A simple auditory oddball task in young adult males at high risk for alcoholism.
paper
Cited
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- Authors
- Ramachandran, G; Porjesz, B; Begleiter, H; Litke, A
- Year
- 1996
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 8651469
- DOI
- 10.1111/j.1530-0277.1996.tb01035.x
The reduction in the amplitude of the auditory P300 in young adult males at high risk for alcoholism has not been as consistently replicated as has been the reduction in the visual P300 amplitude in the same group. The easier nature of the auditory task was thought to be responsible for the inconsistency. We examined the auditory P300 amplitude in a group that has not yet been studied, young adult sons of alcoholics (mean age = 24.9 years, n = 48), and compared them with age and sex-matched controls (mean age = 27.8 years, n = 23). We found the auditory P300 amplitude to be reduced in the high-risk group and this reduction to be the greatest over the posterior centroparietal and occipital areas when individual leads were examined. We further analyzed the data using current source density, a mathematical transformation that circumvents some of the errors inherent in measuring scalp-evoked potentials, and found reduced current source density in the high-risk group in the posterior central and parietal areas. Thus, we found that a simple auditory oddball task was effective in eliciting P300 differences in groups at high and low risk for alcoholism. The clinical significance of the P300 is discussed, as well as the relevance of task difficulty in eliciting auditory P300 differences in young males at high risk for alcoholism.
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| The P300 in alcohol use disorder: A meta-analysis and meta-regression. | Hamidovic A et al. | — | 2019 | → |
| Differential impairments across attentional networks in binge drinking. | Lannoy S et al. | — | 2017 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. | Kamarajan C et al. | — | 2015 | → |
| Objective measurement of visual resolution using the P300 to self-facial images. | Marhöfer DJ et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. | Kamarajan C et al. | — | 2015 | → |
| Attentional alterations in alcohol dependence are underpinned by specific executive control deficits. | Maurage P et al. | — | 2014 | → |
| Faces are more attractive than motion: evidence from two simultaneous oddball paradigms. | Marhöfer DJ et al. | — | 2014 | → |
| Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism. | Narayanan B et al. | — | 2013 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| The P300 event-related potential and smoking--a population-based case-control study. | Mobascher A et al. | — | 2010 | → |
| Auditory P300 event-related potentials and neurocognitive functions in opioid dependent men and their brothers. | Singh SM et al. | — | 2009 | → |
| Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: association with PTSD. | Metzger LJ et al. | — | 2009 | → |
| Global-local interference is related to callosal compromise in alcoholism: a behavior-DTI association study. | Müller-Oehring EM et al. | — | 2009 | → |
| Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. | Roopesh BN et al. | — | 2009 | → |
| The P300 event-related potential and its possible role as an endophenotype for studying substance use disorders: a review. | Singh SM et al. | — | 2009 | → |
| Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. | Rangaswamy M et al. | — | 2007 | → |
| Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. | Padmanabhapillai A et al. | — | 2006 | → |
| S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism. | Jones KA et al. | — | 2006 | → |
| Direct and mediated associations between P300 amplitude in childhood and substance use disorders outcome in young adulthood. | Habeych ME et al. | — | 2005 | → |
| Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Alcoholism risk, tobacco smoking, and P300 event-related potential. | Polich J et al. | — | 2004 | → |
| Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability. | Palomo T et al. | — | 2004 | → |
| Alcoholism risk and the P300 event-related brain potential: modality, task, and gender effects. | Reese C et al. | — | 2003 | → |
| Auditory P3 in female alcoholics. | Suresh S et al. | — | 2003 | → |
| Depression and familial risk for substance dependence: a P300 study of young women. | Houston RJ et al. | — | 2003 | → |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | — | 2003 | → |
| Alcohol use disorders and anxiety disorders: relation to the P300 event-related potential. | Enoch MA et al. | — | 2001 | → |
| Auditory P3a deficits in male subjects at high risk for alcoholism. | Hada M et al. | — | 2001 | → |
| Mismatch negativity in subjects at high risk for alcoholism. | Zhang XL et al. | — | 2001 | → |
| N1 and P300 abnormalities in patients with schizophrenia, epilepsy, and epilepsy with schizophrenialike features. | Ford JM et al. | — | 2001 | → |
| Visual P3 findings in Mission Indian youth: relationship to family history of alcohol dependence and behavioral problems. | Ehlers CL et al. | — | 2001 | → |
| Similarities in the disturbances in cortical information processing in alcoholism and aging: a pilot evoked potential study. | Boutros NN et al. | — | 2000 | → |
| The effect of motivational instructions on P300 amplitude. | Carrillo-de-la-Peña MT et al. | — | 2000 | → |
| Absence of visual and auditory P300 reduction in nondepressed male and female alcoholics. | Hill SY et al. | — | 1999 | → |
| P300, alcoholism heritability, and stimulus modality. | Polich J et al. | — | 1999 | → |
| P300: the similarities and differences in the scalp distribution of visual and auditory modality. | Ji J et al. | — | 1999 | → |
| Visual P3a in male subjects at high risk for alcoholism. | Rodríguez Holguín S et al. | — | 1999 | → |
| What is inherited in the predisposition toward alcoholism? A proposed model. | Begleiter H et al. | — | 1999 | → |
| Event-related potentials during visual selective attention in children of alcoholics. | van der Stelt O et al. | — | 1998 | → |
| Genetic basis of event-related potentials and their relationship to alcoholism and alcohol use. | Porjesz B et al. | — | 1998 | → |
| Mismatch negativity in young children of alcoholics from high-density families. | Rodríguez Holguín S et al. | — | 1998 | → |
| P3 scalp topography to target and novel visual stimuli in children of alcoholics. | Van der Stelt O et al. | — | 1998 | → |
| Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. | Begleiter H et al. | — | 1998 | → |
| Visual and auditory event-related potentials in young children of alcoholics from high- and low-density families. | Rodríguez Holguín S et al. | — | 1998 | → |
| Neuroelectric correlates of response production and inhibition in individuals at risk to develop alcoholism. | Cohen HL et al. | — | 1997 | → |
| Neurophysiological correlates of response production and inhibition in alcoholics. | Cohen HL et al. | — | 1997 | → |
| Direct effects of ethanol on signaling proteins. | Charness ME | — | 1996 | → |