Drinking or abstaining at age 14? A genetic epidemiological study.
paper
Cited
Public
Unavailable
- Authors
- Rose, R J; Dick, D M; Viken, R J; Pulkkinen, L; Kaprio, J
- Year
- 2001
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 11707634
BACKGROUND: Regular drinking by age 14 years is a significant risk factor for alcoholism, and genetically informative data suggest that whether a young adolescent abstains or drinks is largely attributable to familial (or other shared) environmental factors. METHODS: Three consecutive birth cohorts of Finnish twins, enrolled into a longitudinal study at age 11 to 12 years, completed a follow-up questionnaire within 3 months of their 14th birthdays. The sample included 1380 twin sisters and 1330 twin brothers at age 14, and at that age, 35.4% reported using alcohol. Genetic analyses (model-fitting of twin pair data) and epidemiological analyses (logistical regressions of data from individual twins) were conducted to examine predictive factors of drinking versus abstinence at age 14. RESULTS: Polychoric correlations were substantial across all same-sex twin pairs but were lower for brother-sister twins, suggesting significant influences of common environments, with some sex-specific effects. Common environmental effects were equivalent in male and female adolescents and accounted for 76% of the total variation in abstinence/drinking. Logistical regression analyses among 2206 individual twins with complete data on risk-relevant measures at both baseline and follow-up identified significant predictors of drinking or abstaining at age 14, including female sex, twin sibling of the opposite sex, accelerated pubertal development, and the twins' assessments, made at age 12, of reduced parental monitoring and a less supportive home atmosphere; drinking at age 14 was also predicted by behaviors rated by the twins' classroom teachers 2 years earlier, increasing with rated behavioral problems but decreasing with rated emotional problems. CONCLUSIONS: Our results show that environmental factors shared by twin siblings account for most of the variance in abstaining or drinking at age 14. We identify predictors of drinking in the adolescent twins' home environments and in their dispositional behaviors, sibling interactions, and pubertal timing.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Self-regulation of socioemotional behavior in twin adolescents: Structural validation of a multidimensional inventory. | Pulkkinen L et al. | — | 2025 | → |
| Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study. | Gresko SA et al. | — | 2022 | → |
| Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. | Clarke TK et al. | — | 2021 | → |
| A review of psychosocial factors linked to adolescent substance use. | Trucco EM | — | 2020 | → |
| Frequent intoxication and alcohol tolerance in adolescence: associations with psychiatric disorders in young adulthood. | Sarala M et al. | — | 2020 | → |
| Prevalence patterns of alcohol consumption and factors associated with problematic drinking on remote islands of Okinawa, Japan: a cross-sectional study. | Mori H et al. | — | 2020 | → |
| Associations of Early Age of First Intoxication with Past Year Drinking Contexts and Problems. | Lipperman-Kreda S et al. | — | 2019 | → |
| Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood: a Finnish longitudinal twin study. | Virtanen S et al. | — | 2019 | → |
| FinnTwin12 Cohort: An Updated Review. | Rose RJ et al. | — | 2019 | → |
| Genetic and environmental influences on developmental trajectories of adolescent alcohol use. | Zheng Y et al. | — | 2019 | → |
| Protective Factors Buffer Life Stress and Behavioral Health Outcomes among High-Risk Youth. | Sharma S et al. | — | 2019 | → |
| The Impact of Genes on Adolescent Substance Use: A Developmental Perspective. | Trucco EM et al. | — | 2019 | → |
| Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention. | Cleveland HH et al. | — | 2018 | → |
| Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use. | Trucco EM et al. | — | 2018 | → |
| Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample. | Sartor CE et al. | — | 2018 | → |
| Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins. | Savage JE et al. | — | 2018 | → |
| Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. | Korhonen T et al. | — | 2018 | → |
| Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking. | Pascual M et al. | — | 2018 | → |
| Beyond risk: Prospective effects of GABA Receptor Subunit Alpha-2 (GABRA2) × Positive Peer Involvement on adolescent behavior. | Trucco EM et al. | — | 2017 | → |
| Predicting early onset of intoxication versus drinking-A population-based prospective study of Norwegian adolescents. | Enstad F et al. | — | 2017 | → |
| A Longitudinal Adoption Study of Substance Use Behavior in Adolescence. | Huibregtse BM et al. | — | 2016 | → |
| Genes involved in stress response and alcohol use among high-risk African American youth. | Goyal N et al. | — | 2016 | → |
| Genetic influences on adolescent behavior. | Dick DM et al. | — | 2016 | → |
| Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan. | Ting TT et al. | — | 2015 | → |
| Patterns of Substance Use Across the First Year of College and Associated Risk Factors. | Cho SB et al. | — | 2015 | → |
