Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat.
paper
Cited
Public
Unavailable
- Authors
- Pascual, Maria; Boix, Jordi; Felipo, Vicente; Guerri, Consuelo
- Year
- 2009
- Journal
- Journal of neurochemistry
- PMID
- 19077056
- DOI
- 10.1111/j.1471-4159.2008.05835.x
Adolescence is a developmental period which the risk of drug and alcohol abuse increases. Since mesolimbic dopaminergic system undergoes developmental changes during adolescence, and this system is involved in rewarding effects of drugs of abuse, we addressed the hypothesis that ethanol exposure during juvenile/adolescent period over-activates mesolimbic dopaminergic system inducing adaptations which can trigger long-term enduring behavioural effects of alcohol abuse. We treated juvenile/adolescent or adult rats with ethanol (3 g/kg) for two-consecutive days at 48-h intervals over 14-day period. Here we show that intermittent ethanol treatment during the juvenile/adolescence period alters subsequent ethanol intake. In vivo microdialysis demonstrates that ethanol elicits a similar prolonged dopamine response in the nucleus accumbens of both adolescent and adult animals pre-treated with multiple doses of ethanol, although the basal dopamine levels were higher in ethanol-treated adolescents than in adult-treated animals. Repeated ethanol administration also down-regulates the expression of DRD2 and NMDAR2B phosphorylation in prefrontal cortex of adolescent animals, but not of adult rats. Finally, ethanol treatment during adolescence changes the acetylation of histones H3 and H4 in frontal cortex, nucleus accumbens and striatum, suggesting chromatin remodelling changes. In summary, our findings demonstrate the sensitivity of adolescent brain to ethanol effects on dopaminergic and glutamatergic neurotransmission, and suggest that abnormal plasticity in reward-related processes and epigenetic mechanisms could contribute to the vulnerability of adolescents to alcohol addiction.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Impact of Neuroimmune System Activation by Adolescent Binge Alcohol Exposure on Adult Neurobiology. | Macht V et al. | β | 2025 | β |
| The Dopamine System in Mediating Alcohol Effects in Humans. | Beck A et al. | β | 2025 | β |
| The interplay between gut microbiome, epigenetics, and substance use disorders: from molecular to clinical perspectives. | Sahebi K et al. | β | 2025 | β |
| The link between early-life adversity and later alcohol use disorder: A role for microglia? | Lichtenstein HD et al. | β | 2025 | β |
| Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice. | Davidson CJ et al. | β | 2024 | β |
| Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats. | Pochapski JA et al. | β | 2024 | β |
| Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development. | Brocato ER et al. | β | 2024 | β |
| Effects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats. | Shaykin JD et al. | β | 2024 | β |
| Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal. | Wani SN et al. | β | 2024 | β |
| Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD. | Crews FT et al. | β | 2024 | β |
| The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders. | Fanfarillo F et al. | β | 2024 | β |
| Adolescent alcohol and nicotine exposure alters the adult response to alcohol use. | Hauser SR et al. | β | 2023 | β |
| Adolescent Intermittent Ethanol Drives Modest Neuroinflammation but Does Not Escalate Drinking in Male Rats. | Wooden JI et al. | β | 2023 | β |
| A review on the reciprocal interactions between neuroinflammatory processes and substance use and misuse, with a focus on alcohol misuse. | Gano A et al. | β | 2023 | β |
| Binge eating promotes ethanol self-administration in female rats with a history of intermittent ethanol exposure at adolescence. | Leyva LR et al. | β | 2023 | β |
| Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking Β adolescent rats. Focus on calcitonin gene-related peptide's brain levels. | Tringali G et al. | β | 2023 | β |
| Differential consumption of alcohol, caffeine, and caffeinated alcohol by adolescent rats, and effects on post-adolescent gene expression signatures in the nucleus accumbens and orbitofrontal cortex. | Thompson SM et al. | β | 2023 | β |
