Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior.
- Authors
- Legrand, L N; Keyes, M; McGue, M; Iacono, W G; Krueger, R F
- Year
- 2008
- Journal
- Psychological medicine
- PMID
- 17903338
- DOI
- 10.1017/S0033291707001596
- PMCID
- PMC4498796
BACKGROUND: There is increasing evidence that certain environmental factors can modify genetic effects. This is an important area of investigation as such work will help to guide the development of new intervention programs. In this paper, we address whether rural environments moderate the genetic influence on adolescent substance use and rule-breaking behavior (i.e. externalizing psychopathology). METHOD: Over 1200 Minnesotan 17-year-old twins were classified as either urban or rural. Externalizing behavior was operationalized as the use and abuse of alcohol and drugs along with symptoms of conduct, oppositional defiant, and antisocial personality disorders. Biometric factor modeling estimated whether the relative contribution of genetic and shared environmental factors varied from urban to rural settings. RESULTS: Residency effects reached statistical significance in the male sample only. In urban environments, externalizing behavior was substantially influenced by genetic factors, but in rural environments, shared environmental factors became more influential. This was apparent at both the individual-variable and factor levels. CONCLUSIONS: These findings suggest a gene-environment interaction in the development of male adolescents' problem behaviors, including substance use. The results fit within an expanding literature demonstrating both the contextual nature of the heritability statistic and how certain environments may constrain the expression of genetic tendencies.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort. | Teeuw J et al. | — | 2023 | → |
| Exploring Rural-Urban Differences in Polygenic Associations for Health among Older Adults in the United States. | Davidson T et al. | — | 2022 | → |
| Network Analysis of Time Use and Depressive Symptoms Among Emerging Adults: Findings From the Guizhou Population Health Cohort Study. | Ma Z et al. | — | 2022 | → |
| Adolescent Externalizing Psychopathology and Its Prospective Relationship to Marijuana Use Development from Age 14 to 30: Replication Across Independent Longitudinal Twin Samples. | Zellers SM et al. | — | 2020 | → |
| Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients. | Williams PT | — | 2020 | → |
| Substance use: Interplay between polygenic risk and neighborhood environment. | Pasman JA et al. | — | 2020 | → |
| Family Aggregation of Substance Use Disorders: Substance Specific, Nonspecific, and Intrafamilial Sources of Risk. | Farmer RF et al. | — | 2019 | → |
| Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample. | Sartor CE et al. | — | 2018 | → |
| Genetic influences on conduct disorder. | Salvatore JE et al. | — | 2018 | → |
| Socioeconomic Status and Adolescent Alcohol Involvement: Evidence for a Gene-Environment Interaction. | Davis CN et al. | — | 2018 | → |
| Genetic and environmental origins of gambling behaviors from ages 18 to 25: A longitudinal twin family study. | King SM et al. | — | 2017 | → |
| Moderation of Genetic Influences on Alcohol Involvement by Rural Residency among Adolescents: Results from the 1962 National Merit Twin Study. | Davis CN et al. | — | 2017 | → |
| Antisocial peer affiliation and externalizing disorders in the transition from adolescence to young adulthood: Selection versus socialization effects. | Samek DR et al. | — | 2016 | → |
| Beyond comorbidity: Toward a dimensional and hierarchical approach to understanding psychopathology across the life span. | Forbes MK et al. | — | 2016 | → |
| Gene-environment interplay between parent-child relationship problems and externalizing disorders in adolescence and young adulthood. | Samek DR et al. | — | 2015 | → |
| Socioeconomic status moderates genetic and environmental effects on the amount of alcohol use. | Hamdi NR et al. | — | 2015 | → |
| Understanding Addiction as a Developmental Disorder: An Argument for a Developmentally Informed Multilevel Approach. | McCrory EJ et al. | — | 2015 | → |
| Delineating selection and mediation effects among childhood personality and environmental risk factors in the development of adolescent substance abuse. | Hicks BM et al. | — | 2014 | → |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | — | 2014 | → |
| New diagnostic criteria for alcohol use disorders and novel treatment approaches - 2014 update. | Tyburski EM et al. | — | 2014 | → |
| Parent-child conflict as an etiological moderator of childhood conduct problems: an example of a 'bioecological' gene-environment interaction. | Burt SA et al. | — | 2014 | → |
| Alcohol consumption in men is influenced by qualitatively different genetic factors in adolescence and adulthood. | Edwards AC et al. | — | 2013 | → |
| Common genetic and nonshared environmental factors contribute to the association between socioemotional dispositions and the externalizing factor in children. | Taylor J et al. | — | 2013 | → |
| Disentangling the relative contribution of parental antisociality and family discord to child disruptive disorders. | Bornovalova MA et al. | — | 2013 | → |
| Genetic amplification and the individualization of the parent-child relationship across adolescence. | Ludeke S et al. | — | 2013 | → |
| Genotype by environment interaction and neurodevelopment III. Focus on the child's broader social ecology. | Bellani M et al. | — | 2013 | → |
| How genes and the social environment moderate each other. | Reiss D et al. | — | 2013 | → |
| Overview of Behavioral Genetics Research for Family Researchers. | Samek D et al. | — | 2013 | → |
| The genetics of alcohol dependence. | Rietschel M et al. | — | 2013 | → |
| The Texas Twin Project. | Harden KP et al. | — | 2013 | → |
| Trends in adolescent alcohol use: effects of age, sex and cohort on prevalence and heritability. | Geels LM et al. | — | 2012 | → |
| Agency versus structure: genetics, group membership, and a new twist on an old debate. | Angel RJ | — | 2011 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |
| Heritability of smoking, alcohol use, and psychological characteristics among adolescent twins in Qingdao, China. | Unger JB et al. | — | 2011 | → |
| Migration from Mexico to the United States and conduct disorder: a cross-national study. | Breslau J et al. | — | 2011 | → |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | — | 2011 | → |
| Commentary on Agrawal et al. (2010): Social environments modulate alcohol use. | Rose RJ et al. | — | 2010 | → |
| Genetic and environmental influences on psychiatric comorbidity: a systematic review. | Cerdá M et al. | — | 2010 | → |
| The end of behavioral genetics? 2008. | McGue M | — | 2010 | → |
| Externalizing disorders: cluster 5 of the proposed meta-structure for DSM-V and ICD-11. | Krueger RF et al. | — | 2009 | → |
| Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. | Dick DM et al. | — | 2009 | → |
| The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. | Dick DM et al. | — | 2009 | → |
| Genetic and environmental contributions to the diversity of substances used in adolescent twins: a longitudinal study of age and sex effects. | Derringer J et al. | — | 2008 | → |
| Temperament influences on parenting and child psychopathology: socio-economic disadvantage as moderator. | Flouri E | — | 2008 | → |
| The End of Behavioral Genetics? | McGue M | — | 2008 | → |