| Preventing alcohol use with a universal school-based intervention: results from an effectiveness study. | Strøm HK et al. | — | 2015 | → |
| Sibling Facilitation Mediates the Association Between Older and Younger Sibling Alcohol Use in Late Adolescence. | Samek DR et al. | — | 2015 | → |
| A multivariate twin study of the dimensions of religiosity and common psychiatric and substance use disorders. | Vance T et al. | — | 2014 | → |
| Associations between sexual abstinence ideals, religiosity, and alcohol abstinence: a longitudinal study of Finnish twins. | Winter T et al. | — | 2014 | → |
| Childhood verbal development and drinking behaviors from adolescence to young adulthood: a discordant twin-pair analysis. | Latvala A et al. | — | 2014 | → |
| Early drinking onset: a study of prevalence and determinants among 13-year-old adolescents in Norway. | Adolfsen F et al. | — | 2014 | → |
| Genetic and environmental influences on the ages of drinking and gambling initiation: evidence for distinct aetiologies and sex differences. | Richmond-Rakerd LS et al. | — | 2014 | → |
| Genetic influences on alcohol use behaviors have diverging developmental trajectories: a prospective study among male and female twins. | Meyers JL et al. | — | 2014 | → |
| Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse. | Trucco EM et al. | — | 2014 | → |
| Adolescent alcohol use is predicted by childhood temperament factors before age 5, with mediation through personality and peers. | Dick DM et al. | — | 2013 | → |
| Developmental differences in EEG and sleep responses to acute ethanol administration and its withdrawal (hangover) in adolescent and adult Wistar rats. | Ehlers CL et al. | — | 2013 | → |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | — | 2013 | → |
| Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. | Bardo MT et al. | — | 2013 | → |
| Peer deviance, alcohol expectancies, and adolescent alcohol use: explaining shared and nonshared environmental effects using an adoptive sibling pair design. | Samek DR et al. | — | 2013 | → |
| Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents. | Miranda R et al. | — | 2013 | → |
| Differences in the impact of the frequency and enjoyment of joint family activities on adolescent substance use and violence. | Windlin B et al. | — | 2012 | → |
| Environmental influences predominate in remission from alcohol use disorder in young adult twins. | McCutcheon VV et al. | — | 2012 | → |
| Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers. | Kalu N et al. | — | 2012 | → |
| Trends in adolescent alcohol use: effects of age, sex and cohort on prevalence and heritability. | Geels LM et al. | — | 2012 | → |
| Childhood risk factors for early-onset drinking. | Donovan JE et al. | — | 2011 | → |
| Early environmental influences contribute to covariation between internalizing symptoms and alcohol intoxication frequency across adolescence. | Edwards AC et al. | — | 2011 | → |
| Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. | Dong L et al. | — | 2011 | → |
| Heritability of smoking, alcohol use, and psychological characteristics among adolescent twins in Qingdao, China. | Unger JB et al. | — | 2011 | → |
| Prospective relationships of ADHD symptoms with developing substance use in a population-derived sample. | Sihvola E et al. | — | 2011 | → |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | — | 2010 | → |
| Does religious involvement protect against early drinking? A behavior genetic approach. | Harden KP | — | 2010 | → |
| Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats. | Criado JR et al. | — | 2010 | → |
| Examining the etiology of associations between perceived parenting and adolescents' alcohol use: common genetic and/or environmental liabilities? | Latendresse SJ et al. | — | 2010 | → |
| Genetic and environmental risk factors for adolescent-onset substance use disorders. | Meyers JL et al. | — | 2010 | → |
| Genetic Thinking in the Study of Social Relationships: Five Points of Entry. | Reiss D | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Parental support and knowledge and adolescents' sexual health: testing two mediational models in a national Dutch sample. | de Graaf H et al. | — | 2010 | → |
| Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. | Young SE et al. | — | 2009 | → |
| Developmental processes and mechanisms: ages 0-10. | Zucker RA et al. | — | 2009 | → |
| Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use. | Rende R et al. | — | 2009 | → |
| Prospective associations of early-onset Axis I disorders with developing eating disorders. | Sihvola E et al. | — | 2009 | → |
| Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. | Dick DM et al. | — | 2009 | → |
| Sibling Contagion for Drinking in Adolescence: A Micro Process Framework. | Slomkowski C et al. | — | 2009 | → |
| The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. | Dick DM et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| A developmental approach to alcohol drinking behaviour in adulthood: a follow-up study from age 8 to age 42. | Pitkänen T et al. | — | 2008 | → |
| A retrospective sibling study of childhood adjustment in adults with substance use disorders. | Easow JM et al. | — | 2008 | → |