| Longitudinal associations between age 20 problematic substance use and opioid use disorder incidence at age 30 - findings from an urban cohort. | Thrul J et al. | β | 2023 | β |
| Sex-specific decision-making impairments and striatal dopaminergic changes after binge drinking history in rats. | Sauton P et al. | β | 2023 | β |
| Targeting Persistent Changes in Neuroimmune and Epigenetic Signaling in Adolescent Drinking to Treat Alcohol Use Disorder in Adulthood. | Crews FT et al. | β | 2023 | β |
| Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice. | Maldonado-Devincci AM et al. | β | 2022 | β |
| Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review. | Kuhns L et al. | β | 2022 | β |
| Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage. | Nakayama K et al. | β | 2022 | β |
| Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats. | Atrooz F et al. | β | 2022 | β |
| Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats. | Chandler CM et al. | β | 2022 | β |
| Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens. | Anderson EM et al. | β | 2022 | β |
| Maternal immune activation and adolescent alcohol exposure increase alcohol drinking and disrupt cortical-striatal-hippocampal oscillations in adult offspring. | Henricks AM et al. | β | 2022 | β |
| Maternal immune activation and adolescent alcohol exposure increases alcohol drinking and disrupts cortical-striatal-hippocampal oscillations in adult offspring | Henricks AM et al. | β | 2022 | β |
| Negative and positive allosteric modulators of the Ξ±7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption. | Rodd ZA et al. | β | 2022 | β |
| Repeated Cycles of Binge-Like Ethanol Exposure Induces Neurobehavioral Changes During Short- and Long-Term Withdrawal in Adolescent Female Rats. | Queiroz LY et al. | β | 2022 | β |
| The Role of the Adenosine System on Emotional and Cognitive Disturbances Induced by Ethanol Binge Drinking in the Immature Brain and the Beneficial Effects of Caffeine. | Pinheiro BG et al. | β | 2022 | β |
| Voluntary Adolescent-Onset Alcohol Drinking Fails to Influence Alcohol Consumption or Anxiety-Like Behaviour in Adulthood in Female Alcohol-Preferring Rats. | Mugantseva E et al. | β | 2022 | β |
| Acute depletion of dopamine precursors in the human brain: effects on functional connectivity and alcohol attentional bias. | Elton A et al. | β | 2021 | β |
| Adolescent Intermittent Ethanol (AIE) Enhances the Dopaminergic Response to Ethanol within the Mesolimbic Pathway during Adulthood: Alterations in Cholinergic/Dopaminergic Genes Expression in the Nucleus Accumbens Shell. | Hauser SR et al. | β | 2021 | β |
| Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters. | Dannenhoffer CA et al. | β | 2021 | β |
| Adolescent oxycodone exposure inhibits withdrawal-induced expression of genes associated with the dopamine transmission. | Carpenter MD et al. | β | 2021 | β |
| Astroglia in the Vulnerability and Maintenance of Alcohol Use Disorders. | Miguel-Hidalgo JJ | β | 2021 | β |
| Binge ethanol consumption-associated behavioral impairments in male mice using a gelatin-based drinking-in-the dark model. | Rath M et al. | β | 2021 | β |
| CXCR4 inhibition with AMD3100 attenuates amphetamine induced locomotor activity in adolescent Long Evans male rats. | Mason B et al. | β | 2021 | β |
| Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats. | Hamidullah S et al. | β | 2021 | β |
| Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. | Lim Y et al. | β | 2021 | β |
| Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice. | GonzΓ‘lez-Portilla M et al. | β | 2021 | β |
| The effects of peri-adolescent alcohol use on the developing hippocampus. | Walker CD et al. | β | 2021 | β |
| The effects of voluntary adolescent alcohol consumption on alcohol taste reactivity in Long Evans rats. | Wukitsch TJ et al. | β | 2021 | β |
| The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle. | Siomek-Gorecka A et al. | β | 2021 | β |
| The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathology: A role for the neuroimmune system and epigenetics. | Coleman LG et al. | β | 2021 | β |
