 2024 | β |
| Causal associations between fluid intake patterns and dermatitis risk: a Mendelian randomization study. | Zeng R et al. | β | 2024 | β |
| Causal associations between gut microbiota and premature rupture of membranes: a two-sample Mendelian randomization study. | Zhang L et al. | β | 2024 | β |
| Causal associations between <i>Helicobacter Pylori</i> infection and the risk and symptoms of Parkinson's disease: a Mendelian randomization study. | Wang X et al. | β | 2024 | β |
| Causal associations between severe COVID-19 and diseases of seven organs: a proteome-wide mendelian randomization study. | Shen Y et al. | β | 2024 | β |
| Causal associations between the insulin-like growth factor family and sarcopenia: a bidirectional Mendelian randomization study. | Liu J et al. | β | 2024 | β |
| Causal associations between type 2 diabetes mellitus, glycemic traits, dietary habits and the risk of pressure ulcers: univariable, bidirectional and multivariable Mendelian randomization. | Luo P et al. | β | 2024 | β |
| Causal associations of ambient particulate matter 10 and Alzheimer's disease: result from a two-sample multivariable Mendelian randomization study. | Huang Z et al. | β | 2024 | β |
| Causal associations of hypothyroidism with frozen shoulder: a two-sample bidirectional Mendelian randomization study. | Chen B et al. | β | 2024 | β |
| Causal associations of white blood cell count and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study. | Zhang L et al. | β | 2024 | β |
| Causal effect between breast cancer and ovarian cancer: a two-sample mendelian randomization study. | Qian C et al. | β | 2024 | β |
| Causal effect of fasting serum glucose on atherosclerotic cardiovascular disease: a multivariable Mendelian randomization. | Lee SH et al. | β | 2024 | β |
| Causal effect of obesity and adiposity distribution on the risk of pressure ulcers and potential mediation by type 2 diabetes mellitus: insights from multivariable mendelian randomization and mediation analysis. | Huang C et al. | β | 2024 | β |
| Causal effects of genetically determined blood metabolites on asthma: a bidirectional Mendelian randomization study. | Lin L et al. | β | 2024 | β |
| Causal effects of obstructive sleep apnea on chronic kidney disease and renal function: a bidirectional Mendelian randomization study. | Hou Y et al. | β | 2024 | β |
| Causal effects of sepsis on structural changes in cerebral cortex: A Mendelian randomization investigation. | Zhou D et al. | β | 2024 | β |
| Causal effects of specific gut microbiota on spinal stenosis diseases: a two-sample mendelian randomization study. | Luo K et al. | β | 2024 | β |
| Causal factors for osteoarthritis risk revealed by mendelian randomization analysis. | Luo Q et al. | β | 2024 | β |
| Causal influence of immune factors on the risk of diabetic retinopathy: a mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Causal influence of plasma metabolites on age-related macular degeneration: A Mendelian randomization study. | Wang T et al. | β | 2024 | β |
| Causal interpretations of family GWAS in the presence of heterogeneous effects. | Veller C et al. | β | 2024 | β |
| Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population. | Zhang H et al. | β | 2024 | β |
| Causality between herpes virus infections and allograft dysfunction after tissue and organ transplantation: a two-sample bidirectional Mendelian randomization study. | Qiu X et al. | β | 2024 | β |
| Causality investigation among gut microbiota, immune cells, and prostate diseases: a Mendelian randomization study. | Yue SY et al. | β | 2024 | β |
| Causal relationship analysis between 35 blood/urine metabolites and gastroesophageal reflux disease: A Mendelian randomization combined meta-analysis study. | Chen D et al. | β | 2024 | β |
| Causal relationship between air pollution and infections: a two-sample Mendelian randomization study. | Yang S et al. | β | 2024 | β |
| Causal relationship between beta-2 microglobulin and B-cell malignancies: genome-wide meta-analysis and a bidirectional two-sample Mendelian randomization study. | Li J et al. | β | 2024 | β |
