The role of GABA(A) receptors in the acute and chronic effects of ethanol.
paper
Cited
Public
Unavailable
- Authors
- Grobin, A C; Matthews, D B; Devaud, L L; Morrow, A L
- Year
- 1998
- Journal
- Psychopharmacology
- PMID
- 9768538
- DOI
- 10.1007/s002130050685
GABA(A) receptors are sensitive to ethanol in distinct brain regions and are clearly involved in the acute actions of ethanol, ethanol tolerance, ethanol dependence and ethanol self-administration. Data from a variety of perspectives such as molecular, cellular and behavioral analysis have elucidated the role of GABA(A) receptors in these processes. GABA(A) receptor activation mediates many of the behavioral effects of ethanol including motor incoordination, anxiolysis and sedation. The actions of ethanol at GABA(A) receptors are influenced by endogenous modulators such as the neuroactive steroids. Sensitization to these compounds influences ethanol dependence and withdrawal and may explain gender differences in the molecular effects of ethanol. Furthermore, GABA(A) receptors may also play a role in ethanol self-administration via the mesolimbic reward system. Ethanol tolerance and dependence may be explained, in part, by changes in the function of GABA(A) receptors. We have proposed that alterations in native GABA(A) receptor subunit assembly could alter the functional properties of these receptors. However, post-translational modifications or other post-synaptic mechanisms may also explain changes in GABA(A) receptor function. Genetic animal models of ethanol dependence have also identified GABA(A) receptor genes as likely mediators of the behavioral adaptations associated with ethanol dependence and withdrawal. A better understanding of the effects of ethanol at GABA(A) receptors has highlighted important potential mechanisms involved in the development of alcoholism.
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| Impact of sex: determination of alcohol neuroadaptation and reinforcement. | Wiren KM et al. | — | 2006 | → |
| Impact of the hormonal milieu on the neurobiology of alcohol dependence and withdrawal. | Devaud LL et al. | — | 2006 | → |
| Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. | Werner DF et al. | — | 2006 | → |
| Lifelong ethanol consumption and brain regional GABAA receptor subunit mRNA expression in alcohol-preferring rats. | Sarviharju M et al. | — | 2006 | → |
| Low dose acute alcohol effects on GABA A receptor subtypes. | Wallner M et al. | — | 2006 | → |
| Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. | Cai YQ et al. | — | 2006 | → |
| Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde. | Arizzi-LaFrance MN et al. | — | 2006 | → |
| Neurorobiology and evidence-based biological treatments for substance abuse disorders. | Ivanov IS et al. | — | 2006 | → |
| Neurosteroids, GABAA receptors, and ethanol dependence. | Follesa P et al. | — | 2006 | → |
| Participation of alpha-melanocyte stimulating hormone in ethanol-induced anxiolysis and withdrawal anxiety in rats. | Kokare DM et al. | — | 2006 | → |
| Pharmacotherapy for alcohol dependence: anticraving medications for relapse prevention. | Jung YC et al. | — | 2006 | → |
| Progesterone withdrawal effects in the open field test can be predicted by elevated plus maze performance. | Löfgren M et al. | — | 2006 | → |
| Queer currents, steady rhythms, and drunken da neurons. Focus on "hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice". | Lupica CR et al. | — | 2006 | → |
| Role of brain neuroactive steroids in the functional interplay between the GABA(A) and the NPY-Y1 receptor mediated signals in the amygdala. | Eva C et al. | — | 2006 | → |
| Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol. | Pierucci-Lagha A et al. | — | 2006 | → |
| Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. | Padmanabhapillai A et al. | — | 2006 | → |
| The genetics of alcohol dependence. | Dick DM et al. | — | 2006 | → |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | — | 2006 | → |
| Alcohol withdrawal kindling: is there a role for anticonvulsants? | Modesto-Lowe V et al. | — | 2005 | → |
| Alternative splicing and promoter use in the human GABRA2 gene. | Tian H et al. | — | 2005 | → |
| Development of acute tolerance during steady-state arterial alcohol concentrations: a study of auditory event-related potentials in rats. | Morzorati SL et al. | — | 2005 | → |
| Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats. | Alele PE et al. | — | 2005 | → |
| Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons. | Wu PH et al. | — | 2005 | → |
| Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. | Gorin RE et al. | — | 2005 | → |
| Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats. | Martin-Garcia E et al. | — | 2005 | → |
| Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats. | Saba L et al. | — | 2005 | → |
| GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study. | Lingford-Hughes AR et al. | — | 2005 | → |
| GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. | Pierucci-Lagha A et al. | — | 2005 | → |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | — | 2005 | → |
| Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats. | Martín-García E et al. | — | 2005 | → |
| Laboratory models of alcoholism: treatment target identification and insight into mechanisms. | Lovinger DM et al. | — | 2005 | → |
| Magnetic resonance spectroscopic studies of alcoholism: from heavy drinking to alcohol dependence and back again. | Mason G et al. | — | 2005 | → |
| Malingering and forensic psychiatry. | Feuerstein S et al. | — | 2005 | → |
| Management of delirium tremens. | DeBellis R et al. | — | 2005 | → |
| Mice lacking the major adult GABAA receptor subtype have normal number of synapses, but retain juvenile IPSC kinetics until adulthood. | Bosman LW et al. | — | 2005 | → |
| Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands. | Knapp DJ et al. | — | 2005 | → |
| Neuroactive steroids and ethanol. | Purdy RH et al. | — | 2005 | → |
| Neuroimaging of rodent and primate models of alcoholism: initial reports from the integrative neuroscience initiative on alcoholism. | Sullivan EV et al. | — | 2005 | → |
| Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice. | Ford MM et al. | — | 2005 | → |
| New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence. | Kiefer F et al. | — | 2005 | → |
| No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. | Dick DM et al. | — | 2005 | → |
| Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? | Ford MM et al. | — | 2005 | → |
| Acute ethanol withdrawal (hangover) and social behavior in adolescent and adult male and female Sprague-Dawley rats. | Varlinskaya EI et al. | — | 2004 | → |
| Alcohol intoxication increases allopregnanolone levels in male adolescent humans. | Torres JM et al. | — | 2004 | → |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | — | 2004 | → |
| Allelic and haplotypic association of GABRA2 with alcohol dependence. | Covault J et al. | — | 2004 | → |
| A role for GABA mechanisms in the motivational effects of alcohol. | Koob GF | — | 2004 | → |
| Association of GABRG3 with alcohol dependence. | Dick DM et al. | — | 2004 | → |
| Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. | Sanna E et al. | — | 2004 | → |
| Comparison of deramciclane to benzodiazepine agonists in behavioural activity of mice and in alcohol drinking of alcohol-preferring rats. | Ingman K et al. | — | 2004 | → |
| Differential effects of chronic ethanol administration and withdrawal on gamma-aminobutyric acid type A and NMDA receptor subunit proteins in male and female rat brain. | Devaud LL et al. | — | 2004 | → |
| Ethanol effects on cell signaling mechanisms. | Morrow AL et al. | — | 2004 | → |
| Ethanol palatability and consumption by high ethanol-drinking rats: manipulation of the opioid system with naltrexone. | Coonfield DL et al. | — | 2004 | → |
| Ethanol potentiation of GABAergic synaptic transmission may be self-limiting: role of presynaptic GABA(B) receptors. | Ariwodola OJ et al. | — | 2004 | → |
| Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms. | Kumar S et al. | — | 2004 | → |
| Ethanol withdrawal-induced up-regulation of the alpha2 subunit of the GABAA receptor and its prevention by diazepam or gamma-hydroxybutyric acid. | Follesa P et al. | — | 2004 | → |
| GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice. | de Almeida RM et al. | — | 2004 | → |
| Genes associated with addiction: alcoholism, opiate, and cocaine addiction. | Kreek MJ et al. | — | 2004 | → |
| Genetic manipulations of GABAA receptor in mice make inhibition exciting. | Vicini S et al. | — | 2004 | → |
| Increased GABA release in the central amygdala of ethanol-dependent rats. | Roberto M et al. | — | 2004 | → |
| Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons. | Mostallino MC et al. | — | 2004 | → |
| Interaction of chronic ethanol exposure and finasteride: sex and strain differences. | Finn DA et al. | — | 2004 | → |
| Pharmacotherapy of alcohol dependence: a review of the clinical data. | Mann K | — | 2004 | → |
| Polysomnographic comparison between patients with primary alcohol dependency during subacute withdrawal and patients with a major depression. | Gann H et al. | — | 2004 | → |
| Potential pleiotropic effects of Mpdz on vulnerability to seizures. | Fehr C et al. | — | 2004 | → |
| Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. | Finn DA et al. | — | 2004 | → |
| The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100Q) sNP rats. | Sanna A et al. | — | 2004 | → |