| The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents. | Robinson DL et al. | β | 2021 | β |
| The role of the orbitofrontal cortex and the nucleus accumbens for craving in alcohol use disorder. | Bracht T et al. | β | 2021 | β |
| Aberrations in Incentive Learning and Responding to Heroin in Male Rats After Adolescent or Adult Chronic Binge-Like Alcohol Exposure. | Galaj E et al. | β | 2020 | β |
| Adolescent ethanol exposure and differential rearing environment affect taste reactivity to ethanol in rats. | Wukitsch TJ et al. | β | 2020 | β |
| Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity. | Towner TT et al. | β | 2020 | β |
| Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences. | Thorpe HHA et al. | β | 2020 | β |
| Adolescent Vulnerability to Alcohol Use Disorder: Neurophysiological Mechanisms from Preclinical Studies. | McCool BA et al. | β | 2020 | β |
| Argan oil supplementation attenuates voluntary ethanol consumption and withdrawal syndrome promoted by adolescent intermittent ethanol in rat. | El Mostafi H et al. | β | 2020 | β |
| Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking. | Salguero A et al. | β | 2020 | β |
| Chronic Ethanol Exposure during Adolescence Increases Voluntary Ethanol Consumption in Adulthood in Female Sprague Dawley Rats. | Maldonado-Devincci AM et al. | β | 2020 | β |
| Effects of Ethanol Exposure During Adolescence or Adulthood on Locomotor Sensitization and Dopamine Levels in the Reward System. | Carrara-Nascimento PF et al. | β | 2020 | β |
| Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1Ξ² signaling. | Akter S et al. | β | 2020 | β |
| Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function. | Coker CR et al. | β | 2020 | β |
| Molecular Structure, Binding Affinity, and Biological Activity in the Epigenome. | ZsidΓ³ BZ et al. | β | 2020 | β |
| Preclinical methodological approaches investigating of the effects of alcohol on perinatal and adolescent neurodevelopment. | Bailey CDC et al. | β | 2020 | β |
| The effects of social instability stress and subsequent ethanol consumption in adolescence on brain and behavioral development in male rats. | Marcolin ML et al. | β | 2020 | β |
| The structural reorganization of the prefrontal cortex during adolescence as a framework for vulnerability to the environment. | Drzewiecki CM et al. | β | 2020 | β |
| When Two Wrongs Make a Right: The Effect of Acute and Chronic Binge Drinking on Traumatic Brain Injury Outcomes in Young Adult Female Rats. | Christensen J et al. | β | 2020 | β |
| Adolescent Intermittent Ethanol Increases the Sensitivity to the Reinforcing Properties of Ethanol and the Expression of Select Cholinergic and Dopaminergic Genes within the Posterior Ventral Tegmental Area. | Hauser SR et al. | β | 2019 | β |
| Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking. | Sakharkar AJ et al. | β | 2019 | β |
| Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents. | Camarini R et al. | β | 2019 | β |
| Emotional Reactivity to Incentive Downshift in Adult Rats Exposed to Binge-Like Ethanol Exposure During Adolescence. | Lerma-Cabrera JM et al. | β | 2019 | β |
| Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus. | Li Q et al. | β | 2019 | β |
| Face validity of a pre-clinical model of operant binge drinking: just a question of speed. | Jeanblanc J et al. | β | 2019 | β |
| Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation. | Cantacorps L et al. | β | 2019 | β |
| Mechanisms of Persistent Neurobiological Changes Following Adolescent Alcohol Exposure: NADIA Consortium Findings. | Crews FT et al. | β | 2019 | β |
| MicroRNA-137 Drives Epigenetic Reprogramming in the Adult Amygdala and Behavioral Changes after Adolescent Alcohol Exposure. | Kyzar EJ et al. | β | 2019 | β |
| Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to Ξ±7 nicotinic acetylcholine receptor expression. | Waeiss RA et al. | β | 2019 | β |
| Persistent Alterations of Accumbal Cholinergic Interneurons and Cognitive Dysfunction after Adolescent Intermittent Ethanol Exposure. | Galaj E et al. | β | 2019 | β |
| The effects of sub-anesthetic ketamine plus ethanol on behaviors and apoptosis in the prefrontal cortex and hippocampus of adolescent rats. | Li Q et al. | β | 2019 | β |