| Causal relationship between cathepsins and major salivary gland neoplasms: a bidirectional Mendelian randomization study. | Zhuang S et al. | β | 2024 | β |
| Causal relationship between cheese intake and risk of gastroesophageal reflux disease and Barrett's esophagus: findings from multivariable mendelian randomization and mediation analysis. | Zhou J et al. | β | 2024 | β |
| Causal relationship between circulating levels of cytokines and bone mineral density: A mendelian randomization study. | Xu T et al. | β | 2024 | β |
| Causal relationship between fertility nutrients supplementation and PCOS risk: a Mendelian randomization study. | Shao F et al. | β | 2024 | β |
| Causal relationship between genetically determined plasma metabolites and stroke: A two sample Mendelian randomization study. | Huang Y et al. | β | 2024 | β |
| Causal relationship between genetic-predicted uric acid and cervical cancer risk: evidence for nutritional intervention on cervical cancer prevention. | Cao C et al. | β | 2024 | β |
| Causal relationship between gut microbiota and insulin-like growth factor 1: a bidirectional two-sample Mendelian randomization study. | Zheng X et al. | β | 2024 | β |
| Causal relationship between immune cells and pulmonary arterial hypertension: Mendelian randomization analysis. | Du D et al. | β | 2024 | β |
| Causal relationship between immune cells and risk of myocardial infarction: evidence from a Mendelian randomization study. | Cao W et al. | β | 2024 | β |
| Causal relationship between insomnia and thyroid disease: A bidirectional Mendelian randomization study. | Li Z et al. | β | 2024 | β |
| Causal relationship between sleep characteristics and thyroid function: A bidirectional Mendelian randomization study. | Jia Z et al. | β | 2024 | β |
| Causal relationship between systemic circulatory inflammatory regulators and intervertebral disc degeneration: A bidirectional 2-sample Mendelian randomization study. | Chen ZX et al. | β | 2024 | β |
| Causal relationships between allergic and autoimmune diseases with chronic rhinosinusitis. | Tu J et al. | β | 2024 | β |
| Causal relationships between depression, emotional changes, and hiatal hernia: A Mendelian randomization analysis. | Pan C et al. | β | 2024 | β |
| Causal relationships between dietary antioxidant vitamin intake and atopic dermatitis: A two-sample Mendelian randomization study. | Wang S et al. | β | 2024 | β |
| Causal Relationships Between Emotional Instability and Respiratory Diseases: A Mendelian Randomization Analysis. | Ma X et al. | β | 2024 | β |
| Causal Relationships Between Leukocyte Subsets and Adverse Fetal Outcomes: A Mendelian Randomization Study. | Chen H et al. | β | 2024 | β |
| Causal relationships between obesity-related anthropometric indicators and sepsis risk: a Mendelian-randomization study. | Zhang C et al. | β | 2024 | β |
| Causal role of immune cells in diabetic nephropathy: a bidirectional Mendelian randomization study. | Wang SY et al. | β | 2024 | β |
| Causation between the gut microbiota and inguinal hernia: a two-sample double-sided Mendelian randomization study. | Wu C et al. | β | 2024 | β |
| Circadian gene signatures in the progression of obesity based on machine learning and Mendelian randomization analysis. | Cheng Z et al. | β | 2024 | β |
| Circulating levels of micronutrients and risk of osteomyelitis: a Mendelian randomization study. | Zhang X et al. | β | 2024 | β |
| Common pitfalls in drug target Mendelian randomization and how to avoid them. | Gill D et al. | β | 2024 | β |
| Correlation between benign prostatic hyperplasia and comorbidities: a systematic analysis integrating global burden of disease and mendelian randomization study. | Song Z et al. | β | 2024 | β |
| COVID-19, vaccination and migraine: Causal association or epiphenomenon? | Jiang H et al. | β | 2024 | β |
| Deciphering proteins in Alzheimer's disease: A new Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction. | Yao M et al. | β | 2024 | β |
| Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization. | Liu Y et al. | β | 2024 | β |
| Deciphering the genetics and mechanisms of predisposition to multiple myeloma. | Went M et al. | β | 2024 | β |
| Deciphering the mediating role of CXCL10 in hypothyroidism-induced idiopathic pulmonary fibrosis in European ancestry: a Mendelian randomization study. | Xing X et al. | β | 2024 | β |
| Decoding skin mysteries: Unveiling the link between microbiota and keloid scars through a Mendelian randomization study. | Zhou J et al. | β | 2024 | β |
| Depression and the risk of fibromyalgia syndrome: a two-sample Mendelian randomization study. | Ma X et al. | β | 2024 | β |
| Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry. | Zhou X et al. | β | 2024 | β |
| Diet-derived circulating antioxidants and functional outcome after ischemic stroke: Evidence from genetic studies. | Li X et al. | β | 2024 | β |
| Dissecting Causal Relationships Between Dietary Habits and Diverse Subtypes of Stroke: Mendelian Randomization Study. | Cao Y et al. | β | 2024 | β |
| DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study. | Schuurmans IK et al. | β | 2024 | β |
| Do Children Cause the Cognitive Stimulation they Receive? Modelling the Direction of Causality. | Starr A et al. | β | 2024 | β |
| Elucidating the Causal Impact of Dietary Factors on Rheumatoid Arthritis: Insights From Multivariable Mendelian Randomization Analysis. | Lu Y et al. | β | 2024 | β |
| Employing Multi-Omics Analyses to Understand Changes during Kidney Development in Perinatal Interleukin-6 Animal Model. | Panzade G et al. | β | 2024 | β |
| Epigenetic Aging and Risk of Obstructive Sleep Apnea: a bidirectional Mendelian randomization study | Xu C et al. | β | 2024 | β |
| Erroneous epidemiological findings on vitamins: coming full circle after two decades of Mendelian randomization? | Davey Smith G et al. | β | 2024 | β |
| Estimating and visualising multivariable Mendelian randomization analyses within a radial framework. | Spiller W et al. | β | 2024 | β |
| Estimating Time-Varying Exposure Effects Through Continuous-Time Modelling in Mendelian Randomization. | Tian H et al. | β | 2024 | β |
| Evaluating the association between immunological proteins and common intestinal diseases using a bidirectional two-sample Mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| Evaluating the relationship between standing height, body mass index, body fat percentage with risk of inguinal hernia: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Evidence of the association between asthma and lung cancer risk from mendelian randomization analysis. | Ye L et al. | β | 2024 | β |
| Examining the causal association between moderate alcohol consumption and cardiovascular risk factors in the Taiwan Biobank: a Mendelian randomization analysis. | Chien PS et al. | β | 2024 | β |
| Explore genetic susceptibility association between viral infections and Guillain-BarrΓ© syndrome risk using two-sample Mendelian randomization. | Kong QX et al. | β | 2024 | β |
| Exploring causal effects of sarcopenia on risk and progression of Parkinson disease by Mendelian randomization. | Wang T et al. | β | 2024 | β |
| Exploring genetic associations between metabolites and atopic dermatitis: insights from bidirectional Mendelian randomization analysis in European population. | He A et al. | β | 2024 | β |
| Exploring Pathogenic Genes in Frozen Shoulder through weighted gene co-expression network analysis and Mendelian Randomization. | Wen D et al. | β | 2024 | β |
| Exploring Sex Differences in Pain Manifestation of Coronary Artery Disease through Mendelian Randomization. | Methorst R et al. | β | 2024 | β |
| Exploring the bidirectional causal associations between pain and circulating inflammatory proteins: A Mendelian randomization study. | Wang Y et al. | β | 2024 | β |
| Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study. | Cai G et al. | β | 2024 | β |
| Exploring the Causal Relationship between Ibuprofen Use and Osteoarthritis Risk: A Mendelian Randomization Study. | Jian Y et al. | β | 2024 | β |
