Here we report a series of linkage and association analyses in the COGA sample to follow up the individual reports of linkage to alcohol dependence, conduct disorder, and suicide attempts previously reported on chromosome 2. First, we conducted linkage analyses that jointly consider the previously linked phenotypes in the COGA sample. We conducted these analyses using the high risk COGA family-based sample, in which both microsatellite [Reich, 1996] and SNP [Edenberg et al., 2005] linkage panels are available. Secondly, we tested for association with SNPs across chromosome 2 in a case–control sample, which included a subset of the alcohol-dependent probands from the linkage sample.