| Voluntary alcohol access during adolescence/early adulthood, but not during adulthood, causes faster omission contingency learning. | Pickens CL et al. | β | 2019 | β |
| Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. | Zhang H et al. | β | 2018 | β |
| Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats. | Ruiz P et al. | β | 2018 | β |
| Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. | Jacobsen JHW et al. | β | 2018 | β |
| Binge Drinking's Effects on the Developing Brain-Animal Models. | Hiller-SturmhΓΆfel S et al. | β | 2018 | β |
| Effects of adolescent alcohol consumption on the brain and behaviour. | Spear LP | β | 2018 | β |
| Effects of adolescent alcohol exposure on stress-induced reward deficits, brain CRF, monoamines and glutamate in adult rats. | Boutros N et al. | β | 2018 | β |
| Forced ethanol ingestion by Wistar rats from a juvenile age increased voluntary alcohol consumption in adulthood, with the involvement of orexin-A. | Mendoza-Ruiz LG et al. | β | 2018 | β |
| Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens. | GimΓ©nez-GΓ³mez P et al. | β | 2018 | β |
| Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat. | Zhao Q et al. | β | 2018 | β |
| Oral Binge-Like Ethanol Pre-Exposure During Juvenile/Adolescent Period Attenuates Ethanol-Induced Conditioned Place Aversion in Rats. | Williams KL et al. | β | 2018 | β |
| Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking. | Pascual M et al. | β | 2018 | β |
| Transcriptional Regulators as Targets for Alcohol Pharmacotherapies. | Savarese AM et al. | β | 2018 | β |
| Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders. | Moaddab M et al. | β | 2017 | β |
| Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood. | Kyzar EJ et al. | β | 2017 | β |
| Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood. | Kokare DM et al. | β | 2017 | β |
| Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise. | Vetreno RP et al. | β | 2017 | β |
| Binge ethanol drinking during adolescence modifies cocaine responses in mice. | Esteve-Arenys A et al. | β | 2017 | β |
| Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood. | Varlinskaya EI et al. | β | 2017 | β |
| Conditioned effects of ethanol on the immune system. | Gano A et al. | β | 2017 | β |
| Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice. | Blanco-GandΓa MC et al. | β | 2017 | β |
| Emerging Role of Epigenetic Mechanisms in Alcohol Addiction. | Berkel TD et al. | β | 2017 | β |
| Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation. | Parira T et al. | β | 2017 | β |
| Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention. | Dir AL et al. | β | 2017 | β |
| Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats. | Marco EM et al. | β | 2017 | β |
| Long-term ethanol self-administration induces ΞFosB in male and female adolescent, but not in adult, Wistar rats. | Wille-Bille A et al. | β | 2017 | β |
| Maladaptive Decision Making in Adults with a History of Adolescent Alcohol use, in a Preclinical Model, Is Attributable to the Compromised Assignment of Incentive Value during Stimulus-Reward Learning. | Kruse LC et al. | β | 2017 | β |
| New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis. | Orellana JA et al. | β | 2017 | β |
| Nicotine Increases Alcohol Intake in Adolescent Male Rats. | LΓ‘rraga A et al. | β | 2017 | β |
| Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. | Parira T et al. | β | 2017 | β |
| Nucleus Accumbens MC4-R Stimulation Reduces Food and Ethanol Intake in Adult Rats Regardless of Binge-Like Ethanol Exposure during Adolescence. | Carvajal F et al. | β | 2017 | β |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | β | 2017 | β |
| Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach. | Madayag AC et al. | β | 2017 | β |
| Sex differences in the behavioral sequelae of chronic ethanol exposure. | Jury NJ et al. | β | 2017 | β |
| The Transitional Age Brain: "The Best of Times and the Worst of Times". | Chung WW et al. | β | 2017 | β |
| Traumatic brain injuries during development disrupt dopaminergic signaling. | Karelina K et al. | β | 2017 | β |