| Exploring the causal relationship between the immune cell-inflammatory factor axis and lung cancer: a Mendelian randomization study. | Zhu L et al. | β | 2024 | β |
| Exploring the impact of metabolites function on heart failure and coronary heart disease: insights from a Mendelian randomization (MR) study. | Virak V et al. | β | 2024 | β |
| Exploring the potential link between gut microbiota and chronic kidney disease in causality: A 2-sample Mendelian randomization study. | Zhang WW et al. | β | 2024 | β |
| Genetically Determined Plasma Docosahexaenoic Acid Showed a Causal Association with Female Reproductive Longevity-Related Phenotype: A Mendelian Randomization Study. | Gao H et al. | β | 2024 | β |
| Genetically predicted circulating concentrations of micronutrients and risk of autoimmune thyroiditis: a Mendelian randomized study. | Qiu R et al. | β | 2024 | β |
| Genetically predicted circulating linoleic acid levels and risk of osteoarthritis: a two-sample mendelian randomization study. | Yang W et al. | β | 2024 | β |
| Genetically predicted hypothyroidism, thyroid hormone treatment, and the risk of cardiovascular diseases: a mendelian randomization study. | Zhang S et al. | β | 2024 | β |
| Genetic association between mitochondrial DNA copy number and glioma risk: insights from causality. | He Q et al. | β | 2024 | β |
| Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer. | Zhao J et al. | β | 2024 | β |
| Genetic causality of lipidomic and immune cell profiles in ischemic stroke. | Chen H et al. | β | 2024 | β |
| Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk. | Yan M et al. | β | 2024 | β |
| Genetic effect of basal metabolic rate on the benign neoplasm of bone and articular cartilage: a Mendelian randomization study. | Huang G et al. | β | 2024 | β |
| Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways. | Wang Y et al. | β | 2024 | β |
| Genetic evidence causally linking gastroesophageal reflux disease to cholecystitis: a two-sample mendelian randomization study. | Wang C et al. | β | 2024 | β |
| Genetic evidence of bidirectional mendelian randomization study on the causality between gut microbiome and respiratory diseases contributes to gut-lung axis. | Zhou X et al. | β | 2024 | β |
| Genetic evidence supporting the causal role of 25-hydroxyvitamin D levels in the prognosis of ER- breast cancer: A Mendelian randomization study. | Wu S et al. | β | 2024 | β |
| Genetic insights into the gut microbiota and risk of psoriasis: a bidirectional mendelian randomization study. | Qian M et al. | β | 2024 | β |
| Genetic links between ovarian ageing, cancer risk and de novo mutation rates. | Stankovic S et al. | β | 2024 | β |
| Genetic prediction of blood metabolites mediating the relationship between gut microbiota and Alzheimer's disease: a Mendelian randomization study. | Chen G et al. | β | 2024 | β |
| Genetic prediction of serum micronutrient levels and the risk of frailty: Evidence from a Mendelian randomization study. | Wen B et al. | β | 2024 | β |
| Genetic proxies for therapy of insulin drug targets and risk of osteoarthritis: a drug-target Mendelian randomization analysis. | Cao Z et al. | β | 2024 | β |
| Genetics-driven risk predictions leveraging the Mendelian randomization framework. | Sens D et al. | β | 2024 | β |
| Genetic susceptibility association between viral infection and colorectal cancer risk: a two-sample Mendelian randomization analysis. | Li G et al. | β | 2024 | β |
| Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants. | Qi G et al. | β | 2024 | β |
| Glucagon-like peptide-1 receptor agonists and the risk of erectile dysfunction: a drug target Mendelian randomization study. | An H et al. | β | 2024 | β |
| Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization. | Zhou K et al. | β | 2024 | β |
| High lipoprotein(a) is a risk factor for peripheral artery disease, abdominal aortic aneurysms, and major adverse limb events. | Thomas PE et al. | β | 2024 | β |
| HIV and risk of hypertension: a two-sample Mendelian randomization study. | Zhu RW et al. | β | 2024 | β |
| Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens. | Zhang W et al. | β | 2024 | β |
| How can ethology inform the neuroscience of fear, aggression and dominance? | Battivelli D et al. | β | 2024 | β |
| How do immune cells shape type 1 diabetes? Insights from Mendelian randomization. | Yu Y et al. | β | 2024 | β |
| Hypoglycemic drugs, circulating inflammatory proteins, and gallbladder diseases: A mediation mendelian randomization study. | Wang ZQ et al. | β | 2024 | β |
| Identification of Brain Cell Type-Specific Therapeutic Targets for Glioma From Genetics. | Gui J et al. | β | 2024 | β |
| Identification of potential therapeutic targets for skin cutaneous melanoma on the basic of transcriptomics. | Shi F et al. | β | 2024 | β |
| Identifying potential causal effects of Parkinson's disease: A polygenic risk score-based phenome-wide association and mendelian randomization study in UK Biobank. | Shi C et al. | β | 2024 | β |
| Identifying potential repurposable medications for Parkinson's disease through Mendelian randomization analysis. | Wang Q et al. | β | 2024 | β |
| IL-20RA is Associated with the Risk of Diabetic Microangiopathy: A Bidirectional Mendelian Randomization Analysis and Clinical Validation. | Li J et al. | β | 2024 | β |
| Immune thrombocytopenia increases the risk of thrombosis: A two-sample Mendelian randomization study. | Yu J et al. | β | 2024 | β |
| Impact of Alcohol Consumption on Lifespan: a Mendelian randomization study in Europeans. | Jiesisibieke ZL et al. | β | 2024 | β |
| Inflammatory factors and risk of lung adenocarcinoma: a Mendelian randomization study mediated by blood metabolites. | Ding Z et al. | β | 2024 | β |
| INTEGRATING MENDELIAN RANDOMIZATION WITH CAUSAL MEDIATION ANALYSES FOR CHARACTERIZING DIRECT AND INDIRECT EXPOSURE-TO-OUTCOME EFFECTS. | Yang F et al. | β | 2024 | β |
| Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale. | Hoang N et al. | β | 2024 | β |
| Integrative analysis revealed novel putative therapeutic targets of ulcerative colitis: Role of creatine. | Zhu J et al. | β | 2024 | β |
| Interplay between immune cells and metabolites in epilepsy: insights from a Mendelian randomization analysis. | Wang K et al. | β | 2024 | β |
| Investigating the causal association between heme oxygenase-1 and asthma: A bidirectional two-sample Mendelian randomization analysis in a European population. | Liu W et al. | β | 2024 | β |
| Investigating the causal impact of different types of physical activity on psychiatric disorders across life stages: A Mendelian randomization study. | Yu L et al. | β | 2024 | β |
| Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study. | Zheng G et al. | β | 2024 | β |
| Investigating the Gene Relation Between Cervical Spondylosis and Depression: Bidirectional Mendelian Randomization Study. | Lv X et al. | β | 2024 | β |
| Investigating the Impact of Circulating MicroRNAs on Knee and Hip Osteoarthritis: Causal Links, Biological Mechanisms, and Drug Interactions. | Li S et al. | β | 2024 | β |
| Investigation of causal associations between cerebral cortical structure and Barrett's esophagus: insights from Mendelian randomization and meta-analysis. | Liu Q et al. | β | 2024 | β |
| Lactobacillaceae-mediated eye-brain-gut axis regulates high myopia-related anxiety: from the perspective of predictive, preventive, and personalized medicine. | Mi Y et al. | β | 2024 | β |
| Leisure screen time and diabetic retinopathy risk: A Mendelian randomization study. | Tang YY et al. | β | 2024 | β |
| Leukocyte telomere length and lung function: a mendelian randomization study in European population. | Zhu S et al. | β | 2024 | β |
| Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies. | Lessard S et al. | β | 2024 | β |
| Major Psychiatric Disorders, Substance Use Behaviors, and Longevity. | Rosoff DB et al. | β | 2024 | β |
| Managing the exponential growth of mendelian randomization studies. | Munafo MR et al. | β | 2024 | β |
| Managing the exponential growth of Mendelian randomization studies. | MunafΓ² MR et al. | β | 2024 | β |
