N400 and semantic categorization in schizophrenia.
paper
Cited
Public
Unavailable
- Authors
- Grillon, C; Ameli, R; Glazer, W M
- Year
- 1991
- Journal
- Biological psychiatry
- PMID
- 2018820
- DOI
- 10.1016/0006-3223(91)90269-r
The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contained a negative component, N400, which was reduced and delayed in the patients. However, inspection of individual subjects' data indicated that N400 was abnormal only in a subgroup of schizophrenics. Abnormalities in the amplitude of N400 suggest impairments in semantic expectancies, whereas abnormalities in the latency of N400 suggest a delay in information processing.
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