| Adolescent Alcohol Exposure: Burden of Epigenetic Reprogramming, Synaptic Remodeling, and Adult Psychopathology. | Kyzar EJ et al. | β | 2016 | β |
| Adolescent alcohol exposure decreased sensitivity to nicotine in adult Wistar rats. | Boutros N et al. | β | 2016 | β |
| Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. | Crews FT et al. | β | 2016 | β |
| Alcohol abuse after traumatic brain injury: Experimental and clinical evidence. | Weil ZM et al. | β | 2016 | β |
| Alcohol Induces Parallel Changes in Hippocampal Histone H3 Phosphorylation and c-Fos Protein Expression in Male Rats. | McClain JA et al. | β | 2016 | β |
| A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. | Sakharkar AJ et al. | β | 2016 | β |
| Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression. | Camarini R et al. | β | 2016 | β |
| Binge drinking impacts dorsal striatal response during decision making in adolescents. | Jones SA et al. | β | 2016 | β |
| Chronic cocaine exposure induces noradrenergic modulation of inhibitory synaptic transmission to cholinergic neurons of the laterodorsal tegmental nucleus. | Taoka N et al. | β | 2016 | β |
| Consequences of adolescent use of alcohol and other drugs: Studies using rodent models. | Spear LP | β | 2016 | β |
| Epigenetic and gene expression changes in the adolescent brain: What have we learned from animal models? | Mychasiuk R et al. | β | 2016 | β |
| Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets. | Jangra A et al. | β | 2016 | β |
| Exposure to alcohol during adolescence exerts long-term effects on stress response and the adult brain stress circuits. | Allen CD et al. | β | 2016 | β |
| Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence. | Montesinos J et al. | β | 2016 | β |
| Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice. | Weil ZM et al. | β | 2016 | β |
| Maternal separation and early stress cause long-lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats. | Romano-LΓ³pez A et al. | β | 2016 | β |
| Mechanisms of neuroimmune gene induction in alcoholism. | Crews FT et al. | β | 2016 | β |
| A Comprehensive View of the Neurotoxicity Mechanisms of Cocaine and Ethanol. | Pereira RB et al. | β | 2015 | β |
| Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat. | Liu W et al. | β | 2015 | β |
| Adolescent rats are resistant to the development of ethanol-induced chronic tolerance and ethanol-induced conditioned aversion. | Pautassi RM et al. | β | 2015 | β |
| Alcohol gains access to appetitive learning through adolescent heavy drinking. | DiLeo A et al. | β | 2015 | β |
| CaMKIIΞ±-GluA1 Activity Underlies Vulnerability to Adolescent Binge Alcohol Drinking. | Agoglia AE et al. | β | 2015 | β |
| Impact of adolescent ethanol exposure and adult amphetamine self-administration on evoked striatal dopamine release in male rats. | Granholm L et al. | β | 2015 | β |
| Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation. | Blum K et al. | β | 2015 | β |
| Neuroimaging of the dopamine/reward system in adolescent drug use. | Ernst M et al. | β | 2015 | β |
| Personality and Alcohol Expectancies Discriminate Alcohol Consumption Patterns in Female College Students. | Pilatti A et al. | β | 2015 | β |
| Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. | Pandey SC et al. | β | 2015 | β |
| Reduced cerebellar brain activity during reward processing in adolescent binge drinkers. | Cservenka A et al. | β | 2015 | β |
| Reduced dopamine release in the nucleus accumbens core of adult rats following adolescent binge alcohol exposure: age and dose-dependent analysis. | Zandy SL et al. | β | 2015 | β |
| Sex differences in the long-lasting consequences of adolescent ethanol exposure for the rewarding effects of cocaine in mice. | Mateos-GarcΓa A et al. | β | 2015 | β |
| The early origins of food preferences: targeting the critical windows of development. | Gugusheff JR et al. | β | 2015 | β |
| The quinoline compound, S4 effectively antagonizes alcohol intake in mice: Possible association with the histone H3 modifications. | Banerjee TS et al. | β | 2015 | β |