| Managing the Exponential Growth of Mendelian Randomization Studies. | MunafΓ² M et al. | β | 2024 | β |
| Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study. | Zhang J et al. | β | 2024 | β |
| Mendelian insights: Irritable bowel syndrome as a predictor of upper urinary tract calculi. | Gao S et al. | β | 2024 | β |
| Mendelian randomization analyses explore the effects of micronutrients on different kidney diseases. | Shi C et al. | β | 2024 | β |
| Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer. | Pei B et al. | β | 2024 | β |
| Mendelian randomization analyses support causal relationships between systemic lupus erythematosus and brain imaging-derived phenotypes. | Ma Y et al. | β | 2024 | β |
| Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa). | D'Urso S et al. | β | 2024 | β |
| Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms. | Cao C et al. | β | 2024 | β |
| Mendelian randomization analysis using multiple biomarkers of an underlying common exposure. | Jin J et al. | β | 2024 | β |
| Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes. | Chen J et al. | β | 2024 | β |
| Mendelian randomization study of the relationship between blood and urine biomarkers and lung cancer. | Huang H et al. | β | 2024 | β |
| Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites. | Hu D et al. | β | 2024 | β |
| Mendelian randomization study reveals causal effects of specific gut microbiota on the risk of interstitial cystitis/bladder pain syndrome (IC/BPS). | Jiang P et al. | β | 2024 | β |
| Mitochondrial related Mendelian randomization identifies causal associations between metabolic disorders and childhood neurodevelopmental disorders. | Hu C et al. | β | 2024 | β |
| MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures. | Zhang W et al. | β | 2024 | β |
| MR-SPLIT: A novel method to address selection and weak instrument bias in one-sample Mendelian randomization studies. | Shi R et al. | β | 2024 | β |
| Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices. | BaHammam AS et al. | β | 2024 | β |
| New insights into the increased risk of migraines from COVID-19 infection and vaccination: a Mendelian randomization study. | Yang J et al. | β | 2024 | β |
| No causal relationship between serum vitamin D levels and alcoholic liver disease: a two-sample bidirectional Mendelian randomization study. | Wu H et al. | β | 2024 | β |
| Non-linear Mendelian randomization publications on vitamin D report spurious findings and require major correction. | Davey Smith G | β | 2024 | β |
| Peripheral immunological characteristics of spontaneous pneumothorax: a Mendelian randomization study. | Ruan L et al. | β | 2024 | β |
| Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases. | OrtΓn Vela S et al. | β | 2024 | β |
| Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus. | Cao J et al. | β | 2024 | β |
| Plasma proteins, circulating metabolites mediate causal inference studies on the effect of gut bacteria on the risk of osteoporosis development. | Zhang B et al. | β | 2024 | β |
| Postpartum depression and autoimmune disease: a bidirectional Mendelian randomization study. | Yu W et al. | β | 2024 | β |
| Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables. | Khan M et al. | β | 2024 | β |
| Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: a Mendelian randomization study. | Wang H et al. | β | 2024 | β |
| Prolonged moderate to vigorous physical activity may lead to a decline in cognitive performance: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Proteome-Wide Mendelian Randomization Analysis to Identify Potential Plasma Biomarkers and Therapeutic Targets for Epithelial Ovarian Cancer Subtypes. | Lin Q et al. | β | 2024 | β |
| Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease. | Zhao P et al. | β | 2024 | β |
| Proteome-wide mendelian randomization identifies therapeutic targets for nephrolithiasis. | Wang L et al. | β | 2024 | β |
| Racial Disparities in Plastic Surgery Outcomes: A Systematic Literature Review and Meta-Analysis. | Skorochod R et al. | β | 2024 | β |
