A large scale follow-up using repeated ERP assessments of child and adolescent offspring from alcohol dependent and control families revealed that trajectories of visual P300 for the offspring, most of whom were tested four or more times, differed by familial risk group (Hill et al., 1999; Hill and Shen, 2002). These studies suggested that while amplitude of P300 at one point in time may reveal risk for later development of substance use disorders, age-related change in P300 amplitude may provide a more salient biological marker of AD risk in youth than single point measures.