| [The importance of sleep for healthy alcohol consumers and alcohol dependent patients]. | Gann H et al. | — | 2004 | → |
| The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. | Kamarajan C et al. | — | 2004 | → |
| The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. | Finn DA et al. | — | 2004 | → |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | — | 2004 | → |
| The use of acute ethanol administration as a tool to investigate multiple memory systems. | Matthews DB et al. | — | 2004 | → |
| Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats. | Cagetti E et al. | — | 2004 | → |
| Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. | Edenberg HJ et al. | — | 2004 | → |
| AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit. | Carr LG et al. | — | 2003 | → |
| Acute alcohol administration improves skilled reaching success in intact but not 6-OHDA dopamine depleted rats: a subsystems analysis of the motoric and anxiolytic effects of alcohol. | Metz GA et al. | — | 2003 | → |
| Alcohol intoxication increases allopregnanolone levels in female adolescent humans. | Torres JM et al. | — | 2003 | → |
| Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects. | Wang GJ et al. | — | 2003 | → |
| alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo. | Täuber M et al. | — | 2003 | → |
| Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. | Song J et al. | — | 2003 | → |
| Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. | Ericson M et al. | — | 2003 | → |
| Candidate genes for alcohol dependence: a review of genetic evidence from human studies. | Dick DM et al. | — | 2003 | → |
| Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. | Sanna E et al. | — | 2003 | → |
| Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP). | Sanna A et al. | — | 2003 | → |
| Chronic ethanol consumption enhances internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex. | Kumar S et al. | — | 2003 | → |
| Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats. | Nie H et al. | — | 2003 | → |
| Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. | Kralic JE et al. | — | 2003 | → |
| Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity. | Tokunaga S et al. | — | 2003 | → |
| Ethanol-induced suppression of LTP can be attenuated with an angiotensin IV analog. | Wright JW et al. | — | 2003 | → |
| Ethanol modulation of excitatory and inhibitory synaptic transmission in rat and monkey dentate granule neurons. | Ariwodola OJ et al. | — | 2003 | → |
| Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. | Fehr C et al. | — | 2003 | → |
| Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications. | Fritschy JM et al. | — | 2003 | → |
| Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells. | Follesa P et al. | — | 2003 | → |
| Impairments in spatial learning and memory: ethanol, allopregnanolone, and the hippocampus. | Silvers JM et al. | — | 2003 | → |
| Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype. | Congeddu E et al. | — | 2003 | → |
| Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators. | Biggio G et al. | — | 2003 | → |
| Neurosteroids, GABAA receptors, and escalated aggressive behavior. | Miczek KA et al. | — | 2003 | → |
| New neuronal networks involved in ethanol reinforcement. | Kiianmaa K et al. | — | 2003 | → |
| Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice. | Kaminski RM et al. | — | 2003 | → |
| The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. | Davies M | — | 2003 | → |
| Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. | Varlinskaya EI et al. | — | 2002 | → |
| Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task. | Matthews DB et al. | — | 2002 | → |
| Alcohol unmasks simian immunodeficiency virus-induced cognitive impairments in rhesus monkeys. | Winsauer PJ et al. | — | 2002 | → |
| Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. | Kumar S et al. | — | 2002 | → |
| Differential taurine responsiveness to ethanol in high- and low-alcohol sensitive rats: a brain microdialysis study. | Quertemont E et al. | — | 2002 | → |
| Drug interactions at GABA(A) receptors. | Korpi ER et al. | — | 2002 | → |
| GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. | Chester JA et al. | — | 2002 | → |
| GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid. | Barbaccia ML et al. | — | 2002 | → |
| GABAergic neurosteroid modulation of ethanol actions. | Khisti RT et al. | — | 2002 | → |
| Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. | Kralic JE et al. | — | 2002 | → |
| Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol. | Barbosa AD et al. | — | 2002 | → |
| Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride. | Dazzi L et al. | — | 2002 | → |
| Reinforcing effects of the neurosteroid allopregnanolone in rats. | Sinnott RS et al. | — | 2002 | → |