| Reclaiming mendelian randomization from the deluge of papers and misleading findings. | Stender S et al. | β | 2024 | β |
| Relationship between circulating white blood cell count and inflammatory skin disease: a bidirectional mendelian randomization study. | Yuan J et al. | β | 2024 | β |
| Relationship between hypothyroidism and chronic kidney disease: Results from the National Health and Nutrition Examination Survey 2007 to 2012 and Mendelian randomization study. | Xu Y et al. | β | 2024 | β |
| Relationship between socioeconomic status and stroke: An observational and network Mendelian randomization study. | Zhang R et al. | β | 2024 | β |
| Role of Genetic Testing in Kidney Stone Disease: A Narrative Review. | Geraghty R et al. | β | 2024 | β |
| Sedentary and 21 gastrointestinal disorders: A Mendelian randomization study. | Lin Y et al. | β | 2024 | β |
| Sedentary behavior from television watching elevates GlycA levels: A bidirectional Mendelian randomization study. | Miao S et al. | β | 2024 | β |
| Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue. | Li Y et al. | β | 2024 | β |
| SNP analysis of stress-related genes reveals significant correlations with drug addiction in Jordan. | Al-Eitan L et al. | β | 2024 | β |
| Systemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study. | Liu X et al. | β | 2024 | β |
| Systemic inflammatory regulators are associated with two common types of neuropathic pain: A bidirectional Mendelian randomization study. | Wang H et al. | β | 2024 | β |
| The association between fruit and vegetable intake and gastrointestinal cancers risk from Mendelian randomization analysis. | Wei J et al. | β | 2024 | β |
| The association between overweight and varying degrees of obesity with subjective well-being and depressive symptoms: A two sample Mendelian randomization study. | Luo X et al. | β | 2024 | β |
| The association between type 1 diabetes mellitus and the risk of immunoglobulin A nephropathy: a Mendelian randomization study. | Zhang CH et al. | β | 2024 | β |
| The causal association between gut microbiota and postpartum depression: a two-sample Mendelian randomization study. | Jin W et al. | β | 2024 | β |
| The causal association of smoking, alcohol intake, and coffee intake with the risk of bacterial pneumonia: A Mendelian randomization study. | He Z et al. | β | 2024 | β |
| The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study. | Sun W et al. | β | 2024 | β |
| The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study. | Shen G et al. | β | 2024 | β |
| The causality between gut microbiota and functional dyspepsia: A two-sample Mendelian randomization analysis. | Jin X et al. | β | 2024 | β |
| The causality of atrial fibrillation on frailty index: A Mendelian randomization study. | Chen S et al. | β | 2024 | β |
| The causal relationship between gut microbiota and 2 neoplasms, malignant and benign neoplasms of bone and articular cartilage: A two-sample Mendelian randomization study. | Lv J et al. | β | 2024 | β |
| The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study. | He N et al. | β | 2024 | β |
| The causal relationship between immune cells and hepatocellular carcinoma: a Mendelian randomization (MR). | Nov P et al. | β | 2024 | β |
| The causal relationship between trace element status and upper gastrointestinal ulcers: a Mendelian randomization study. | Liu J et al. | β | 2024 | β |
| The causal relationship between triglycerides and myocardial infarction: A two-sample Mendelian randomization. | Kong L et al. | β | 2024 | β |
| The causal relationship between type 2 diabetes mellitus and isolated REM sleep behavior disorder: results from multivariable and network Mendelian randomization analysis. | Zhang RY et al. | β | 2024 | β |
| The causal relationship of DTI phenotypes and epilepsy: A two sample mendelian randomization study. | Feng S et al. | β | 2024 | β |
| The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data. | Zheng J et al. | β | 2024 | β |
| The effects of coagulation factors on the risk of autoimmune diseases: A Mendelian randomization study. | Li S et al. | β | 2024 | β |
