Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics.
paper
Cited
Public
Unavailable
- Authors
- Pollock, V E
- Year
- 1992
- Journal
- The American journal of psychiatry
- PMID
- 1415821
- DOI
- 10.1176/ajp.149.11.1534
OBJECTIVE: Meta-analysis was used to review the research literature on self-reported sensitivity to alcohol among sons of alcoholic and among normal control subjects. METHOD: Computerized and manual searches identified 17 eligible independent articles; nine contained the information necessary to compute effect sizes, and additional data on two other studies were provided by authors in response to written and telephone requests. RESULTS: Findings from 10 studies indicated that sons of alcoholics report significantly less sensitivity to alcohol than normal control subjects overall and during the ascending (i.e., 0-35 minutes after alcohol) and descending (i.e., 40-240 minutes after alcohol) limbs of the blood alcohol curve. Response to placebo did not significantly distinguish these groups in the five studies that included such assessment. CONCLUSIONS: It may be appropriate to appraise the biological sons of male alcoholics that they may experience less subjective sensitivity to alcohol than other individuals, but it is not possible to predict whether any particular individual will experience such lower sensitivity. In addition, self-report data can be influenced by many factors, and further research that assesses multiple psychological and physiological measures and uses longitudinal designs is needed to determine the relationship between specific factors and the development of alcoholism.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Precision medicine in substance use disorders: Integrating behavioral, environmental, and biological insights. | Guerrin CGJ et al. | — | 2025 | → |
| Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment. | Karatayev O et al. | — | 2024 | → |
| Subjective intoxication predicts alcohol-related consequences at equivalent alcohol concentrations in young adults using ecological momentary assessment and alcohol sensors. | Richards VL et al. | — | 2024 | → |
| Paternal alcohol exposure attenuates maintenance and reinstated operant responding for alcohol in the offspring of rats. | Nieto SJ et al. | — | 2023 | → |
| Paternal alcohol exposure reduces acquisition of operant alcohol self-administration and affects Bdnf DNA methylation in male and female offspring. | Nieto SJ et al. | — | 2022 | → |
| Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses. | Martins JS et al. | — | 2019 | → |
| Women's Alcohol Sensitivity Predicts Alcohol-Related Regretted Sex. | Hone LSE et al. | — | 2017 | → |
| The Alcohol Sensitivity Questionnaire: Evidence for Construct Validity. | Fleming KA et al. | — | 2016 | → |
| Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. | Finegersh A et al. | — | 2015 | → |
| Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. | Enoch MA | — | 2014 | → |
| Initial responses to the first dose of nicotine in novel smokers: the role of exposure to environmental smoking and genetic predisposition. | Schuck K et al. | — | 2014 | → |
| Relationships between impulsivity and subjective response in an IV ethanol paradigm. | Leeman RF et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | — | 2013 | → |
| Influence of alcohol use and family history of alcoholism on neural response to alcohol cues in college drinkers. | Dager AD et al. | — | 2013 | → |
| Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation. | Oliver JA et al. | — | 2013 | → |
| Alcohol increases impulsivity and abuse liability in heavy drinking women. | Reed SC et al. | — | 2012 | → |
| The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats. | Besheer J et al. | — | 2012 | → |
| Glypican Gene GPC5 Participates in the Behavioral Response to Ethanol: Evidence from Humans, Mice, and Fruit Flies. | Joslyn G et al. | — | 2011 | → |
| Predictors and outcomes of variability in subjective alcohol intoxication among college students: an event-level analysis across 4 years. | Quinn PD et al. | — | 2011 | → |
| Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. | Evans SM et al. | — | 2011 | → |
| Role of GABRA2 in moderating subjective responses to alcohol. | Roh S et al. | — | 2011 | → |
| Subjective responses to alcohol: a paradigm shift may be brewing. | King AC et al. | — | 2011 | → |
| Subjective response to alcohol challenge: a quantitative review. | Quinn PD et al. | — | 2011 | → |
| The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. | Webb A et al. | — | 2011 | → |
| Alcohol impairment of saccadic and smooth pursuit eye movements: impact of risk factors for alcohol dependence. | Roche DJ et al. | — | 2010 | → |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | — | 2010 | → |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | — | 2010 | → |
| Human variation in alcohol response is influenced by variation in neuronal signaling genes. | Joslyn G et al. | — | 2010 | → |
| Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. | Ray LA et al. | — | 2010 | → |
| Subjective response to alcohol: a critical review of the literature. | Morean ME et al. | — | 2010 | → |
| Gender differences in factors influencing alcohol use and drinking progression among adolescents. | Schulte MT et al. | — | 2009 | → |
| Subjective stimulant and sedative effects of alcohol during early drinking experiences predict alcohol involvement in treated adolescents. | Chung T et al. | — | 2009 | → |
| Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking. | Perkins KA et al. | — | 2009 | → |
| Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. | Ehlers CL et al. | — | 2008 | → |
| Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. | D'Souza DC et al. | — | 2008 | → |
| Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. | Joslyn G et al. | — | 2008 | → |
| Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study. | Lind PA et al. | — | 2008 | → |
| Ethanol and pain sensitivity: effects in healthy subjects using an acute pain paradigm. | Perrino AC et al. | — | 2008 | → |
| Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. | Chappell AM et al. | — | 2008 | → |
| The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects. | Schuckit MA et al. | — | 2008 | → |
| Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population. | Zhang D et al. | — | 2007 | → |
| A rational approach to the pharmacotherapy of alcohol dependence. | Petrakis IL | — | 2006 | → |
| Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior. | Corbin WR et al. | — | 2006 | → |
| The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. | Krystal JH et al. | — | 2006 | → |
| A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. | Schuckit MA et al. | — | 2005 | → |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | — | 2005 | → |
| An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. | Hu X et al. | — | 2005 | → |
| Autosomal linkage analysis for the level of response to alcohol. | Schuckit MA et al. | — | 2005 | → |
| GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. | Pierucci-Lagha A et al. | — | 2005 | → |
| Hangover frequency and risk for alcohol use disorders: evidence from a longitudinal high-risk study. | Piasecki TM et al. | — | 2005 | → |
| The development of alcohol use disorders. | Sher KJ et al. | — | 2005 | → |
| The level of response to alcohol in daughters of alcoholics and controls. | Eng MY et al. | — | 2005 | → |
| Biological and behavioral markers of alcohol sensitivity. | Fromme K et al. | — | 2004 | → |
| Differential response to alcohol in light and moderate female social drinkers. | Evans SM et al. | — | 2004 | → |
| Findings across subgroups regarding the level of response to alcohol as a risk factor for alcohol use disorders: a college population of women and Latinos. | Schuckit MA et al. | — | 2004 | → |
| Gender differences in risk factors and consequences for alcohol use and problems. | Nolen-Hoeksema S | — | 2004 | → |
| Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. | Heinz A et al. | — | 2004 | → |
| Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. | Radcliffe RA et al. | — | 2004 | → |
| Testing the level of response to alcohol: social information processing model of alcoholism risk--a 20-year prospective study. | Schuckit MA et al. | — | 2004 | → |
| Level of response to alcohol measured on the self-rating of the effects of alcohol questionnaire in a group of 40-year-old women. | Schuckit MA et al. | — | 2003 | → |
| Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. | Jeon YW et al. | — | 2003 | → |
| Response to alcohol in females with a paternal history of alcoholism. | Evans SM et al. | — | 2003 | → |
| Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. | Viken RJ et al. | — | 2003 | → |
| A comparison of two measures of low response to alcohol among heavy drinking male college students: implications for indicated prevention. | Daugherty R et al. | — | 2002 | → |
| A genome-wide search for genes that relate to a low level of response to alcohol. | Schuckit MA et al. | — | 2001 | → |
| An integrative approach for studying the etiology of alcoholism and other addictions. | Jacob T et al. | — | 2001 | → |
| Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. | Ehlers CL et al. | — | 2001 | → |
| P300 asymmetry in schizophrenia: a meta-analysis. | Jeon YW et al. | — | 2001 | → |
| Possible reasons why heavy drinking increases carbohydrate-deficient transferrin. | Sillanaukee P et al. | — | 2001 | → |
| Serotonergic dysfunction, negative mood states, and response to alcohol. | Heinz A et al. | — | 2001 | → |
| Visual p3 in female alcoholics. | Prabhu VR et al. | — | 2001 | → |
| Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders. Part 2. | Schuckit MA | — | 2000 | → |
| Genetics of the risk for alcoholism. | Schuckit MA | — | 2000 | → |
| Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. | Loh EW et al. | — | 2000 | → |
| A twin study of drinking and smoking onset and latencies from first use to regular use. | Stallings MC et al. | — | 1999 | → |
| Children of alcoholics exhibit attenuated cognitive impairment during an ethanol challenge. | Erblich J et al. | — | 1999 | → |
| Electroencephalographic responses to alcohol challenge in Native American Mission Indians. | Ehlers CL et al. | — | 1999 | → |
| Relationship between a GABAA alpha 6 Pro385Ser substitution and benzodiazepine sensitivity. | Iwata N et al. | — | 1999 | → |
| Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. | Schuckit MA et al. | — | 1999 | → |
| Alcohol dependence in adult children of alcoholics: longitudinal evidence of early risk. | Jennison KM et al. | — | 1998 | → |
| Effects of moderate alcohol consumption on the central nervous system. | Eckardt MJ et al. | — | 1998 | → |
| Acute reactions to alcohol. | Whitfield JB | — | 1997 | → |
| Smoking and intoxication after alcohol challenge in women and men: genetic influences. | Madden PA et al. | — | 1997 | → |
| Conference summary: Consensus Conference on Alcohol Dependence and the Role of Pharmacotherapy in its Treatment. | Chick J et al. | — | 1996 | → |
| Alcohol sensitivity and smoking history in men and women. | Madden PA et al. | — | 1995 | → |
| A Long-Term Study of Sons of Alcoholics. | Schuckit MA | — | 1995 | → |
| Is alcohol-related flushing a protective factor for alcoholism in Caucasians? | Slutske WS et al. | — | 1995 | → |
| Task persistence after alcohol consumption among children of alcoholics. | Baer JS et al. | — | 1995 | → |
| Variability of ethanol absorption and breath concentrations during a large-scale alcohol administration study. | Friel PN et al. | — | 1995 | → |
| Alcohol sensitivity and dependence. | Schuckit MA | — | 1994 | → |
| Divided attention task performance and subjective effects following alcohol and placebo: differences between women with and without a family history of alcoholism. | Lex BW et al. | — | 1994 | → |
| Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects. | Cowley DS et al. | — | 1994 | → |
| Low level of response to alcohol as a predictor of future alcoholism. | Schuckit MA | — | 1994 | → |
| Assessment of onset of panic disorder in relation to onset of agoraphobia. | Fava G | — | 1993 | → |