| The reinforcing properties of ethanol are quantitatively enhanced inΒ adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats. | Toalston JE et al. | β | 2015 | β |
| Two Binges of Ethanol a Day Keep the Memory Away in Adolescent Rats: Key Role for GLUN2B Subunit. | Silvestre de Ferron B et al. | β | 2015 | β |
| Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood. | Boutros N et al. | β | 2014 | β |
| Adolescent intermittent ethanol exposure is associated with increased risky choice and decreased dopaminergic and cholinergic neuron markers in adult rats. | Boutros N et al. | β | 2014 | β |
| Adolescents and alcohol: acute sensitivities, enhanced intake, and later consequences. | Spear LP | β | 2014 | β |
| Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats. | Fabio MC et al. | β | 2014 | β |
| Chronic intermittent ethanol exposure during adolescence: effects on social behavior and ethanol sensitivity in adulthood. | Varlinskaya EI et al. | β | 2014 | β |
| Chronic intermittent toluene inhalation initiated during adolescence in rats does not alter voluntary consumption of ethanol in adulthood. | Dick AL et al. | β | 2014 | β |
| Consequences of adolescent or adult ethanol exposure on tone and context fear retention: effects of an acute ethanol challenge during conditioning. | Broadwater M et al. | β | 2014 | β |
| Contribution of time of drinking onset and family history of alcohol problems in alcohol and drug use behaviors in Argentinean college students. | Pilatti A et al. | β | 2014 | β |
| Dopamine release dynamics change during adolescence and after voluntary alcohol intake. | Palm S et al. | β | 2014 | β |
| Effects of ethanol exposure during adolescence or in adulthood on Pavlovian conditioned approach in Sprague-Dawley rats. | McClory AJ et al. | β | 2014 | β |
| Effects of ethanol on immune response in the brain: region-specific changes in adolescent versus adult mice. | Kane CJ et al. | β | 2014 | β |
| Effects of the abused inhalant toluene on the mesolimbic dopamine system. | Woodward JJ et al. | β | 2014 | β |
| Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. | Morales M et al. | β | 2014 | β |
| Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. | Qiang M et al. | β | 2014 | β |
| Epigenetic signaling in psychiatric disorders. | PeΓ±a CJ et al. | β | 2014 | β |
| Ethanol reduces evoked dopamine release and slows clearance in the rat medial prefrontal cortex. | Shnitko TA et al. | β | 2014 | β |
| Higher long-lasting ethanol sensitization after adolescent ethanol exposure in mice. | Quoilin C et al. | β | 2014 | β |
| Histone acetylation in the nucleus accumbens shell modulates ethanol-induced locomotor activity in DBA/2J mice. | Sprow GM et al. | β | 2014 | β |
| Influence of adolescent heavy session drinking on the systemic and brain innate immune system. | Ward RJ et al. | β | 2014 | β |
| Neuroimmune activation and myelin changes in adolescent rats exposed to high-dose alcohol and associated cognitive dysfunction: a review with reference to human adolescent drinking. | Pascual M et al. | β | 2014 | β |
| Reinforcing properties and neurochemical response of ethanol within the posterior ventral tegmental area are enhanced in adulthood by periadolescent ethanol consumption. | Toalston JE et al. | β | 2014 | β |
| Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats. | Acevedo MB et al. | β | 2014 | β |
| Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages. | Yang JY et al. | β | 2014 | β |
| Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis. | Burke AR et al. | β | 2014 | β |
| The Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences. | Cozzoli DK et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| Adolescent alcohol exposure alters the rat adult hypothalamic-pituitary-adrenal axis responsiveness in a sex-specific manner. | Logrip ML et al. | β | 2013 | β |
| Adolescent binge-like ethanol exposure reduces basal Ξ±-MSH expression in the hypothalamus and the amygdala of adult rats. | Lerma-Cabrera JM et al. | β | 2013 | β |
| Alcohol and NMDA receptor: current research and future direction. | Chandrasekar R | β | 2013 | β |
| Alcohol exposure during development: Impact on the epigenome. | Perkins A et al. | β | 2013 | β |
| Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasteride. | Milivojevic V et al. | β | 2013 | β |
| Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. | Legastelois R et al. | β | 2013 | β |
| Brain structural and functional changes in adolescents with psychiatric disorders. | Miguel-Hidalgo JJ | β | 2013 | β |
| Changes in CREB activation in the prefrontal cortex and hippocampus blunt ethanol-induced behavioral sensitization in adolescent mice. | Soares-Simi SL et al. | β | 2013 | β |
| Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus. | Kurosawa R et al. | β | 2013 | β |
| Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats. | Sari Y et al. | β | 2013 | β |
| Effects of intermittent binge alcohol exposure on long-term motor function in young rats. | Forbes A et al. | β | 2013 | β |
| Effects of voluntary access to sweetened ethanol during adolescence on intake in adulthood. | Broadwater M et al. | β | 2013 | β |
| Epigenetic control of gene expression in the alcoholic brain. | Ponomarev I | β | 2013 | β |
| Epigenetics and early life origins of chronic noncommunicable diseases. | Wang G et al. | β | 2013 | β |
| Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain. | Barker JM et al. | β | 2013 | β |
| Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. | Chorlian DB et al. | β | 2013 | β |
| Impact of pubertal stage at first drink on adult drinking behavior. | Blomeyer D et al. | β | 2013 | β |
| Juvenile ethanol exposure increases rewarding properties of cocaine and morphine in adult DBA/2J mice. | Molet J et al. | β | 2013 | β |
| Neurotoxic effects of alcohol in adolescence. | Jacobus J et al. | β | 2013 | β |
| Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal. | Carrara-Nascimento PF et al. | β | 2013 | β |
| The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. | Gulley JM et al. | β | 2013 | β |
| The role of the aversive effects of drugs in self-administration: assessing the balance of reward and aversion in drug-taking behavior. | Verendeev A et al. | β | 2013 | β |
| Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges. | Semenova S | β | 2012 | β |
| Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning. | Pascual M et al. | β | 2012 | β |
| Chronic ethanol exposure during adolescence alters the behavioral responsiveness to ethanol in adult mice. | Quoilin C et al. | β | 2012 | β |
| Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. | Duncan JR | β | 2012 | β |
| Dopamine D2 receptor gene polymorphisms in newborn infants of drug-using women. | Oei JL et al. | β | 2012 | β |
| Effects of ethanol during adolescence on the number of neurons and glia in the medial prefrontal cortex and basolateral amygdala of adult male and female rats. | Koss WA et al. | β | 2012 | β |
| Epigenetic mechanisms and therapeutic perspectives for neurodevelopmental disorders. | Kubota T et al. | β | 2012 | β |
| Epigenetics in autism and other neurodevelopmental diseases. | Miyake K et al. | β | 2012 | β |
| Ethanol exposure during either adolescence or adulthood alters the rewarding effects of cocaine in adult rats. | Hutchison MA et al. | β | 2012 | β |
| Executive functioning and alcohol binge drinking in university students. | Parada M et al. | β | 2012 | β |
| Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice. | Botia B et al. | β | 2012 | β |
| Genetic and environmental determinants of stress responding. | Clarke TK et al. | β | 2012 | β |
| Histone acetylation of the htr3a gene in the prefrontal cortex of Wistar rats regulates ethanol-seeking behavior. | Xu Y et al. | β | 2012 | β |
| Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. | Sakharkar AJ et al. | β | 2012 | β |
| Increased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL/6J mice. | Spanos M et al. | β | 2012 | β |
| Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. | Feduccia AA et al. | β | 2012 | β |
| Addiction, adolescence, and innate immune gene induction. | Crews FT et al. | β | 2011 | β |
| Adolescent binge alcohol exposure induces long-lasting partial activation of microglia. | McClain JA et al. | β | 2011 | β |
| Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. | Coleman LG et al. | β | 2011 | β |
| Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performance. | Thoma RJ et al. | β | 2011 | β |
| Age at menarche is associated with divergent alcohol use patterns in early adolescence and early adulthood. | Richards MA et al. | β | 2011 | β |
| Associations between heavy drinking and changes in impulsive behavior among adolescent boys. | White HR et al. | β | 2011 | β |
| Behavioral epigenetics. | Lester BM et al. | β | 2011 | β |
| Binge drinking +/- chronic nicotine administration alters extracellular glutamate and arginine levels in the nucleus accumbens of adult male and female Wistar rats. | Lallemand F et al. | β | 2011 | β |
| Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity. | Przybycien-Szymanska MM et al. | β | 2011 | β |
| Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. | Broadwater M et al. | β | 2011 | β |
| Enhancement of histone acetylation in midbrain of mice with ethanol physical dependence and its withdrawal. | Shibasaki M et al. | β | 2011 | β |
| Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. | Dudley KJ et al. | β | 2011 | β |
| Epigenetic regulation of gene expression in physiological and pathological brain processes. | GrΓ€ff J et al. | β | 2011 | β |
| Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. | Allen CD et al. | β | 2011 | β |
| Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage. | Pascual M et al. | β | 2011 | β |
| L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKCΞ³ phosphorylation in mice with methamphetamine-induced place preference. | Shibasaki M et al. | β | 2011 | β |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | β | 2011 | β |
| Opposite effects of acute ethanol exposure on GAP-43 and BDNF expression in the hippocampus versus the cerebellum of juvenile rats. | Kulkarny VV et al. | β | 2011 | β |
| Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-Ξ³ agonists. | Kane CJ et al. | β | 2011 | β |
| Sex differences in the effects of ethanol pre-exposure during adolescence on ethanol-induced conditioned taste aversion in adult rats. | Sherrill LK et al. | β | 2011 | β |
| The effects of pre-pubertal gonadectomy and binge-like ethanol exposure during adolescence on ethanol drinking in adult male and female rats. | Sherrill LK et al. | β | 2011 | β |
| Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience. | Nixon K et al. | β | 2010 | β |
| Alcohol and the prefrontal cortex. | Abernathy K et al. | β | 2010 | β |
| Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. | Relton CL et al. | β | 2010 | β |
| Genetic and environmental influences on ethanol consumption: perspectives from preclinical research. | Pautassi RM et al. | β | 2010 | β |
| High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence. | Acevedo MB et al. | β | 2010 | β |
| How the epigenome contributes to the development of psychiatric disorders. | Bredy TW et al. | β | 2010 | β |
| Induction of epigenetic alterations by dietary and other environmental factors. | Mathers JC et al. | β | 2010 | β |
| Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. | Guerri C et al. | β | 2010 | β |
| Neuroscience of alcoholism: molecular and cellular mechanisms. | Moonat S et al. | β | 2010 | β |
| Nicotine: alcohol reward interactions. | Lajtha A et al. | β | 2010 | β |
| N-methyl-D-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure. | Pian JP et al. | β | 2010 | β |
| Novel etiological and therapeutic strategies for neurodiseases: epigenetic understanding of gene-environment interactions. | Kubota T et al. | β | 2010 | β |
| Reduced alcohol drinking in adult rats exposed to sucrose during adolescence. | Vendruscolo LF et al. | β | 2010 | β |
| Research on alcohol and adolescent brain development: opportunities and future directions. | Witt ED | β | 2010 | β |
| Role of central nervous system insulin resistance in fetal alcohol spectrum disorders. | de la Monte SM et al. | β | 2010 | β |
| Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. | Malvaez M et al. | β | 2009 | β |
| Increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice. | Oliveira-da-Silva A et al. | β | 2009 | β |
| Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi. | Philpot RM et al. | β | 2009 | β |