| Early developmental processes and the continuity of risk for underage drinking and problem drinking. | Zucker RA et al. | — | 2008 | → |
| Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins. | Sihvola E et al. | — | 2008 | → |
| Electrophysiological effects of dizocilpine (MK-801) in adult rats exposed to ethanol during adolescence. | Criado JR et al. | — | 2008 | → |
| Environmental factors as predictors of alcohol use among ninth-grade adolescents in Pitkaranta (Russian Karelia) and in eastern Finland. | Kemppainen U et al. | — | 2008 | → |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | — | 2008 | → |
| Parental supervision and alcohol use in adolescence: developmentally specific interactions. | Clark DB et al. | — | 2008 | → |
| Parenting mechanisms in links between parents' and adolescents' alcohol use behaviors. | Latendresse SJ et al. | — | 2008 | → |
| Role of individual, peer and family factors in the use of cannabis and other illicit drugs: a longitudinal analysis among Finnish adolescent twins. | Korhonen T et al. | — | 2008 | → |
| The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking? | Poelen EA et al. | — | 2008 | → |
| Changing environmental influences on substance use across development. | Dick DM et al. | — | 2007 | → |
| Gender differences in friends' influences on adolescent drinking: a genetic epidemiological study. | Dick DM et al. | — | 2007 | → |
| Minor depression in adolescence: phenomenology and clinical correlates. | Sihvola E et al. | — | 2007 | → |
| Patterns and correlates of drinking in offspring from the San Diego Prospective Study. | Schuckit MA et al. | — | 2007 | → |
| Personality at ages 16 and 17 and drinking problems at ages 18 and 25: genetic analyses of data from Finn Twin16-25. | Viken RJ et al. | — | 2007 | → |
| Sexual behavior in young adulthood: a population-based twin study. | Mustanski B et al. | — | 2007 | → |
| Alcohol use in families: a 15-year prospective follow-up study. | Seljamo S et al. | — | 2006 | → |
| Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. | Dick DM et al. | — | 2006 | → |
| [Factors influencing juvenile alcohol consumption: the role of gene-environment interactions]. | Hinckers AS et al. | — | 2006 | → |
| Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. | Pagan JL et al. | — | 2006 | → |
| Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific? | Young SE et al. | — | 2006 | → |
| Genetic epidemiology of cannabis use, abuse and dependence: a comment on Agrawal and Lynskey (2006). | Kaprio J | — | 2006 | → |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | — | 2006 | → |
| The association of early adolescent problem behavior and adult psychopathology: a multivariate behavioral genetic perspective. | McGue M et al. | — | 2006 | → |
| The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. | Dick DM et al. | — | 2006 | → |
| The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. | Dick DM et al. | — | 2006 | → |
| Age of onset of drinking and the use of alcohol in adulthood: a follow-up study from age 8-42 for females and males. | Pitkänen T et al. | — | 2005 | → |
| Co-twin dependence modifies heritability of abstinence and alcohol use: a population-based study of Finnish twins. | Penninkilampi-Kerola V et al. | — | 2005 | → |
| Testosterone and alcohol use among adolescent male twins: testing between-family associations in within-family comparisons. | Eriksson CJ et al. | — | 2005 | → |
| The development of alcohol use disorders. | Sher KJ et al. | — | 2005 | → |
| Childhood externalizing and internalizing psychopathology in the prediction of early substance use. | King SM et al. | — | 2004 | → |
| Comparison of the onset of hypoactivity and anxiety-like behavior during alcohol withdrawal in adolescent and adult rats. | Slawecki CJ et al. | — | 2004 | → |
| Genetic and environmental effects on conduct disorder and alcohol dependence symptoms and their covariation at age 14. | Rose RJ et al. | — | 2004 | → |
| Genetic and environmental influences on pubertal development: longitudinal data from Finnish twins at ages 11 and 14. | Mustanski BS et al. | — | 2004 | → |
| Identifying shared environmental contributions to early substance use: the respective roles of peers and parents. | Walden B et al. | — | 2004 | → |
| Inattentiveness, parental smoking and adolescent smoking initiation. | Barman SK et al. | — | 2004 | → |
| The natural history of adolescent alcohol use disorders. | Clark DB | — | 2004 | → |
| Breakfast skipping and health-compromising behaviors in adolescents and adults. | Keski-Rahkonen A et al. | — | 2003 | → |
| It does take a village: nonfamilial environments and children's behavior. | Rose RJ et al. | — | 2003 | → |
| Review of twin and adoption studies of adolescent substance use. | Hopfer CJ et al. | — | 2003 | → |
| Etiology of adolescent substance abuse: a developmental perspective. | Tarter RE | — | 2002 | → |
| Femininity and fertility in sisters with twin brothers: prenatal androgenization? Cross-sex socialization? | Rose RJ et al. | — | 2002 | → |
| The heritability of depressive symptoms: multiple informants and multiple measures. | Happonen M et al. | — | 2002 | → |