Clinical characteristics of familial versus sporadic alcoholism in a sample of male and female patients.
- Authors
- Limosin, F; Gorwood, P; Adès, J
- Year
- 2001
- Journal
- European psychiatry : the journal of the Association of European Psychiatrists
- PMID
- 11353592
- DOI
- 10.1016/s0924-9338(01)00556-9
Presence of a family history of alcoholism may predict clinical characteristics in affected subjects, such as an earlier age at onset. More frequent and severe social maladjustment and somatic complications are also regularly cited for familial alcoholism, although subject to many other confusing factors. We analysed the clinical specificities of 79 alcohol-dependent inpatients according to the absence versus presence of family history of alcoholism. Patients were evaluated for lifetime psychiatric morbidity with the Diagnostic Interview for Genetic Studies (DIGS), for somatic complications with a systematic screening list, and first-degree relatives (N = 428) were assessed with the Family Inventory Schedule and Criteria (FISC). Age at onset and social complications were predicting familial versus sporadic alcoholism, even when considering censored data and/or interaction between variables. But differences became non-significant when excluding patients with antisocial personality. If age at onset effectively appears to be the most informative characteristic for predicting familial versus sporadic alcoholism, it seems that it may be necessary in future studies to systematically take into account antisocial personality diagnosis, because of a probable contamination.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cognitive mediators and disparities in the relation between teen depressiveness and smoking. | Mistry R et al. | — | 2014 | → |
| Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. | Kapoor M et al. | — | 2014 | → |
| Clinical indices of familial alcohol use disorder. | Kendler KS et al. | — | 2012 | → |
| A new definition of early age at onset in alcohol dependence. | Le Strat Y et al. | — | 2010 | → |
| Medication overuse headache: biobehavioral issues and solutions. | Lake AE | — | 2006 | → |