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Chunk #15 — 2. Methods — 2.5. Participants

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Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300.
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The minor offspring of HR proband pairs and their adult siblings along with control offspring are currently being followed in longitudinal initiatives and are the subject of this report. Three generation pedigree information for the HR offspring reveals an average of 4 first and second-degree relatives with alcohol dependence.