Neurobehavior disinhibition in childhood predicts suicide potential and substance use disorder by young adulthood.
- Authors
- Tarter, R E; Kirisci, Levent; Reynolds, Maureen; Mezzich, Ada
- Year
- 2004
- Journal
- Drug and alcohol dependence
- PMID
- 15555816
- DOI
- 10.1016/j.drugalcdep.2004.08.006
The objectives of this study were to (a) determine whether two factors that are established components of the risk for substance use disorder (SUD) also impact on the risk for suicide; and (2) evaluate whether SUD manifest by early adulthood predicts suicide propensity. Neurobehavior disinhibition assessed in 227 boys at ages 10-12 and 16 and parental history of SUD were prospectively evaluated to determine their association with the risk for SUD and suicide propensity between ages 16 and 19. The results indicated that neurobehavior disinhibition at age 16 predicts suicide propensity between ages 16 and 19 (p = .04). A trend was observed (p = .08) for SUD manifest between ages 16 and 19 to predict suicide propensity during the same period. Maternal SUD is directly associated with son's SUD risk but not suicide propensity. Paternal SUD predicts son's neurobehavior disinhibition that, in turn, predisposes to SUD. A direct relation between paternal SUD and son's suicide propensity was not observed. These findings suggest that neurobehavior disinhibition, a component of the liability of SUD, is also associated with suicide risk. These results are discussed within a neurobehavioral framework in which prefrontal cortex dysfunction is hypothesized to underlie the risk for these two outcomes.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Abnormal ReHo and ALFF values in drug-naïve depressed patients with suicidal ideation or attempts: Evidence from the REST-meta-MDD consortium. | Luo G et al. | — | 2025 | → |
| Altered resting-state and dynamic functional connectivity of hypothalamic in first-episode depression: A functional magnetic resonance imaging study. | Xiao X et al. | — | 2024 | → |
| Association of Suicidal Status, Inflammation Markers and Resting State Functional Connectivity in Patients with Major Depressive Disorder | Olié E et al. | — | 2023 | — |
| Substance use disorder is the outcome of deviant socialization: A prospective investigation spanning childhood to adulthood. | Reynolds M et al. | — | 2023 | → |
| Active and Passive Attentional Processing in Adolescent Suicide Attempters: An Event-Related Potential Study. | Tavakoli P et al. | — | 2021 | → |
| Common and distinct neural connectivity in attention-deficit/hyperactivity disorder and alcohol use disorder studied using resting-state functional magnetic resonance imaging. | Farré-Colomés À et al. | — | 2021 | → |
| Altered Static and Dynamic Functional Connectivity of Habenula Associated With Suicidal Ideation in First-Episode, Drug-Naïve Patients With Major Depressive Disorder. | Qiao D et al. | — | 2020 | → |
| Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population. | Park CI et al. | — | 2020 | → |
| Onset Age of Substance Use and Neuropsychological Performance in Hospital Patients. | Höijer I et al. | — | 2020 | → |
| Transition to substance use disorders: impulsivity for reward and learning from reward. | Poulton A et al. | — | 2020 | → |
| Pharmacotherapeutic strategies for the treatment of attention-deficit hyperactivity (ADHD) disorder with comorbid substance-use disorder (SUD). | Perugi G et al. | — | 2019 | → |
| Childhood ADHD Symptoms and Future Illicit Drug Use: The Role of Adolescent Cigarette Use. | Lee CT et al. | — | 2018 | → |
| The effects of exposure to appetitive cues on inhibitory control: A meta-analytic investigation. | Jones A et al. | — | 2018 | → |
| Hierarchical investigation of genetic influences on response inhibition in healthy young adults. | Weafer J et al. | — | 2017 | → |
| Sleep, Affect, and Social Competence from Preschool to Preadolescence: Distinct Pathways to Emotional and Social Adjustment for Boys and for Girls. | Foley JE et al. | — | 2017 | → |
| Abnormal regional homogeneity in young adult suicide attempters with no diagnosable psychiatric disorder: a resting state functional magnetic imaging study. | Cao J et al. | — | 2015 | → |
| Child maltreatment and risk behaviors: The roles of callous/unemotional traits and conscientiousness. | Carlson M et al. | — | 2015 | → |
| Youth Whose Weight Exceeds Healthy Guidelines Are High-Risk Targets for Tobacco Prevention Messaging and Close Monitoring of Cigarette Use. | Zeller MH et al. | — | 2015 | → |
| Inhibition during early adolescence predicts alcohol and marijuana use by late adolescence. | Squeglia LM et al. | — | 2014 | → |
| Student assistance program outcomes for students at risk for suicide. | Biddle VS et al. | — | 2014 | → |
| Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors. | Kesler S et al. | — | 2013 | → |
| Fluctuating disinhibition: implications for the understanding and treatment of alcohol and other substance use disorders. | Jones A et al. | — | 2013 | → |
| Risk-taking behaviors of adolescents with extreme obesity: normative or not? | Ratcliff MB et al. | — | 2011 | → |
| Substance use/abuse and suicidal behavior in young adult women: a population-based study. | Sundin M et al. | — | 2011 | → |
| Cortical and subcortical abnormalities in late-onset depression with history of suicide attempts investigated with MRI and voxel-based morphometry. | Hwang JP et al. | — | 2010 | → |
| Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. | Dick DM et al. | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Infant neurobehavioral dysregulation: behavior problems in children with prenatal substance exposure. | Lester BM et al. | — | 2009 | → |
| Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults. | Walker QD et al. | — | 2009 | → |
| Suicide ideation among college students: a multivariate analysis. | Arria AM et al. | — | 2009 | → |
| Attention deficit in depressed suicide attempters. | Keilp JG et al. | — | 2008 | → |
| Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. | Verdejo-García A et al. | — | 2008 | → |