Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction.
paper
Primary
Public
Unavailable
- Authors
- Dick, Danielle M; Agrawal, Arpana; Schuckit, Marc A; Bierut, Laura; Hinrichs, Anthony; Fox, Louis; Mullaney, Joseph; Cloninger, C Robert; Hesselbrock, Victor; Nurnberger, John I; Almasy, Laura; Foroud, Tatiana; Porjesz, Bernice; Edenberg, Howard; Begleiter, Henri
- Year
- 2006
- Journal
- Journal of studies on alcohol
- PMID
- 16562401
- DOI
- 10.15288/jsa.2006.67.185
OBJECTIVE: The gene GABRA2 has been associated with the risk for alcohol dependence in independent samples. This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence. METHOD: Data from more than 1,900 male and female subjects from the Collaborative Study of the Genetics of Alcoholism (COGA) sample were analyzed. Subjects were recruited based on membership in a family with multiple individuals with alcoholism. A series of analyses was performed to evaluate the relationship between the following: (1) GABRA2 and alcohol dependence, (2) marital status and alcohol dependence, (3) GABRA2 and marital status, and (4) interactions between GABRA2 and marital status on the development of alcohol dependence in the high-risk COGA sample. Additional analyses were carried out in a sample of approximately 900 individuals from control families to test the generalizability of results. RESULTS: Both GABRA2 and marital status contributed independently to the development of alcohol dependence in the COGA sample. The high-risk genotype at GABRA2 was also related to a decreased likelihood of marrying and an increased likelihood of divorce, which appeared to be mediated in part by personality characteristics. There was also differential risk associated with the GABRA2 genotype according to marital status. CONCLUSIONS: These analyses provide evidence of both gene-environment correlation and gene-environment interaction associated with GABRA2, marital status, and alcohol dependence. They illustrate the complex pathways by which genotype and environmental risk factors act and interact to influence alcohol dependence and challenge traditional conceptualizations of "environmental" risk factors.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Candidate gene-environment interactions in substance abuse: A systematic review. | Jiang Z et al. | β | 2023 | β |
| Does application of complexity theory simplify concepts of psychiatry: Analogies and insights. | Prakash J et al. | β | 2021 | β |
| Alcohol Use Disorder and Parental Alcohol Use Disorder as Predictors of Reproductive Timing. | Blake A et al. | β | 2020 | β |
| Prevalence of Alcohol Use Disorders and Their Association with Sociodemographic Determinants and Depression/Anxiety Disorders in a Representative Sample of the Greek General Population. | Bellos S et al. | β | 2020 | β |
| Sex differences in the relative influence of marital status and parenthood on alcohol use disorder symptoms: A multilevel discordant twin design. | Dash GF et al. | β | 2020 | β |
| Romantic Partner Alcohol Misuse Interacts with <i>GABRA2</i> Genotype to Predict Frequency of Drunkenness in Young Adulthood. | Gajos JM et al. | β | 2019 | β |
| A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults. | Kim J et al. | β | 2018 | β |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | β | 2018 | β |
| A GABRA2 polymorphism improves a model for prediction of drinking initiation. | Kuperman S et al. | β | 2017 | β |
| GABA<sub>A</sub> receptor subtype involvement in addictive behaviour. | Stephens DN et al. | β | 2017 | β |
| Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations. | Chartier KG et al. | β | 2017 | β |
| Genetic and Neuroimaging Features of Personality Disorders: State of the Art. | Ma G et al. | β | 2016 | β |
| Genetic influences on adolescent behavior. | Dick DM et al. | β | 2016 | β |
| Mechanisms in the relation between GABRA2 and adolescent externalizing problems. | Wang FL et al. | β | 2016 | β |
| Child-evoked maternal negativity from 9 to 27 months: Evidence of gene-environment correlation and its moderation by marital distress. | Fearon RM et al. | β | 2015 | β |
| Inferring Selective Constraint from Population Genomic Data Suggests Recent Regulatory Turnover in the Human Brain. | Schrider DR et al. | β | 2015 | β |
| Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. | Salvatore JE et al. | β | 2015 | β |
| Academic achievement as a moderator of genetic influences on alcohol use in adolescence. | Benner AD et al. | β | 2014 | β |
| Concordant and discordant alcohol, tobacco, and marijuana use as predictors of marital dissolution. | Leonard KE et al. | β | 2014 | β |
| Gene Γ environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution. | Keller MC | β | 2014 | β |
| Genetic and environmental continuity in personality development: a meta-analysis. | Briley DA et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents. | Villafuerte S et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Romantic relationship status and alcohol use and problems across the first year of college. | Salvatore JE et al. | β | 2014 | β |
| Child dopamine active transporter 1 genotype and parenting: evidence for evocative gene-environment correlations. | Hayden EP et al. | β | 2013 | β |
| Defining the environment in gene-environment research: lessons from social epidemiology. | Boardman JD et al. | β | 2013 | β |
| Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. | Perry BL et al. | β | 2013 | β |
| Gene-environment correlation: difficulties and a natural experiment-based strategy. | Wagner B et al. | β | 2013 | β |
| Gene Γ environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children. | Lavigne JV et al. | β | 2013 | β |
| Genes of experience: explaining the heritability of putative environmental variables through their association with behavioural and emotional traits. | McAdams TA et al. | β | 2013 | β |
| Genetics and epigenetics of alcohol dependence. | Nieratschker V et al. | β | 2013 | β |
| How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity. | Dick DM et al. | β | 2013 | β |
| Stressful Life Events and Relapse Among Formerly Alcohol Dependent Adults. | Pilowsky DJ et al. | β | 2013 | β |
| Deconstructing the age-prevalence curve of alcohol dependence: why "maturing out" is only a small piece of the puzzle. | VergΓ©s A et al. | β | 2012 | β |
| Gene Γ environment vulnerability factors for PTSD: the HPA-axis. | Mehta D et al. | β | 2012 | β |
| Genetics of GABAergic signaling in nicotine and alcohol dependence. | Cui WY et al. | β | 2012 | β |
| Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. | Villafuerte S et al. | β | 2012 | β |
| Levels of explanation in psychiatric and substance use disorders: implications for the development of an etiologically based nosology. | Kendler KS | β | 2012 | β |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | β | 2012 | β |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | β | 2012 | β |
| Ξ±2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. | Engin E et al. | β | 2012 | β |
| Adult-born neuron development is controlled by GABAA receptor subtypes (Commentary on Duveau et al.). | Bordey A | β | 2011 | β |
| Psychosocial correlates of alcohol use and reduction for individuals with hepatitis C. | Perzynski AT et al. | β | 2011 | β |
| The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. | Young-Wolff KC et al. | β | 2011 | β |
| Biosocial Influences on the Family: A Decade Review. | D'Onofrio BM et al. | β | 2010 | β |
| The genetic epidemiology of personality disorders. | Reichborn-Kjennerud T | β | 2010 | β |
| ALDH2, ADH1B and alcohol expectancies: integrating genetic and learning perspectives. | Hendershot CS et al. | β | 2009 | β |
| Associations among GABRG1, level of response to alcohol, and drinking behaviors. | Ray LA et al. | β | 2009 | β |
| Gene-environment interactions and alcohol use and dependence: current status and future challenges. | van der Zwaluw CS et al. | β | 2009 | β |
| Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism. | Laucht M et al. | β | 2009 | β |
| Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability. | Button TM et al. | β | 2009 | β |
| Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. | Dick DM et al. | β | 2009 | β |
| The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans. | Du Y et al. | β | 2009 | β |
| Typologies of alcohol dependence. From Jellinek to genetics and beyond. | Leggio L et al. | β | 2009 | β |
| Addiction science and its genetics. | Ball D | β | 2008 | β |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | β | 2008 | β |
| Desistance from delinquency: the marriage effect revisited and extended. | Beaver KM et al. | β | 2008 | β |
| Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study. | Lind PA et al. | β | 2008 | β |
| Explanatory models for psychiatric illness. | Kendler KS | β | 2008 | β |
| Externalizing disorders in the offspring from the San Diego prospective study of alcoholism. | Schuckit MA et al. | β | 2008 | β |
| Genetic and early environmental contributions to alcohol's aversive and physiological effects. | Roma PG et al. | β | 2008 | β |
| Genetics of personality disorders. | Reichborn-Kjennerud T | β | 2008 | β |
| Genotype-environment correlations: implications for determining the relationship between environmental exposures and psychiatric illness. | Jaffee SR et al. | β | 2008 | β |
| Multiple-domain predictors of problematic alcohol use in young adulthood. | Kramer JR et al. | β | 2008 | β |
| The nature of nurture: a genomewide association scan for family chaos. | Butcher LM et al. | β | 2008 | β |
| Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. | Rangaswamy M et al. | β | 2008 | β |
| Under the influence of genetics: how transdisciplinarity leads us to rethink social pathways to illness. | Pescosolido BA et al. | β | 2008 | β |
| Evidence of a gene x environment interaction in the creation of victimization: results from a longitudinal sample of adolescents. | Beaver KM et al. | β | 2007 | β |
| Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. | Jaffee SR et al. | β | 2007 | β |
| Genetic expression outside the skin: clues to mechanisms of Genotype x Environment interaction. | Reiss D et al. | β | 2007 | β |
| Genomewide suggestive linkage of opioid dependence to chromosome 14q. | Lachman HM et al. | β | 2007 | β |
| The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. | Matthews AG et al. | β | 2007 | β |
| The genetics of alcohol dependence. | Dick DM et al. | β | 2006 | β |
| The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. | Dick DM et al. | β | 2006 | β |
| The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. | Dick DM et al. | β | 2006 | β |
| No association between dopamine D4 receptor gene variants and novelty seeking. | JΓΆnsson EG et al. | β | 2002 | β |