| The genetic causal association between arthritis and low back pain. | Gong A et al. | β | 2024 | β |
| The impact of metabolic syndrome on the cerebral cortex: a Mendelian randomization study. | Zhang P et al. | β | 2024 | β |
| The impact of sex hormones on metabolic syndrome: univariable and multivariable Mendelian randomization studies. | Liu S et al. | β | 2024 | β |
| The involvement of effector memory CD4<sup>+</sup> T cells in mediating the impact of genus <i>Oscillibacter</i> gut microbiota on Alzheimer's disease: a Mendelian randomization study. | Zhang H et al. | β | 2024 | β |
| The mediating role of metabolites between gut microbiome and Hirschsprung disease: a bidirectional two-step Mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| The mediating role of primary sclerosing cholangitis in the association between ulcerative colitis and hepatobiliary cancer investigated through Mendelian randomization. | Wang F et al. | β | 2024 | β |
| The potential protective effect of 3-Hydroxybutyrate against aortic dissection: a mendelian randomization analysis. | Qiu S et al. | β | 2024 | β |
| The relationship between metabolite mediated immune regulatory imbalance and the occurrence of malignant tumors of bone and articular cartilage: a Mendelian randomization study. | Long K et al. | β | 2024 | β |
| The role of cerebrospinal fluid metabolites in mediating the impact of lipids on Late-Onset Alzheimer's Disease: a two-step mendelian randomization analysis. | Jie J et al. | β | 2024 | β |
| The role of micronutrients and serum metabolites in intervertebral disk degeneration: insights from a Mendelian randomization study and mediation analysis. | Jiang N et al. | β | 2024 | β |
| Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium. | Zeng W et al. | β | 2024 | β |
| Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy. | Hao L et al. | β | 2024 | β |
| Two-sample Mendelian randomization analysis of the relationship between periodontitis and risk of upper gastrointestinal cancers. | Mi S et al. | β | 2024 | β |
| Type 1 diabetes mellitus increases the risk of sudden sensorineural hearing loss: A two-sample Mendelian randomization study. | Ding Y et al. | β | 2024 | β |
| Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy. | Brito Nunes C et al. | β | 2024 | β |
| Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence. | Liu Z et al. | β | 2024 | β |
| Unraveling the hidden link: neuroticism as a risk factor for upper urinary tract calculi-insights from Mendelian randomization analysis. | Gao S et al. | β | 2024 | β |
| Unraveling the link between sterol ester and colorectal cancer: a two-sample mendelian randomization study. | Liu C et al. | β | 2024 | β |
| Unravelling the Metabolic Underpinnings of Gestational Diabetes Mellitus: A Comprehensive Mendelian Randomisation Analysis Identifying Causal Metabolites and Biological Pathways. | Shen M et al. | β | 2024 | β |
| Unveiling the atlas of associations between 1,400 plasma metabolites and 24 tumors: Mendelian randomization analyses. | Zhang J et al. | β | 2024 | β |
| Unveiling the causal effects of gut microbiome on trimethylamine N-oxide: evidence from Mendelian randomization. | Yu Y et al. | β | 2024 | β |
| Unveiling the mystery: Investigating the debate surrounding mitochondrial DNA copy number and SjΓΆgren syndrome using Mendelian randomization analysis. | Zhou J et al. | β | 2024 | β |
| Unveiling the truth: Pathogen infections linked to miscarriage: A STROBE-Compliant Mendelian randomization study. | Zhou J et al. | β | 2024 | β |
| Using genetic variations to reveal the complex relationships between vegetarianism and well-being, depressive symptoms and neuroticism. | Chen K et al. | β | 2024 | β |
| Validation of TYK2 and exploration of PRSS36 as drug targets for psoriasis using Mendelian randomization. | Guo X et al. | β | 2024 | β |
| Vitamin D and Gestational Diabetes Mellitus in the IEU OpenGWAS Project: A Two-Sample Bidirectional Mendelian Randomization Study. | Bai Y et al. | β | 2024 | β |