Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
- Authors
- Rangaswamy, Madhavi; Porjesz, Bernice
- Year
- 2008
- Journal
- Brain research
- PMID
- 18634760
- DOI
- 10.1016/j.brainres.2008.06.053
- PMCID
- PMC2814598
Brain oscillations provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as they represent important correlates of human information processing and are associated with fundamental processes from perception to cognition. These oscillations are highly heritable, are modulated by genes controlling neurotransmitters in the brain, and provide links to associative and integrative brain functions. These endophenotypes represent traits that are less complex and more proximal to gene function than either diagnostic labels or traditional cognitive measures, providing a powerful strategy in searching for genes in psychiatric disorders. These intermediate phenotypes identify both affected and unaffected members of an affected family, including offspring at risk, providing a more direct connection with underlying biological vulnerability. Our group has utilized heritable neurophysiological features (i.e., brain oscillations) as endophenotypes, making it possible to identify susceptibility genes that may be difficult to detect with diagnosis alone. We have discussed our findings of significant linkage and association between brain oscillations and genes in GABAergic, cholinergic and glutamatergic systems (GABRA2, CHRM2, and GRM8). We have also shown that some oscillatory indices from both resting and active cognitive states have revealed a common subset of genetic foci that are shared with the diagnosis of alcoholism and related disorders. Implications of our findings have been discussed in the context of physiological and pharmacological studies on receptor function. These findings underscore the utility of quantitative neurophysiological endophenotypes in the study of the genetics of brain function and the genetic diathesis underlying complex psychiatric disorders.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Sleep phenotyping in a rat model of susceptibility to substance use disorders. | FiciarΓ E et al. | β | 2025 | β |
| Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms. | Neale ZE et al. | β | 2024 | β |
| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | β | 2023 | β |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | β | 2023 | β |
| A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior. | Meyers JL et al. | β | 2021 | β |
| EEG, MEG and neuromodulatory approaches to explore cognition: Current status and future directions. | Beppi C et al. | β | 2021 | β |
| Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. | Smit DJA et al. | β | 2021 | β |
| Rich Club Characteristics of Alcohol-NaΓ―ve Functional Brain Networks Predict Future Drinking Phenotypes in Rhesus Macaques. | Rowland JA et al. | β | 2021 | β |
| Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach. | Correas A et al. | β | 2019 | β |
| High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults. | Affan RO et al. | β | 2018 | β |
| Human Genomic Signatures of Brain Oscillations During Memory Encoding. | Berto S et al. | β | 2018 | β |
| P3 Component as a Potential Endophenotype for Control Inhibition in Offspring of Alcoholics. | DomΓnguez-Centeno I et al. | β | 2018 | β |
| Genetic correlates of the development of theta event related oscillationsΒ in adolescents and young adults. | Chorlian DB et al. | β | 2017 | β |
| African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. | Levran O et al. | β | 2016 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Disentangling the impacts of outcome valence and outcome frequency on the post-error slowing. | Wang L et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Gender modulates the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | β | 2015 | β |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | β | 2015 | β |
| Does electroencephalogram phase variability account for reduced P3 brain potential in externalizing disorders? | Burwell SJ et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants. | Hall MH et al. | β | 2014 | β |
| Oscillatory spatial profile of alcohol's effects on the resting state: anatomically-constrained MEG. | Rosen BQ et al. | β | 2014 | β |
| The 5-HT7 receptor as a potential target for treating drug and alcohol abuse. | Hauser SR et al. | β | 2014 | β |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | β | 2014 | β |
| Brain oscillations as biomarkers in neuropsychiatric disorders: following an interactive panel discussion and synopsis. | Yener GG et al. | β | 2013 | β |
| Executive functions in adult offspring of alcohol-dependent probands: toward a cognitive endophenotype? | Gierski F et al. | β | 2013 | β |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | β | 2013 | β |
| Global organization of functional brain connectivity in methamphetamine abusers. | Ahmadlou M et al. | β | 2013 | β |
| The role of rs2237781 within GRM8 in eating behavior. | Gast MT et al. | β | 2013 | β |
| Brain rhythms and neural syntax: implications for efficient coding of cognitive content and neuropsychiatric disease. | BuzsΓ‘ki G et al. | β | 2012 | β |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | β | 2012 | β |
| Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders. | Criado JR et al. | β | 2012 | β |
| Family-based genome-wide association study of frontal ΞΈ oscillations identifies potassium channel gene KCNJ6. | Kang SJ et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| Theta oscillations are sensitive to both early and late conflict processing stages: effects of alcohol intoxication. | Kovacevic S et al. | β | 2012 | β |
| Alcohol research: past, present, and future. | Gunzerath L et al. | β | 2011 | β |
| Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior. | Latendresse SJ et al. | β | 2011 | β |
| Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder. | Cannon DM et al. | β | 2011 | β |
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | Zlojutro M et al. | β | 2011 | β |
| A new role for endophenotypes in the GWAS era: functional characterization of risk variants. | Hall MH et al. | β | 2010 | β |
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | Kamarajan C et al. | β | 2010 | β |
| Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats. | Criado JR et al. | β | 2010 | β |
| Event-related oscillations in the parietal cortex of adult alcohol-preferring (P) and alcohol-nonpreferring rats (NP). | Criado JR et al. | β | 2010 | β |
| Neurofeedback Effects on Evoked and Induced EEG Gamma Band Reactivity to Drug-related Cues in Cocaine Addiction. | Horrell T et al. | β | 2010 | β |
| Event-related oscillations as risk markers in genetic mouse models of high alcohol preference. | Criado JR et al. | β | 2009 | β |
| A review of brain oscillations in cognitive disorders and the role of neurotransmitters. | BaΕar E et al. | β | 2008 | β |
| Oscillations in "brain-body-mind"--a holistic view including the autonomous system. | BaΕar E | β | 2008 | β |