| The effects of vigabatrin on electrophysiology and visual fields in epileptics: a controlled study with a discussion of possible mechanisms. | Comaish IF et al. | — | 2002 | → |
| A benzodiazepine mood effect scale: reliability and validity determined for alcohol-dependent subjects and adults with a parental history of alcoholism. | Ciraulo DA et al. | — | 2001 | → |
| Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol. | Hodge CW et al. | — | 2001 | → |
| Chronic benzodiazepine administration facilitates the subsequent development of ethanol dependence. | Martijena ID et al. | — | 2001 | → |
| Chronic ethanol consumption differentially alters GABA(A) receptor alpha1 and alpha4 subunit peptide expression and GABA(A) receptor-mediated 36 Cl(-) uptake in mesocorticolimbic regions of rat brain. | Papadeas S et al. | — | 2001 | → |
| Ethanol and neurosteroid interactions in the brain. | Morrow AL et al. | — | 2001 | → |
| Ethanol dependence has limited effects on GABA or glutamate transporters in rat brain. | Devaud LL | — | 2001 | → |
| GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. | Mihalek RM et al. | — | 2001 | → |
| Importance of magnesium ions in development of tolerance to ethanol: studies on cultured cerebral vascular smooth muscle cells, type-2 astrocytes and intact rat brain. | Li W et al. | — | 2001 | → |
| Neurosteroids and behavior. | Engel SR et al. | — | 2001 | → |
| Role of glutamatergic and GABAergic systems in alcoholism. | Davis KM et al. | — | 2001 | → |
| The R100Q mutation of the GABA(A) alpha(6) receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line. | Saba L et al. | — | 2001 | → |
| The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. | Morrow AL et al. | — | 2001 | → |
| Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. | Hood HM et al. | — | 2000 | → |
| Anatomic and molecular principles of psychopharmacology. A primer for psychiatrists. | Heckers S et al. | — | 2000 | → |
| Applications of transgenic and knockout mice in alcohol research. | Bowers BJ | — | 2000 | → |
| Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population. | Loh EW et al. | — | 2000 | → |
| Chronic ethanol consumption alters recovery of spontaneously active medial septal/diagonal band of broca neurons from GABA-microiontophoresis. | Matthews DB et al. | — | 2000 | → |
| Chronic ethanol treatment and GABA(A) receptor α6 subunit gene expression: a study using α6 subunit-deficient mice. | Vekovischeva OY et al. | — | 2000 | → |
| Chronic exposure to ethanol alters GABA(A) receptor-mediated responses of layer II pyramidal cells in adult rat piriform cortex. | Signore AP et al. | — | 2000 | → |
| Different sensitivity to ethanol in alcohol-preferring sP and -nonpreferring sNP rats. | Colombo G et al. | — | 2000 | → |
| Effects of ethanol on hippocampal place-cell and interneuron activity. | White AM et al. | — | 2000 | → |
| Ethanol, memory, and hippocampal function: a review of recent findings. | White AM et al. | — | 2000 | → |
| Gene expression of receptors and enzymes involved in GABAergic and glutamatergic neurotransmission in the CNS of rats behaviourally dependent on ethanol. | Eravci M et al. | — | 2000 | → |
| Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis. | Jalan R et al. | — | 2000 | → |
| In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat. | Prendergast MA et al. | — | 2000 | → |
| Levels of gamma-aminobutyric acid-benzodiazepine receptors in abstinent, alcohol-dependent women: preliminary findings from an 123I-iomazenil single photon emission tomography study. | Lingford-Hughes AR et al. | — | 2000 | → |
| Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. | VanDoren MJ et al. | — | 2000 | → |
| Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65. | Stork O et al. | — | 2000 | → |
| P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking. | Kampov-Polevoy AB et al. | — | 2000 | → |
| Regional variations in the effects of chronic ethanol administration on GABA(A) receptor expression: potential mechanisms. | Grobin AC et al. | — | 2000 | → |
| Acute effects of ethanol on GABAA and glycine receptor function. | Mihic SJ | — | 1999 | → |
| Ethanol and protein kinase C. | Stubbs CD et al. | — | 1999 | → |
| Ethanol directly excites dopaminergic ventral tegmental area reward neurons. | Brodie MS et al. | — | 1999 | → |
| Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats. | Barbaccia ML et al. | — | 1999 | → |
| Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. | Chistina Grobin A et al. | — | 1999 | → |
| Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures. | Grant KA | — | 1999 | → |
| Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one in male and female rats. | Janis GC et al. | — | 1998 | → |